Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties

2001 ◽  
Vol 6 (1) ◽  
pp. d526 ◽  
Author(s):  
Debi, K. Swertfeger
Keyword(s):  
Cell Signaling ◽  
Apolipoprotein E ◽  
Transport Protein ◽  
Lipid Transport ◽  
Cholesterol Transport

Apolipoprotein E gene and Alzheimer's disease: is tau the link?

2001 ◽  
Vol 67 ◽  
pp. 111-120 ◽  
Author(s):  
Simon Lovestone ◽  
Brian Anderton ◽  
Joanna Betts ◽  
Rejith Dayanandan ◽  
Graham Gibb ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Significant Advance ◽  
Cholesterol Transport ◽  
Vascular Risk ◽  
Polymorphic Variation ◽  
Gene Encoding ◽  
Single Mechanism ◽  
Apolipoprotein E Gene

The finding that APOE (the gene encoding apolipoprotein E) polymorphic variation was associated with an altered risk of developing Alzheimer's disease (AD) was a significant advance and immediately prompted a search for the mechanisms responsible for this alteration. Some 6 years later, a number of different hypotheses remain that might account for this influence on pathogenesis with no single mechanism being unequivocally accepted. The different approaches to understanding these mechanisms can be broadly categorized as: those suggesting a remote effect, such as different rates of vascular risk factors in those with the different APOE alleles; those proposing altered neuronal vulnerability, perhaps due to apolipoprotein E (ApoE)-isoform-specific differences in local cholesterol transport; and those hypotheses postulating an ApoE interaction with the two key lesions of AD, plaques and tangles. In this chapter we will review the evidence for and against an interaction between ApoE and the neuronal cytoskeleton, in particular with the microtubule-associated protein tau.

scholarly journals Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

2020 ◽  
Vol 219 (5) ◽  
Author(s):  
PeiQi Li ◽  
Joshua Aaron Lees ◽  
C. Patrick Lusk ◽  
Karin M. Reinisch
Keyword(s):  
Fatty Acid ◽  
Single Particle ◽  
Transport Protein ◽  
Lipid Transport ◽  
Hydrophobic Residues ◽  
Terminal Fragment ◽  
Lipid Fatty Acid ◽  
Related Proteins ◽  
Long Channel

A single particle cryo-EM reconstruction of an ∼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an ∼160-Å long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like the autophagy protein ATG2, can act as bridges between organelle membranes to allow bulk lipid flow between organelles.

Impact of Aging on Cholesterol Transport Protein Expression and Steroidogenesis in Rat Testicular Leydig Cells

2008 ◽  
Vol 2 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Zhihong Sun ◽  
Wen-Jun Shen ◽  
Susan-Leers Sucheta ◽  
Salman Azhar
Keyword(s):  
Protein Expression ◽  
Leydig Cells ◽  
Transport Protein ◽  
Cholesterol Transport
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