scholarly journals Nose-to-brain delivery of drug/nucleic acid drug targeted for central nerve system: 12th Young Scientist Award, Japan Society of DDS

2020 ◽  
Vol 35 (5) ◽  
pp. 434-441
Author(s):  
Takanori Kanazawa
Keyword(s):  
Nucleic Acid ◽  
Young Scientist ◽  
Brain Delivery ◽  
Japan Society ◽  
Central Nerve System ◽  
Nerve System ◽  
Nucleic Acid Drug

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

Aromatherapy and the Central Nerve System (CNS): Therapeutic Mechanism and its Associated Genes

2013 ◽  
Vol 14 (8) ◽  
pp. 872-879 ◽  
Author(s):  
Xiao Lv ◽  
Zhu Liu ◽  
Huan Zhang ◽  
Chi Tzeng
Keyword(s):  
Central Nerve System ◽  
Therapeutic Mechanism ◽  
Nerve System

scholarly journals Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery

2021 ◽  
Vol 22 (3) ◽  
pp. 1203
Author(s):  
Lu Qian ◽  
Julia TCW
Keyword(s):  
Drug Discovery ◽  
Disease Modeling ◽  
Three Dimensional ◽  
Structural Complexity ◽  
Induced Pluripotent Stem Cell ◽  
Cell Types ◽  
Central Nerve System ◽  
Human Ipscs ◽  
Nerve System

A high-throughput drug screen identifies potentially promising therapeutics for clinical trials. However, limitations that persist in current disease modeling with limited physiological relevancy of human patients skew drug responses, hamper translation of clinical efficacy, and contribute to high clinical attritions. The emergence of induced pluripotent stem cell (iPSC) technology revolutionizes the paradigm of drug discovery. In particular, iPSC-based three-dimensional (3D) tissue engineering that appears as a promising vehicle of in vitro disease modeling provides more sophisticated tissue architectures and micro-environmental cues than a traditional two-dimensional (2D) culture. Here we discuss 3D based organoids/spheroids that construct the advanced modeling with evolved structural complexity, which propels drug discovery by exhibiting more human specific and diverse pathologies that are not perceived in 2D or animal models. We will then focus on various central nerve system (CNS) disease modeling using human iPSCs, leading to uncovering disease pathogenesis that guides the development of therapeutic strategies. Finally, we will address new opportunities of iPSC-assisted drug discovery with multi-disciplinary approaches from bioengineering to Omics technology. Despite technological challenges, iPSC-derived cytoarchitectures through interactions of diverse cell types mimic patients’ CNS and serve as a platform for therapeutic development and personalized precision medicine.

scholarly journals Comment on: Dietary yeast reduce inflammation in central nerve system via microflora

2015 ◽  
Vol 2 (11) ◽  
pp. 1038-1039
Author(s):  
Carlo Perricone ◽  
Maurizio Rinaldi ◽  
Yehuda Shoenfeld
Keyword(s):  
Central Nerve System ◽  
Nerve System

scholarly journals Muscular Movements in Man, and their Evolution in the Infant: a Study of Movement in Man, and its Evolution, together with Inferences as to the Properties of Nerve-Centres and their Modes of Action in expressing Thought

1889 ◽  
Vol 35 (149) ◽  
pp. 23-44 ◽  
Author(s):  
Francis Warner
Keyword(s):  
Brain Area ◽  
Muscular Contraction ◽  
The Body ◽  
Brain Areas ◽  
Modes Of Action ◽  
Central Nerve System ◽  
Nerve System ◽  
The Brain ◽  
Compound Series ◽  
Stimulation Of

(1) Movement in mau has long been a subject of profitable study. Visible movement in the body is produced by muscular contraction following upon stimulation of the muscles by efferent currents passing from the central nerve-system. Modern physiological experiments have demonstrated that when a special brain-area discharges nerve-currents, these are followed by certain visible movements or contraction of certain muscles corresponding. So exact are such reactions, as obtained by experiment upon the brain-areas, that movements similar to those produced by experimental excitation of a certain brain-area may be taken as evidence of action in that area, or as commencing in discharge from that area (see Reinforcement of Movements, 35; Compound Series of Movements, 34).

scholarly journals Menurunkan Skala Nyeri Bayi Prematur melalui Facilitated Tucking disertai ‘Hadir-Berbicara’ sebagai Upaya Penerapan Teori Comfort Kolcaba

2017 ◽  
Vol 5 (2) ◽  
pp. 83
Author(s):  
Nopi Nur Khasanah ◽  
Yeni Rustina
Keyword(s):  
Premature Infants ◽  
Early Life ◽  
Nursing Intervention ◽  
Comfort Level ◽  
High Risk Infant ◽  
Developmental Care ◽  
Central Nerve System ◽  
Nerve System ◽  
Neonatal Ward

<em>Premature infants had been experience of pain in neonatal ward that occur each day during treatment. Nurse need to do an intervention for reduce the scale of pain on premature infants. Pain management have to do at birth because of the repeated painful procedures in early life can affect the development of central nerve system permanently. The objective of this study was to describe the application of Kolcaba Comfort’s theory through facilitated tucking accompanied with ‘being with-talking to’ techniques in premature’s infant at high risk infant care. The method that used was case study by applying the four contexts of comfort’s experience associated with the three types of comfort based on Kolcaba Comfort’s theory in providing nursing care on five premature infants who have some painful procedures. The nursing intervention through facilitated tucking accompanied by ‘being with-talking to’ based on the principles of Kolcaba Comfort’s theory gave a positive result against premature infants’s comfort level. Four from five premature infants are in the level of transcendence which is a type of supreme comfort after the ease and relief. Kolcaba Comfort’s theory can be applied within the scope of neonatal care due in accordance with the developmental care of the infants and could reduce the scale of pain.</em>

Sign in / Sign up

Export Citation Format

Share Document