The molecular basis of ovarian cell death during germ cell attrition follicular atresia and luteolysis

10.2741/a111 ◽  
1996 ◽  
Vol 1 (4) ◽  
pp. d1-11 ◽  
Author(s):  
J. L Tilly
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Molecular Basis ◽  
Follicular Atresia ◽  
Ovarian Cell

The Molecular Basis of Ovarian Cell Death

1996 ◽  
pp. 37-50 ◽  
Author(s):  
Jonathan L. Tilly ◽  
Anne N. Hirshfield
Keyword(s):  
Cell Death ◽  
Molecular Basis ◽  
Ovarian Cell

Therapeutic doses of phosphoramide mustard cause germ cell death in the prepubertal mouse testis

2016 ◽  
Author(s):  
Siobhan Rice ◽  
Ellie Smart ◽  
Federica Lopes ◽  
Rod Mitchell ◽  
Norah Spears
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Mouse Testis ◽  
Phosphoramide Mustard ◽  
Therapeutic Doses

Selenium rescues orbital fibroblasts from cell death induced by hydrogen peroxide: another molecular basis for the effects of selenium in graves’ orbitopathy

Endocrine ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 386-389 ◽  
Author(s):  
Giovanna Rotondo Dottore ◽  
Riccardo Chiarini ◽  
Maria De Gregorio ◽  
Marenza Leo ◽  
Giamberto Casini ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Molecular Basis ◽  
Graves Orbitopathy ◽  
Orbital Fibroblasts

Erratum to: Selenium rescues orbital fibroblasts from cell death induced by hydrogen peroxide: another molecular basis for the effects of selenium in graves’ orbitopathy

Endocrine ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 390-390 ◽  
Author(s):  
Giovanna Rotondo Dottore ◽  
Riccardo Chiarini ◽  
Maria De Gregorio ◽  
Marenza Leo ◽  
Giamberto Casini ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Molecular Basis ◽  
Graves Orbitopathy ◽  
Orbital Fibroblasts

scholarly journals The developing ovary of the South American plains vizcacha, Lagostomus maximus (Mammalia, Rodentia): massive proliferation with no sign of apoptosis-mediated germ cell attrition

Reproduction ◽  
2011 ◽  
Vol 141 (5) ◽  
pp. 633-641 ◽  
Author(s):  
N P Leopardo ◽  
F Jensen ◽  
M A Willis ◽  
M B Espinosa ◽  
A D Vitullo
Keyword(s):  
Germ Cell ◽  
Germ Cells ◽  
Ovarian Tissue ◽  
Tunel Assay ◽  
South American ◽  
Follicular Atresia ◽  
The South ◽  
Cell Degeneration ◽  
Lagostomus Maximus ◽  
Apoptotic Activity

Apoptosis-dependent massive germ cell death is considered a constitutive trait of the developing mammalian ovary that eliminates 65–85% of the germinal tissue depending on the species. After birth and during adult lifetime, apoptotic activity moves from the germ cell proper to the somatic compartment, decimating germ cells through follicular atresia until the oocyte reserve is exhausted. In contrast, the South American rodent Lagostomus maximus shows suppressed apoptosis-dependent follicular atresia in the adult ovary, with continuous folliculogenesis and massive polyovulation, which finally exhausts the oocyte pool. The absence of follicular atresia in adult L. maximus might arise from a failure to move apoptosis from the germinal stratum to the somatic compartment after birth or being a constitutive trait of the ovarian tissue with no massive germ cell degeneration in the developing ovary. We tested these possibilities by analysing oogenesis, expression of germ cell-specific VASA protein, apoptotic proteins BCL2 and BAX, and DNA fragmentation by TUNEL assay in the developing ovary of L. maximus. Immunolabelling for VASA revealed a massive and widespread colonisation of the ovary and proliferation of germ cells organised in nests that disappeared at late development when folliculogenesis began. No sign of germ cell attrition was found at any time point. BCL2 remained positive throughout oogenesis, whereas BAX was slightly detected in early development. TUNEL assay was conspicuously negative throughout the development. These results advocate for an unrestricted proliferation of germ cells, without apoptosis-driven elimination, as a constitutive trait of L. maximus ovary as opposed to what is normally found in the developing mammalian ovary.

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