scholarly journals Regulation of asymmetric stem cell division: spindle orientation and the centrosome

10.2741/3430 ◽  
2009 ◽  
Vol Volume (14) ◽  
pp. 3003 ◽  
Author(s):  
Yukiko, M. Yamashita
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Spindle Orientation ◽  
Division Spindle ◽  
Stem Cell Division

scholarly journals Novel insights into mammalian embryonic neural stem cell division: focus on microtubules

2015 ◽  
Vol 26 (24) ◽  
pp. 4302-4306 ◽  
Author(s):  
Felipe Mora-Bermúdez ◽  
Wieland B. Huttner
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Spindle Orientation ◽  
Stem Cell Divisions ◽  
A Cell ◽  
Spindle Microtubules ◽  
Stem Cell Division ◽  
Embryonic Neural Stem Cell

During stem cell divisions, mitotic microtubules do more than just segregate the chromosomes. They also determine whether a cell divides virtually symmetrically or asymmetrically by establishing spindle orientation and the plane of cell division. This can be decisive for the fate of the stem cell progeny. Spindle defects have been linked to neurodevelopmental disorders, yet the role of spindle orientation for mammalian neurogenesis has remained controversial. Here we explore recent advances in understanding how the microtubule cytoskeleton influences mammalian neural stem cell division. Our focus is primarily on the role of spindle microtubules in the development of the cerebral cortex. We also highlight unique characteristics in the architecture and dynamics of cortical stem cells that are tightly linked to their mode of division. These features contribute to setting these cells apart as mitotic “rule breakers,” control how asymmetric a division is, and, we argue, are sufficient to determine the fate of the neural stem cell progeny in mammals.

scholarly journals Regulating the balance between symmetric and asymmetric stem cell division in the developing brain

Fly ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Boris Egger ◽  
Katrina S. Gold ◽  
Andrea H. Brand
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Developing Brain ◽  
Stem Cell Division
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