scholarly journals Improvement of transmucosal absorption of drugs in drug delivery system (DDS) 2. Improvement of intestinal drug absorption based on structural changes of tight junction and functional changes of P-glycoprotein

2005 ◽  
Vol 20 (4) ◽  
pp. 416-423
Author(s):  
Mikio Tomita ◽  
Masahiro Hayashi
Keyword(s):  
Drug Delivery ◽  
Tight Junction ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Absorption ◽  
Structural Changes ◽  
Functional Changes ◽  
Intestinal Drug Absorption ◽  
P Glycoprotein

Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

2016 ◽  
Vol 4 (36) ◽  
pp. 6043-6051 ◽  
Author(s):  
Junling Wang ◽  
Ran Wang ◽  
Fangrong Zhang ◽  
Yajun Yin ◽  
Leixia Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Carbon Nanohorns ◽  
P Glycoprotein ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A targeted drug delivery system based on carbon nanohorns for targeting P-glycoprotein and delivering etoposide into cells to overcome multidrug resistance.

scholarly journals A REVIEW ON NASAL DRUG DELIVERY SYSTEM AND ITS CONTRIBUTION IN THERAPEUTIC MANAGEMENT

2019 ◽  
Vol 12 (1) ◽  
pp. 40
Author(s):  
Sulaiman Alnasser
Keyword(s):  
Drug Delivery ◽  
Nasal Cavity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Absorption ◽  
Delivery Systems ◽  
Nasal Delivery ◽  
Present Review ◽  
Drug Formulations ◽  
Nasal Drug Delivery

Nasal drug delivery has received a great deal of attention as a convenient, reliable, and promising method for the systemic administration of drugs. It is especially for those molecules which are ineffective orally and only effective if administered by injection. The nasal route of drug delivery has advantages over the other alternative systems of non-invasive drug administration. The present review describes nasal delivery systems in recognizing to its potential and limits. The present review is an attempt to provide some information concerning nasal drug delivery system such as limitations, advantages, mechanism of drug absorption, anatomy of nasal cavity, factors affecting of nasal drug delivery, strategies to enhance nasal absorption, strategies to extend duration of drug formulations within the nasal cavity, leading to improved nasal drug absorption, novel drug formulations, sorts of nasal drug delivery system with uses of nasal drug delivery in various diseases, and recent advancement of nasal delivery systems.

Recent Developments and Potential of Mucoadhesive Buccal Drug Delivery System for Oro-mucosal Disorders

2020 ◽  
Vol 2 (1) ◽  
pp. 12-28
Author(s):  
Deepak Sharma ◽  
Rajeev Garg
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Absorption ◽  
Target Site ◽  
Limited Area ◽  
Epithelial Surface ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Recent Developments

Background: The drug delivery across buccal mucosa is a very interesting option for the treatment of various oro-mucosal disorders such as aphthous stomatitis, periodontitis, gingivitis, toothache, periodontitis, and sjorgensen syndrome. But it is quite difficult because of target site movements, limited area for drug absorption, drinking of fluids, intake of food and saliva flow at regular intervals, contributing to poor retention and sub-therapeutic level of drug at the target site. Due to this, the mucoadhesive buccal drug delivery system has gained a great deal of attention among the various scientists and researchers over the last two decades. Methods: Mucoadhesion is a process of attachment between the natural or synthetic macromolecule and mucosal epithelial surface with the aid of interfacial attractive forces. The process of mucoadhesion has been extensively encouraged by the utilization of mucoadhesive polymers within the formulation that on contact with salivary fluid swells and adheres to buccal epithelium membrane, thus prolonging the drug release, retention time and improving therapeutic performance in case of oral diseases. The present review tries to cover the basic anatomy and structure of oral mucosa, pathways of drug absorption, the theory of mucoadhesion, mechanisms involved in mucoadhesion and various factors affecting mucoadhesion. Results: It highlights the properties of mucoadhesive polymers in drug delivery along with various dosage forms such as mucoadhesive tablets, films, patches, gels, and pastes. Furthermore, it also sheds light on the recent developments made in the field of mucoadhesive buccal drug delivery system that reflects the potential of this system for the effective treatment of oro-mucosal disorders. Conclusion: It can be concluded that the mucoadhesive buccal drug delivery system has great potential in the near future for treating oro-mucosal disorders.

scholarly journals A REVIEW ON NASAL DRUG DELIVERY SYSTEM AND ITS CONTRIBUTION IN THERAPEUTIC MANAGEMENT

2019 ◽  
Vol 12 (1) ◽  
pp. 40 ◽  
Author(s):  
Sulaiman Alnasser
Keyword(s):  
Drug Delivery ◽  
Nasal Cavity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Absorption ◽  
Delivery Systems ◽  
Nasal Delivery ◽  
Present Review ◽  
Drug Formulations ◽  
Nasal Drug Delivery

Nasal drug delivery has received a great deal of attention as a convenient, reliable, and promising method for the systemic administration of drugs. It is especially for those molecules which are ineffective orally and only effective if administered by injection. The nasal route of drug delivery has advantages over the other alternative systems of non-invasive drug administration. The present review describes nasal delivery systems in recognizing to its potential and limits. The present review is an attempt to provide some information concerning nasal drug delivery system such as limitations, advantages, mechanism of drug absorption, anatomy of nasal cavity, factors affecting of nasal drug delivery, strategies to enhance nasal absorption, strategies to extend duration of drug formulations within the nasal cavity, leading to improved nasal drug absorption, novel drug formulations, sorts of nasal drug delivery system with uses of nasal drug delivery in various diseases, and recent advancement of nasal delivery systems.

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