CpG-oligonucleotides for cancer immunotherapy review of the literature and potential applications in malignant glioma

10.2741/934 ◽  
2003 ◽  
Vol 8 (5) ◽  
pp. e115-127 ◽  
Author(s):  
Antoine F Carpentier
Keyword(s):  
Malignant Glioma ◽  
Cancer Immunotherapy ◽  
Review Of The Literature ◽  
Cpg Oligonucleotides ◽  
Potential Applications

scholarly journals Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature

2014 ◽  
Vol 2014 (1) ◽  
pp. 1-4 ◽  
Author(s):  
M. P. Christman ◽  
S. E. Turbett ◽  
S. Sengupta ◽  
K. U. Bakhadirov ◽  
C. A. Williamson ◽  
...  
Keyword(s):  
Case Report ◽  
Herpes Simplex ◽  
Malignant Glioma ◽  
Herpes Simplex Encephalitis ◽  
Review Of The Literature

scholarly journals Metamaterials for Microwave Radomes and the Concept of a Metaradome: Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
E. Öziş ◽  
A. V. Osipov ◽  
T. F. Eibert
Keyword(s):  
Aerodynamic Drag ◽  
Antenna System ◽  
Antenna Design ◽  
Review Of The Literature ◽  
Open Problems ◽  
Mechanical Parts ◽  
Artificial Materials ◽  
Potential Applications ◽  
Band Pass ◽  
Frequency Behavior

A radome is an integral part of almost every antenna system, protecting antennas and antenna electronics from hostile exterior conditions (humidity, heat, cold, etc.) and nearby personnel from rotating mechanical parts of antennas and streamlining antennas to reduce aerodynamic drag and to conceal antennas from public view. Metamaterials are artificial materials with a great potential for antenna design, and many studies explore applications of metamaterials to antennas but just a few to the design of radomes. This paper discusses the possibilities that metamaterials open up in the design of microwave radomes and introduces the concept of metaradomes. The use of metamaterials can improve or correct characteristics (gain, directivity, and bandwidth) of the enclosed antenna and add new features, like band-pass frequency behavior, polarization transformations, the ability to be switched on/off, and so forth. Examples of applications of metamaterials in the design of microwave radomes available in the literature as well as potential applications, advantages, drawbacks, and still open problems are described.

scholarly journals Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy

2019 ◽  
Vol 3 (2) ◽  
pp. 76
Author(s):  
Wei Boon Yap ◽  
Shaktypreya Nadarajah ◽  
Nadiah Shidik ◽  
Noorjahan Banu Mohammed Alitheen
Keyword(s):  
Cell Growth ◽  
Cancer Therapy ◽  
Cancer Immunotherapy ◽  
Cancer Cell ◽  
Therapeutic Approach ◽  
Future Prospects ◽  
Cancer Cell Growth ◽  
Alternative Therapeutic Approach ◽  
Potential Applications ◽  
Cancer Immunotherapeutic

Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer functions; hence, its potential roles in cancer immunotherapy. Although proven to be effective against cancer cell growth and angiogenesis, given its dual immune-regulating functions (pro-inflammatory and anti-inflammatory), the use of IL-27 as a cancer immunotherapeutic cytokine could possibly be a two-edged sword without meticulous and thorough research. This mini-review mainly discusses the functions and future prospects of IL-27 as an effective anticancer cytokine. Hopefully, it imparts useful insights into the potential applications of IL-27 in cancer immunotherapy

Symptomatic Spinal Metastases from Intracranial High-grade Glioma – Report of Four Cases and Review of the Literature

2012 ◽  
Vol 08 (04) ◽  
pp. 213 ◽  
Author(s):  
James Powell ◽  
Keyword(s):  
Malignant Glioma ◽  
Median Overall Survival ◽  
Spinal Metastases ◽  
High Grade Glioma ◽  
Neurological Deficits ◽  
Review Of The Literature ◽  
Neurological Signs ◽  
The Mean ◽  
Clinical Awareness ◽  
Radiotherapy Treatment

Intraspinal (leptomeningeal or intramedullary) metastases from primary intracranial gliomas have been well documented in several clinical and pathological series; however, symptomatic intraspinal metastases remain rare. We conducted a retrospective search of cases of intraspinal metastases treated at our centre and report four cases of symptomatic intraspinal leptomeningeal and intramedullary metastases from an intracranial glioma. The mean age of the four cases was 43 years (range 28–55 years). The intraspinal metastases were detected after a median time of 18.5 months after onset of the disease and the median survival time of the four patients from detection of spinal metastases was one month. Median overall survival of the four patients was 19 months. One patient was treated with surgery and all received radiotherapy treatment. Radiotherapy provided good initial palliation of pain but improvement in neurological deficits was limited.Overall, prognosis in cases of leptomeningeal and intramedullary metastases from primary intracranial glioma is very poor; however, this diagnosis should be considered in patients with malignant glioma presenting with new back pain and/or associated spinal neurological signs or symptoms. Radiotherapy provided relief of pain and some improvement in neurological function but no survival advantage. Clinical awareness and recognition of this entity will become increasingly important as local control of primary malignant glioma improves and corresponding improvements in outcome and prognosis of this disease are observed.

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