Drug release kinetics from a drug-eluting stent with asymmetrical coat

10.2741/4491 ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 407-415 ◽  
Author(s):  
Egon Toft
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Drug Eluting Stent ◽  
Drug Release Kinetics ◽  
Drug Eluting

Drug release kinetics from biodegradable UV-transparent hollow calcium-phosphate glass fibers

2017 ◽  
Vol 191 ◽  
pp. 116-118 ◽  
Author(s):  
Edoardo Ceci-Ginistrelli ◽  
Carlotta Pontremoli ◽  
Diego Pugliese ◽  
Nadia Barbero ◽  
Nadia G. Boetti ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Phosphate Glass ◽  
Release Kinetics ◽  
Glass Fibers ◽  
Drug Release Kinetics

scholarly journals Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport Through the Arterial Wall after Stenting

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  
Keyword(s):  
Drug Release ◽  
Arterial Wall ◽  
Release Kinetics ◽  
Artery Wall ◽  
Vascular Stents ◽  
Drug Eluting ◽  
Fiber Breaks ◽  
Stent Diameter ◽  
Stent Coating

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent

2008 ◽  
Vol 85A (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Kishore Udipi ◽  
Mingfei Chen ◽  
Peiwen Cheng ◽  
Kevin Jiang ◽  
Diane Judd ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymer System ◽  
Drug Eluting Stent ◽  
Next Generation ◽  
Biocompatible Polymer ◽  
Drug Eluting

scholarly journals Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

2021 ◽  
Vol 20 (4) ◽  
pp. 565-576
Author(s):  
Nour Al Sawaftah ◽  
Vinod Paul ◽  
Nahid Awad ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cancer Drug ◽  
Drug Release Kinetics ◽  
Anti Cancer
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