Parathyroid hormone-related peptide and primary hyperparathyroidism

10.2741/s65 ◽  
2010 ◽  
Vol S2 (1) ◽  
pp. 299-312 ◽  
Author(s):  
Mario Testini
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide

Parathyroid hormone-related peptide, measured by a midmolecule radioimmunoassay, in various hypercalcaemic and normocalcaemic conditions

1992 ◽  
Vol 127 (4) ◽  
pp. 294-300 ◽  
Author(s):  
Elisabet Bucht ◽  
Anders Eklund ◽  
Göran Toss ◽  
Rolf Lewensohn ◽  
Barbro Granberg ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Elevated Serum ◽  
Skeletal Metastases ◽  
Endocrine Diseases ◽  
Related Peptide ◽  
Silica Cartridge ◽  
The Subject ◽  
Parathyroid Hormone Related Peptide ◽  
Made In

The diagnosis of humoral hypercalcaemia of malignancy often presents considerable clinical problems. We have studied parathyroid hormone-related peptide (PTHrP) in serum from patients with humoral hypercalcaemia of malignancy (N=22), hypercalcaemia of malignancy with skeletal metastases(1 7), histologically confirmed primary hyperparathyroidism (21) and hypercalcaemic patients with various benign diseases (9). PTHrP measurements were also made in normocalcaemic patients with various malignancies (23), endocrine diseases (13), sarcoidosis (22) and chronic renal failure (17). PTHrP was measured by a novel radioimmunoassay using rabbit antibodies directed towards the midregion of the molecule. Immuno- or silica cartridge extraction of serum before radioimmunoassay enabled us to measure PTHrP in all samples, which may add further information about circulating forms of PTHrP. PTHrP was clearly elevated in patients with humoral hypercalcaemia of malignancy (5.0±4.7 pmol/l) (mean±sd, N=12) and when the kidney function was impaired (4.0±0.9 pmol/l) (N=15) (silica cartridge extraction), whether the subject was hyperalcaemic or not. Some patients with endocrine diseases, including two with primary hyperparathyroidism, had slightly elevated serum PTHrP concentrations, while they were normal in sarcoidosis. In healthy subjects the levels were 1.1±0.5 pmol/1 (N= 15) after immunoextraction and 0.8±0.2 pmol/l(N= 33) after silica cartridge extraction.

Parathyroid Hormone-Related Peptide-Secreting Pancreatic Neuroendocrine Tumours: Case Series and Literature Review

2008 ◽  
Vol 89 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Rajaventhan Srirajaskanthan ◽  
Mary McStay ◽  
Christos Toumpanakis ◽  
Tim Meyer ◽  
Martyn E. Caplin
Keyword(s):  
Parathyroid Hormone ◽  
Literature Review ◽  
Neuroendocrine Tumours ◽  
Case Series ◽  
Related Peptide ◽  
Pancreatic Neuroendocrine Tumours ◽  
Parathyroid Hormone Related Peptide
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