The role of BRCA1 and BRCA2 in prostate cancer

10.2741/4191 ◽  
2013 ◽  
Vol 18 (4) ◽  
pp. 1445 ◽  
Author(s):  
Roy Jensen
Keyword(s):  
Prostate Cancer ◽  
Brca1 And Brca2

scholarly journals The role of BRCA1 and BRCA2 in prostate cancer

2012 ◽  
Vol 14 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Elena Castro ◽  
Rosalind Eeles
Keyword(s):  
Prostate Cancer ◽  
Brca1 And Brca2

The Role of BRCA Testing in Hereditary Pancreatic and Prostate Cancer Families

2019 ◽  
pp. 79-86 ◽  
Author(s):  
Robert Pilarski
Keyword(s):  
Prostate Cancer ◽  
Parp Inhibitors ◽  
Gleason Grade ◽  
Brca1 And Brca2 ◽  
Direct Evaluation ◽  
Panel Testing ◽  
Post Test ◽  
Uncertain Significance ◽  
Prostate Cancers

Beyond breast and ovarian cancers, mutations in the BRCA1 and BRCA2 genes increase risks for pancreatic and prostate cancers and contribute to the prevalence of these cancers. Mutations in a number of other genes have also been shown to increase the risk for these cancers as well. Genetic testing is playing an increasingly important role in the treatment of patients with pancreatic and prostate cancer and is now recommended for all patients with pancreatic or metastatic prostate cancer, as well as patients with high Gleason grade prostate cancer and a remarkable family history. Identification of an inherited mutation can direct evaluation of the patient for other cancer risks as well as identification and management of disease in at-risk relatives. Growing evidence suggests improved responses to PARP inhibitors and other therapies in patients with mutations in the BRCA and other DNA repair genes. Although more work must be done to clarify the prevalence and penetrance of mutations in genes other than BRCA1 and BRCA2 in patients with pancreatic and prostate cancer, in most cases, testing is now being done with a panel of multiple genes. Because of the complexities in panel testing and the increased likelihood of finding variants of uncertain significance, pre- and post-test genetic counseling are essential.

410: Cleavage of E-Cadherin and the Role of an 80KDa Fragment in the Metastatic Progression of Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 108-108
Author(s):  
Rainer Kuefer ◽  
Kathleen Day ◽  
Jonathan Rios-Doria ◽  
Matthias Hofer ◽  
Arul Chinnaiyan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metastatic Progression ◽  
E Cadherin

The role of WNT5A in tumor and tumor surrounding tissue in primary and metastatic prostate cancer

2020 ◽  
Author(s):  
W Kisel ◽  
S Conrad ◽  
S Füssel ◽  
U Sommer ◽  
GB Baretton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Surrounding Tissue

In vitro studies reveal a potential therapeutic role of the combination of biguanides and statins for the treatment of prostate cancer

2018 ◽  
Author(s):  
Vicente Herrero-Aguayo ◽  
Juan M Jimenez-Vacas ◽  
Enrique Gomez-Gomez ◽  
Antonio J Leon-Gonzalez ◽  
Prudencio Saez-Martinez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vitro Studies ◽  
Therapeutic Role ◽  
Potential Therapeutic Role

Role of exosomes in diagnosis and therapy of prostate cancer

2020 ◽  
Vol 28 (3) ◽  
pp. 399-405
Author(s):  
Fabrizio Fontana ◽  
Olga A. Babenko
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Biological Fluids ◽  
Diagnosis And Treatment ◽  
Diagnosis And Therapy ◽  
The Future ◽  
Important Direction ◽  
Potential Biomarkers

Aim of this letter is to attract the attention of journal readers to the study of exosomes as an important direction in the development of Oncology, in particular, in the diagnosis and treatment of prostate cancer. Exosomes are produced by tumor cells and regulate proliferation, metastasis, and the development of chemoresistance. Their extraction from biological fluids allows further use of these vesicles as potential biomarkers of prostate cancer. In the future, exosomes can be successfully used in the delivery of drugs and other anti-tumor substances to cancer cells.

The role of prostate HistoScanning in detecting prostate cancer

2015 ◽  
Vol 17 (7) ◽  
pp. 8-11
Author(s):  
A.V. Govorov ◽  
◽  
A.O. Vasilyev ◽  
A.V. Sadchenko ◽  
E.A. Prilepskaya ◽  
...  
Keyword(s):  
Prostate Cancer
Sign in / Sign up

Export Citation Format

Share Document