scholarly journals Drug delivery system. Oral administration of BRM (OK-432 medium chain triglyceride emulsion) and inhibition of hepatic metastasis.

1989 ◽  
Vol 4 (4) ◽  
pp. 276-280
Author(s):  
Masao Fujimaki ◽  
Tokuzo Kasagi ◽  
Kenji Tazawa ◽  
Masatoshi Maeda ◽  
Takashi Honda
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hepatic Metastasis ◽  
Medium Chain Triglyceride ◽  
Medium Chain

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

scholarly journals Drug delivery system on the base of phospholipid nanoparticles for rifampicin

2013 ◽  
Vol 59 (5) ◽  
pp. 585-590 ◽  
Author(s):  
M.A. Sanzhakov ◽  
V.N. Prozorovskyi ◽  
O.M. Ipatova ◽  
E.G. Tikhonova ◽  
N.V. Medvedeva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sodium Oleate ◽  
Fold Increase ◽  
Phospholipid Nanoparticles ◽  
Antituberculous Drug

Low bioavailability of rifampicin, one of the main antituberculous drug, stimulates searches of its new optimized formulations. The present study has showen possibility of rifampicin embedding into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase of the percent of rifampicin incorporation. After oral administration to rats, the maximal drug observed in plasma one hour after was 0.5 and 4.2 mkg/ml for free rifampicin for rifampicin in phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than two hours of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests prospectivity of its pharmaceutical elaboration.

scholarly journals Enhanced Dissolution and Oral Bioavailability of Cyclosporine A: Microspheres Based on αβ-Cyclodextrins Polymers

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 285 ◽  
Author(s):  
Malika Lahiani-Skiba ◽  
Francois Hallouard ◽  
Frederic Bounoure ◽  
Nicolas Milon ◽  
Youness Karrout ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Secondary Structure ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cyclosporine A ◽  
Polymer Mixture ◽  
Pharmacokinetic Parameters

Cyclosporine (CsA) has a selective property of suppressing various T-lymphocyte functions. This is of utmost importance in preventing allograft rejection by several organ transplantations, as well as in the treatment of systemic and local autoimmune disorders. However, the poor water solubility of CsA can be a major hurdle for its absorption into the blood stream, which leads to low bioavailability and thus less efficacy. The aim of this study was to prepare, characterize, and evaluate in vitro as well as in vivo, the potential of the innovative CsA drug delivery system. The latter contains CsA in spherical amorphous solid dispersion (SASD) which is embedded in an original α-cyclodextrin and β-cyclodextrin polymer mixture (Poly-αβ-CD) as a multifunctional amorphous carrier. The new developed SASD formulation showed that CsA was molecularly dispersed in αβ-cyclodextrins in an amorphous form, as was confirmed by physicochemical characterization studies. Interestingly, the peptide secondary structure, and thus, the drug activity was not impacted by the preparation of SASD as was shown by circular dichroism. Furthermore, the in vitro CsA release profile kinetics was almost identical to the commercially available product Neoral®. This study presents the first in vivo proof-of-concept for a novel drug delivery system based on Poly-αβ-CD containing CsA, with SASD allowing for increased bioavailibility. The pharmacokinetic parameters of cyclosporine A from the spherical spray-dried dispersion formulation was demonstrated in a “rat” animal model. For comparison, the commercially available Neoral® was studied. Importantly, the pharmacokinetic parameters were improved by extending Tmax from 2 to 3 h after the oral administration in rats, and eventually preventing the enterohepatic circulation. All these results clearly demonstrate the improved pharmacokinetic parameters and enhanced bioavailability of CsA in the new developed drug delivery system. These data demonstrated the superiority of the newly developed Poly-αβ-CD formulation for oral administration of the poorly soluble CsA in vivo without altering its secondary structure. Poly-αβ-CD can be a very useful tool for the oral administration of poorly water-soluble drugs.

Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route

2015 ◽  
Vol 21 (29) ◽  
pp. 4355-4365 ◽  
Author(s):  
Ang Chen ◽  
Ye Shi ◽  
Zhiqiang Yan ◽  
Hongxun Hao ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Administration Route
Sign in / Sign up

Export Citation Format

Share Document