scholarly journals Preparation of new lipiodol-emulsion containing water soluble anticancer agent by membrane emulsification technique.

1993 ◽  
Vol 8 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Shushi Higashi ◽  
Masataka Shimizu ◽  
Toshiaki Setoguchi
Keyword(s):  
Anticancer Agent ◽  
Water Soluble ◽  
Membrane Emulsification ◽  
Lipiodol Emulsion

scholarly journals Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment

RSC Advances ◽  
2020 ◽  
Vol 10 (42) ◽  
pp. 25290-25304
Author(s):  
Nazanin Bagheri ◽  
Moslem Mansour Lakouraj ◽  
Seyed Reza Nabavi ◽  
Hamed Tashakkorian ◽  
Mojtaba Mohseni
Keyword(s):  
Cancer Therapy ◽  
Polyacrylic Acid ◽  
Anticancer Agent ◽  
Water Soluble ◽  
Acid Copolymer ◽  
Water Soluble Copolymer

In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced.

A Novel pH-Sensitive Microsphere Composed of CM-Chitosan and Alginate for Sulforaphane Delivery

2011 ◽  
Vol 687 ◽  
pp. 539-547 ◽  
Author(s):  
Hui Wang ◽  
Hao Liang ◽  
Qi Peng Yuan ◽  
Tian Xin Wang
Keyword(s):  
Sodium Sulfate ◽  
Anticancer Agent ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Ph Values ◽  
Swelling Studies ◽  
The Stability ◽  
Carboxymethylated Chitosan

Sulforaphane (SF) has been proved to be an effective anticancer agent according to its experiments bothin vitroandin vivo. To date, there is few reported method to deliver SF for increasing its bioactivity and stability. In this study, a novel pH-sensitive microsphere composed of water-soluble carboxymethylated chitosan (CMCS) and alginate mixed with sodium sulfate was developed for SF delivery. Swelling studies and release characteristics under different pH values of microspheres were investigated. Then, the release of SF from test microspheres was studied in simulated gastric and segmented intestinal media. It has been found that the SF cumulated release in 5h was increased from 55.89% to 76.73% when the microspheres mixed with sodium sulfate. In addition, the stability of SF embedded in CMCS/alginate microspheres was also significantly improved. Under pH 7.4, free SF had a severe degradation of approximate 100% within 210 min, whereas the change of the SF in microspheres was only a decrease of about 10%. The results suggested that the microspheres of CMCS and alginate could be a suitable pH-sensitive carrier to increase the stability of SF in the segmented intestine.

Abstract C166: Preclinical studies of Ureidomustin, a potent water-soluble anticancer agent.

2011 ◽  
Author(s):  
Tsann-Long Su ◽  
Yi-Ren Chen ◽  
Rajesh Kakadiya ◽  
Pei-Wen Hsiao ◽  
Te-Chang Lee ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Water Soluble ◽  
Preclinical Studies

A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

MedChemComm ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 1515-1519 ◽  
Author(s):  
Rie Wakabayashi ◽  
Ryutaro Ishiyama ◽  
Noriho Kamiya ◽  
Masahiro Goto
Keyword(s):  
Anticancer Agent ◽  
Water Soluble ◽  
Poorly Water Soluble

In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT).

Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent

2007 ◽  
Vol 342-343 ◽  
pp. 469-472 ◽  
Author(s):  
Dong Gon Kim ◽  
Min Ja Jang ◽  
Chang Yong Choi ◽  
Tae Hyeong Kim ◽  
Mi Kyeong Jang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Anticancer Agent ◽  
Drug Carrier ◽  
Chitosan Nanoparticles ◽  
Water Soluble ◽  
Molecular Water ◽  
Low Molecular Weight ◽  
Receptor Mediated Endocytosis ◽  
Chitosan Nanoparticle ◽  
High Antitumor Activity

In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid (NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore, LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated endocytosis.

scholarly journals High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Riki Kadokawa ◽  
Tetsuo Fujie ◽  
Gyanendra Sharma ◽  
Kojiro Ishibashi ◽  
Kazuaki Ninomiya ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Anticancer Agent ◽  
Hepatic Arterial Infusion ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
High Loading ◽  
High Concentration ◽  
High Solubility ◽  
Arterial Infusion ◽  
Poorly Water Soluble

AbstractTrimethylglycine (TMG) is a cheap, natural, and highly biocompatible compound. Therefore, it has been used in the fields of food and life sciences, but the application of solid TMG is limited to utilisation as an “additive”. In the present study, we focussed on the high solubility of TMG in water, derived from the aprotic zwitterionic structure, and proposed TMG as the chemical accounting for a major portion of the aqueous solution (e.g., 50 wt%). High loading of TMG shifted the properties of water and enabled the dissolution of poorly water-soluble cisplatin, an anticancer agent, at high concentration (solubility of cisplatin: 0.15 wt% in water vs 1.7 wt% in TMG aqueous solution). For hepatic arterial infusion, this can reduce the amount of cisplatin administered from 40 to 4 mL. It enables simple injection using a syringe, without the need for catheters and automatic pumps, leading to critical alleviation of the risk to patients. Furthermore, we produced a dry powder from a cisplatin-containing TMG aqueous solution via freeze-drying. Powders can be conveniently stored and transported. Furthermore, cisplatin is often used as a mixture with other drugs, and cisplatin aqueous solutions are not preferred as they dilute the other drugs.

Sign in / Sign up

Export Citation Format

Share Document