Immunosuppression and the infection caused by gut mucosal barrier dysfunction in patients with early severe acute pancreatitis

10.2741/4150 ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 892 ◽  
Author(s):  
Yuan-Long Gu
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

scholarly journals Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xia Liu ◽  
Yiwen Cheng ◽  
Li Shao ◽  
Zongxin Ling
Keyword(s):  
Colorectal Cancer ◽  
Diamine Oxidase ◽  
Early Stage ◽  
Fusobacterium Nucleatum ◽  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Beneficial Bacteria ◽  
Barrier Dysfunction ◽  
Real Time Quantitative Pcr ◽  
Gut Mucosal Barrier

Growing evidence indicated that the gut microbiota was the intrinsic and essential component of the cancer microenvironment, which played vital roles in the development and progression of colorectal cancer (CRC). In our present study, we investigated the alterations of fecal abundant microbiota with real-time quantitative PCR and the changes of indicators of gut mucosal barrier from 53 early-stage CRC patients and 45 matched healthy controls. We found that the traditional beneficial bacteria such as Lactobacillus and Bifidobacterium decreased significantly and the carcinogenic bacteria such as Enterobacteriaceae and Fusobacterium nucleatum were significantly increased in CRC patients. We also found gut mucosal barrier dysfunction in CRC patients with increased levels of endotoxin (LPS), D-lactate, and diamine oxidase (DAO). With Pearson’s correlation analysis, D-lactate, LPS, and DAO were correlated negatively with Lactobacillus and Bifidobacterium and positively with Enterobacteriaceae and F. nucleatum. Our present study found dysbiosis of the fecal microbiota and dysfunction of the gut mucosal barrier in patients with early-stage CRC, which implicated that fecal abundant bacteria and gut mucosal barrier indicators could be used as targets to monitor the development and progression of CRC in a noninvasive and dynamic manner.

NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATES AMELIORATE GUT MUCOSAL BARRIER DYSFUNCTION AND CASPASE-3/7 ACTIVATION IN RATS SUBJECTED TO HEMORRHAGIC SHOCK.

2005 ◽  
Vol 33 ◽  
pp. A32
Author(s):  
Carlos A Macias ◽  
Jeffrey W Chiao ◽  
Yulia Y Tyurina ◽  
Peter Wipf ◽  
Jingbo Xiao ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Caspase 3 ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier
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