scholarly journals Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy

10.2741/3505 ◽  
2009 ◽  
Vol Volume (14) ◽  
pp. 3974 ◽  
Author(s):  
Ling Zheng
Keyword(s):  
Nitric Oxide ◽  
Diabetic Retinopathy

scholarly journals Multiscale modeling and simulation of neurovascular coupling in the retina

2018 ◽  
Vol 2 (2) ◽  
pp. 30-35
Author(s):  
Riccardo Sacco ◽  
Aurelio G. Mauri ◽  
Alessandra Cardani ◽  
Brent A. Siesky ◽  
Giovanna Guidoboni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mathematical Model ◽  
Diabetic Retinopathy ◽  
Multiscale Modeling ◽  
Neurovascular Coupling ◽  
Retinal Arterioles ◽  
Potent Vasodilator ◽  
Simulation Results ◽  
Flicker Light

The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal neurovascular coupling is still elusive. Measurements of flicker light-induced functional hyperemia (FH) in humans show that an increase of NO levels reduces vasodilation. This evidence has led to conjecture that such an increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy. In this paper, we propose a mathematical model to theoretically investigate the effect of an increase in neural NO (nNO) on the vasodilation of retinal arterioles. Simulation results indicate that nNO increase may:1. significantly aff ect vasoconstrictive agent production by glial cells; and2. elicit vasoconstriction rather than vasodilation in retinal arterioles.Model predictions seem therefore to support the conjecture that NO increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy.

Oxidative Stress in Galactose Induced Diabetic Retinopathy in Inducible Nitric Oxide Synthase Knockout Mice

2001 ◽  
Vol 7 (S2) ◽  
pp. 638-639
Author(s):  
E. Ann Ellis ◽  
Maria B. Grant
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Diabetic Retinopathy ◽  
Inducible Nitric Oxide Synthase ◽  
Knockout Mice ◽  
Oxide System ◽  
Oxide Synthase ◽  
Nitric Oxide System ◽  
Inducible Nitric Oxide

Oxidative stress and inducible nitric oxide synthase (iNOS) have been implicated in endothelial cell dysfunction in diabetic retinopathy by formation of peroxynitrite, a cytotoxic product of superoxide and high levels of nitric oxide. Spontaneous diabetic models do not allow for separating the oxidative stress as a result of hyperglycemia from that of the nitric oxide system. in addition chemicals such as streptozotocin which can induce diabetes in animal models cause oxidative stress and induce iNOS before the onset of hyperglycemia. Galactose has been used to induce non-insulin dependent diabetes in mice and rats while gene knockout mice provide a means to study the role of specific NOS components. This study used cytochemical localization of hydrogen peroxide produced by NADH oxidase, a marker for superoxide production, and immunocytochemical localization of nitrotyrosine, a marker for nitric oxide formed radical peroxynitrite, to investigate the role of oxidative stress and the nitric oxide system in galactose induced diabetic retinopathy in iNOS knockout (iNOS%) mice.

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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