scholarly journals Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma

10.2741/4913 ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 692-705
Author(s):  
Ruyue Tian
Keyword(s):  
Tumor Microenvironment ◽  
Serous Adenocarcinoma ◽  
Prognostic Gene ◽  
Gene Profiles ◽  
Ovarian Serous Adenocarcinoma

THE ASSOCIATION OF THE APOLIPOPROTEIN E4 ALLELE (RS 429358) WITH OVARIAN SEROUS ADENOCARCINOMA

2017 ◽  
Vol 63 (4) ◽  
pp. 627-631
Author(s):  
Tatyana Ivanova ◽  
Nataliya Sychenkova ◽  
Vera Khorokhorina ◽  
Nikolay Ryabchenko ◽  
Sergey Ivanov ◽  
...  
Keyword(s):  
Older Women ◽  
Odds Ratio ◽  
Area Under Curve ◽  
Reproductive Age ◽  
Prognostic Indicators ◽  
Separate Analysis ◽  
Women Of Reproductive Age ◽  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma ◽  
E4 Allele

The distribution of APOE 4 allele (rs 429358, C) was analyzed in healthy women (N=454) and patients with ovarian serous adenocarcinoma (N=114) in order to identify genetic predisposition to the disease. We determined the prognostic indicators of the E4 allele as a marker: odds ratio (OR) and AUC (Area Under Curve) - an area under the ROC curve. It was shown that APOE 4 allele was significantly associated with ovarian serous adenocarcinoma (p = 0,003; 0R=1,94; AUC=0,55). The Е4 genotypes frequency was significantly increased among patients (p = 0.02; 0R=1,8). Separate analysis of the two age subgroups (over 46 years and younger) found that the chance of developing ovarian serous adenocarcinoma was significantly increased for older women (p = 0,006; OR = 2,24, AUC = 0,76). Possible associations of APOE 4 with the ovarian serous adenocarcinoma in women of reproductive age deserve further studying.

Ovarian carcinoma in a 14-year-old with classical salt-wasting congenital adrenal hyperplasia and bilateral adrenalectomy

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Christian Pina ◽  
Ahmed Khattab ◽  
Philip Katzman ◽  
Lauren Bruckner ◽  
Jeffrey Andolina ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Ovarian Carcinoma ◽  
Left Ovary ◽  
Bilateral Adrenalectomy ◽  
Ca 125 ◽  
Adrenal Hyperplasia ◽  
Serous Adenocarcinoma ◽  
Adrenal Tissue ◽  
Ovarian Serous Adenocarcinoma ◽  
21 Hydroxylase Deficiency

AbstractA 14-year-old female with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency underwent bilateral adrenalectomy at 6 years of age as a result of poor hormonal control. Because the patient was adrenalectomized, extra adrenal androgen production was suspected. Imaging studies including pelvic ultrasound and pelvic magnetic resonance imaging (MRI) were obtained to evaluate for adrenal rest tumors of the ovaries. Abdominal MRI was obtained to evaluate for residual adrenal tissue. A cystic lesion arising from her right ovary suspicious for ovarian neoplasm was noted on pelvic MRI. Right salpingo-oophorectomy was performed and histopathological examination revealed ovarian serous adenocarcinoma, low-grade, and well-differentiated. Tumor marker CA-125 was elevated and additional ovarian cancer staging workup confirmed stage IIIC due to one lymph node positive for carcinoma. The patient then developed a large left ovarian cyst, which led to a complete total abdominal hysterectomy and removal of the left ovary and fallopian tube. Pathology confirmed ovarian serous adenocarcinoma with microscopic focus of carcinoma in the left ovary. After numerous complications, the patient responded well to chemotherapy, CA-125 levels fell and no evidence of carcinoma was observed on subsequent imaging. To our knowledge, this is the first reported case of an ovarian serous adenocarcinoma in a patient with CAH. Although rare, we propose that the ovaries were the origin of androgen production and not residual adrenal tissue. The relationship between CAH and ovarian carcinomas has yet to be established, but further evaluation is needed given the poor survival rate of high-grade serous ovarian carcinoma.

scholarly journals Immune Landscape of the Tumor Microenvironment Identifies Prognostic Gene Signature CD4/CD68/CSF1R in Osteosarcoma

2020 ◽  
Vol 10 ◽  
Author(s):  
Yi-jiang Song ◽  
Yanyang Xu ◽  
Xiaojun Zhu ◽  
Jianchang Fu ◽  
Chuangzhong Deng ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Gene Signature ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

Cytologic findings in peritoneal fluids from patients with ovarian serous adenocarcinoma

1986 ◽  
Vol 2 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Masamichi Kashimura ◽  
Keita Matsukuma ◽  
Toshiharu Kamura ◽  
Toshitaka Matsuyama ◽  
Naoki Tsukamoto
Keyword(s):  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma

scholarly journals Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma

2011 ◽  
Vol 130 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Osamu Maeda ◽  
Kiyosumi Shibata ◽  
Satoyo Hosono ◽  
Sawako Fujiwara ◽  
Hiroaki Kajiyama ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Anticancer Drug ◽  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma ◽  
Anticancer Drug Resistance

scholarly journals Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients

2009 ◽  
Vol 2 (1) ◽  
pp. 19 ◽  
Author(s):  
Michael F Gallagher ◽  
Richard J Flavin ◽  
Salah A Elbaruni ◽  
Jamie K McInerney ◽  
Paul C Smyth ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonal Carcinoma ◽  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma
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