Sex hormones in the pathogenesis of systemic lupus erythematosus

10.2741/a708 ◽  
2001 ◽  
Vol 6 (4) ◽  
pp. e193-206 ◽  
Author(s):  
Robert W McMurray
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sex Hormones ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Female sex hormones at the onset of systemic lupus erythematosus affect survival

Rheumatology ◽  
1998 ◽  
Vol 37 (9) ◽  
pp. 1008-1010 ◽  
Author(s):  
M. J. Rood ◽  
E. A. Van Der Velde ◽  
R. Ten Cate ◽  
F. C. Breedveld ◽  
T. W. Huizinga
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sex Hormones ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Female Sex ◽  
Female Sex Hormones

Abnormalities of sex hormones in men with systemic lupus erythematosus

1985 ◽  
Vol 4 (4) ◽  
pp. 420-425 ◽  
Author(s):  
M. Carrabba ◽  
C. Giovine ◽  
M. Chevallard ◽  
M. Angelini ◽  
B. Ambrosi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sex Hormones ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Sex Hormones and Prolactin Levels and Their Association with Anti Cardiolipin Antibody in Patients with Systemic Lupus Erythematosus

2018 ◽  
Author(s):  
Dariyush Raeisi ◽  
Mohammad Erfan Zare ◽  
Atefeh Nasir Kansestani ◽  
Hamid Reza Sherkatolabbasieh ◽  
Shiva Shafiezadeh
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sex Hormones ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Serum Levels ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus ◽  
Female Patients ◽  
Significant Difference

Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. The aim of present study was to assess the serum levels of anticardiolipin antibody (ACA), sex hormones and prolactin in SLE female patients and their association with the disease. This study comprised 40 SLE female patients and 41 healthy age-matched female subjects. For all patients and controls, the serum levels of ACA (IgG and IgM), estradiol, testosterone, progesterone, dehydroepiandrosterone sulfate (DHEA-S) and prolactin were measured by ELISA method. Our study revealed that serum levels of testosterone, DHEA-S and progesterone were significantly lower in SLE patients than control (p<0.001). However, serum levels of estradiol and prolactin were significantly higher in SLE patients compared to controls (p<0.001). There was a significant difference between mild and moderate severity patients group for ACA positivity (95% CI 13.67-41.3; p=0.03). Also, SLE patients with positive ACA showed significantly lower (p<0.001) serum levels of testosterone, DHEA-S and progesterone and significantly higher (p<0.001) estradiol and prolactin serum levels compared to negative ACA patients. The results of our study indicated that expression and metabolism of sex hormones and prolactin are different in female SLE patients compared to healthy subjects. It seems, change in serum levels of these hormones is related to higher SLE disease activity, increased thrombotic risks and increased renal involvement.

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