Cell-cell interactions in primordial follicle assembly and development

10.2741/a893 ◽  
2002 ◽  
Vol 7 (4) ◽  
pp. d1990-1996 ◽  
Author(s):  
Michael K Skinner
Keyword(s):  
Primordial Follicle ◽  
Cell Interactions ◽  
Cell Cell

scholarly journals Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell–cell interactions during folliculogenesis

Reproduction ◽  
2008 ◽  
Vol 135 (5) ◽  
pp. 671-682 ◽  
Author(s):  
Gretchen Dole ◽  
Eric E Nilsson ◽  
Michael K Skinner
Keyword(s):  
Microarray Analysis ◽  
Granulosa Cells ◽  
Neurotrophic Factor ◽  
Primordial Follicle ◽  
Cell Interactions ◽  
Follicle Development ◽  
Antral Follicles ◽  
Theca Cells ◽  
Oocyte Cytoplasm ◽  
Cell Cell

Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line-derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from 4-day-old female rat pups were maintained in organ culture for 10 days in the absence (control) or presence of GDNF or kit ligand (KL)/stem cell factor. Ovaries treated with GDNF contained a significant increase in developing follicles, similar to that observed with KL treatment previously shown to promote follicle development. The actions of GDNF on the ovarian transcriptome were investigated with a microarray analysis. Immunohistochemical studies demonstrated that GDNF is localized to oocyte cytoplasm in follicles of all developmental stages, as well as to cumulus granulosa cells and theca cells in antral follicles. GDNF receptor α1 (GFRα1) staining was localized to oocyte cytoplasm of primordial and primary follicles, and at reduced levels in the oocytes of antral follicles. GFRα1 was present in mural granulosa cells of antral follicles, theca cells, and ovarian surface epithelium. The localization studies were confirmed with molecular analysis. Microarray analysis was used to identify changes in the ovarian transcriptome and further elucidate the signaling network regulating early follicle development. Observations indicate that GDNF promotes primordial follicle development and mediates autocrine and paracrine cell–cell interactions required during folliculogenesis. In contrast to the testis, ovarian GDNF is predominantly produced by germ cells (oocytes) rather than somatic cells.

Cell-cell interactions in diabetic neuropathy

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
I Lukic ◽  
S Stoyanov ◽  
A Erhardt ◽  
P Nawroth ◽  
A Bierhaus
Keyword(s):  
Diabetic Neuropathy ◽  
Cell Interactions ◽  
Cell Cell

scholarly journals Testicular organoids to study cell–cell interactions in the mammalian testis

Andrology ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 835-841 ◽  
Author(s):  
S. Sakib ◽  
T. Goldsmith ◽  
A. Voigt ◽  
I. Dobrinski
Keyword(s):  
Cell Interactions ◽  
Mammalian Testis ◽  
Cell Cell
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