Melatonin and clock genes expression in the cardiovascular system

10.2741/s404 ◽  
2013 ◽  
Vol S5 (2) ◽  
pp. 743-753 ◽  
Author(s):  
Michal Zeman
Keyword(s):  
Cardiovascular System ◽  
Clock Genes ◽  
Genes Expression

THE ROLE OF CIRCADIAN REGULATION OF GHRELIN LEVELS IN PARKINSON’S DISEASE (LITERATURE REVIEW)

2021 ◽  
Vol 74 (7) ◽  
pp. 1750-1753
Author(s):  
Kateryna A. Tarianyk ◽  
Nataliya V. Lytvynenko ◽  
Anastasiia D. Shkodina ◽  
Igor P. Kaidashev
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clock Genes ◽  
Biological Rhythms ◽  
Circadian Regulation ◽  
Diurnal Changes ◽  
Dopaminergic Therapy ◽  
Peripheral Oscillators ◽  
Genes Expression

The paper is aimed at the analysis of the role of the circadian regulation of ghrelin levels in patients with Parkinson’s disease. Based on the literature data, patients with Parkinson’s disease have clinical fluctuations in the symptoms of the disease, manifested by the diurnal changes in motor activity, autonomic functions, sleep-wake cycle, visual function, and the efficacy of dopaminergic therapy. Biological rhythms are controlled by central and peripheral oscillators which links with dopaminergic neurotransmission – core of the pathogenesis of Parkinson`s disease. Circadian system is altered in Parkinson`s disease due to that ghrelin fluctuations may be changed. Ghrelin is potential food-entrainable oscillator because it is linked with clock genes expression. In Parkinson`s disease this hormone may induce eating behavior changing and as a result metabolic disorder. The “hunger hormone” ghrelin can be a biomarker of the Parkinson’s disease, and the study of its role in the pathogenesis, as well as its dependence on the period of the day, intake of levodopa medications to improve the effectiveness of treatment is promising.

scholarly journals Sexual Dimorphism in Clock Genes Expression in Human Adipose Tissue

2011 ◽  
Vol 22 (1) ◽  
pp. 105-112 ◽  
Author(s):  
P. Gómez-Abellán ◽  
J. A. Madrid ◽  
J. A. Luján ◽  
M. D. Frutos ◽  
R. González ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sexual Dimorphism ◽  
Clock Genes ◽  
Human Adipose Tissue ◽  
Genes Expression

Sleep Deprivation Induces Neuroinflammation and Depressive-like Behaviors by Impairing the Regulation of Circadian Clock Genes Expression in Rats

2020 ◽  
Author(s):  
Chen Xing ◽  
Yanzhao Zhou ◽  
Huan Xu ◽  
Mengnan Ding ◽  
Yifan Zhang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Circadian Clock ◽  
Glial Cell ◽  
Hpa Axis ◽  
Calcium Binding ◽  
Cell Activation ◽  
Clock Genes ◽  
Sleep Loss ◽  
Genes Expression ◽  
Circadian Clock Genes

Abstract Background: Sleep loss leads to a spectrum of mood disorders such as anxiety, cognitive dysfunction and motor coordination impairment in many individuals. However, the underlying mechanisms are largely unknown. Methods: In this study, we examined the effects of sleep deprivation (SD) on depression and the mechanism by subjecting rats to a slowly rotating platform for 3 days to mimic the process of sleep loss. Sleep-deprived animals were tested behaviorally for anxiety- and depressive-like behaviors. We further studied the effects of SD on hypothalamic-pituitary-adrenal (HPA) axis activity, and at the end of the experiment, brains were collected to measure the circadian clock genes expression in the hypothalamus, glial cell activation and inflammatory cytokine alterations. Results: Our results indicated that SD for 3 days resulted in anxiety- and depressive-like behaviors. SD exaggerated cortisol response to HPA axis, significantly altered the mRNA profile of circadian clock genes, and induced neuroinflammation by increasing the expression of glial cell markers, including the microglial marker ionized calcium-binding adapter molecule 1 (Iba1) and the astroglial marker glial fibrillary acidic protein (GFAP). The expression of M1 and M2 microglial markers (Arg-1 and CD206, respectively) and pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) were increased in the brain. Conclusion: These results indicated that SD for 3 days induced anxiety- and depression-like behaviors in rats by impairing the regulation of circadian clock genes and inducing neuroinflammation, ultimately resulting in brain injury.

scholarly journals The nutrigenomic investigation of C57BL/6N mice fed a short-term high-fat diet highlights early changes in clock genes expression

2013 ◽  
Vol 8 (5) ◽  
pp. 465-474 ◽  
Author(s):  
Michela Lizier ◽  
Lorenzo Bomba ◽  
Andrea Minuti ◽  
Fatima Chegdani ◽  
Jessica Capraro ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Clock Genes ◽  
High Fat ◽  
Short Term ◽  
Genes Expression

P.3.b.016 Effect of haloperidol and olanzapine on clock genes expression – preliminary results

2015 ◽  
Vol 25 ◽  
pp. S472
Author(s):  
L. Mokros ◽  
M. Karbownik ◽  
K. Nowakowska-Domagala ◽  
J. Szemraj ◽  
W. Lukasz ◽  
...  
Keyword(s):  
Clock Genes ◽  
Preliminary Results ◽  
Genes Expression

Abolished Daily Expression Patterns of SIRT1, SIRT2, and SIRT5 in Human Chronic Myeloid Leukemia

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4613-4613
Author(s):  
Ming-Yu Yang ◽  
Pai-Mei Lin ◽  
Jui-Feng Hsu ◽  
Wen-Chi Yang ◽  
Yi-Chang Liu ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Circadian Rhythms ◽  
Circadian Clock ◽  
Myeloid Leukemia ◽  
Clock Genes ◽  
Expression Patterns ◽  
Healthy Individuals ◽  
Daily Pattern ◽  
Genes Expression ◽  
Circadian Clock Genes

Abstract Abstract 4613 Circadian rhythms regulate various functions of human body and disruption of circadian rhythm has been associated with cancer development and tumor progression. Circadian clock genes use transcriptional-translational feedback loops to control circadian rhythms. Many transcriptional regulators are histone acetyltransferases (HAT) or histone deacetylases (HDAC). As clock function and integration of inputs rely on transcriptional regulation, it is possible that chromatin is remodeled during circadian cycles and in response to signals that regulate the clock. SIRT1 (sirtuin 1) is a HDAC that has recently been identified as a crucial modulator of the circadian clock machinery. To date, at least 7 SIRT genes (SIRT1–7) have been identified. In our previous report we have demonstrated the daily expression patterns of PER1, PER2, PER3, CRY1, CRY2, and CKIe in peripheral blood (PB) of healthy individuals were abolished in chronic myeloid leukemia (CML) patients and partial recoveries of daily patterns were observed in CML patients with complete cytogenetic response (CCyR) and major molecular response (MMR) post-imatinib treatment [J Biol Rhythms 2011]. In this study we further investigated the expression profiles of the 7 SIRT genes (SIRT1–7) in PB total leukocytes from 49 CML and 22 healthy volunteers. Collection of PB was carried out at four time points: 2000 h, 0200 h, 0800 h, and 1400 h, respectively. In PB total leukocytes of healthy individuals, the daily pattern of SIRT1 (p < 0.01) and SIRT5 (p < 0.05) expression level peaked at 0200 h, and SIRT2 (p < 0.01) peaked at 0800 h. Daily pattern expression of these 3 genes was abolished in newly diagnosed pre-imatinib mesylate treated and blast crisis-phase CML patients. Partial daily patterns of gene expression recoveries were observed in CML patients with CCyR and MMR. In some serial monitored individual patients, the recoveries of oscillations of SIRT1, 2, and 5 genes expression accompanied with the disappearance of BCR-ABL transcripts were also noted. The expression of SIRT3, 6, and 7 did not show a time-dependent variation among the healthy and CML patients. SIRT4 expression was undetectable both in the healthy and CML patients. Updated in vitro study results of the regulation of SIRT1, 2, and 5 genes on circadian clock genes expression will be presented at the meeting. Disclosures: No relevant conflicts of interest to declare.

Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A–deficient rats

2014 ◽  
Vol 34 (4) ◽  
pp. 326-335 ◽  
Author(s):  
Lorena S. Navigatore-Fonzo ◽  
Silvia M. Delgado ◽  
Rebeca S. Golini ◽  
Ana C. Anzulovich
Keyword(s):  
Locomotor Activity ◽  
Circadian Rhythms ◽  
Vitamin A ◽  
Clock Genes ◽  
Genes Expression

scholarly journals Short-term propofol anaesthesia down-regulates clock genes expression in the master clock

2018 ◽  
Vol 35 (12) ◽  
pp. 1735-1741 ◽  
Author(s):  
Nawfel Ben-Hamouda ◽  
Vincent-Joseph Poirel ◽  
Garance Dispersyn ◽  
Paul Pévet ◽  
Etienne Challet ◽  
...  
Keyword(s):  
Clock Genes ◽  
Short Term ◽  
Genes Expression ◽  
Master Clock
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