NADPH treatment decreases C6 glioma cell survival by increasing oxidative stress

10.2741/325 ◽  
2009 ◽  
Vol E3 (1) ◽  
pp. 1221
Author(s):  
Yingxin Ma
2011 ◽  
Vol 32 (5) ◽  
pp. 619-625 ◽  
Author(s):  
Wen-hai Fan ◽  
Yi Hou ◽  
Fan-kai Meng ◽  
Xiao-fei Wang ◽  
Yi-nan Luo ◽  
...  

1990 ◽  
Vol 72 (5) ◽  
pp. 782-785 ◽  
Author(s):  
Justin D. Cohen ◽  
H. Ian Robins ◽  
Manucher J. Javid

✓ The cytotoxic, antiproliferative, and radiosensitizing effects of thymidine (a nucleoside metabolite) were studied using the C6 glioma cell line in vitro. Radiosensitization by a combination of thymidine and 41.8°C hyperthermia was also evaluated. Thymidine concentrations above 100 µg/ml completely inhibited C6 proliferation while concentrations of 100 to 1000 µg/ml (for up to 24 hours) decreased C6 cell survival to as little as 7.4% compared to untreated control cells. Radiosensitivity was enhanced by the administration of thymidine alone (400 µg/ml × 24 hours before irradiation); sensitization by 41.8°C hyperthermia alone (1 hour ending immediately before irradiation) was less pronounced. Thymidine and hyperthermia together produced greater radiosensitization than did heat alone or thymidine alone. These data support the further investigation of thymidine as a neuro-oncology radiosensitizer.


2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Cuiping Zhao ◽  
Heyu Chen ◽  
Weiliang Xia ◽  
Shengtian Li ◽  
Weihai Ying

Neuroscience ◽  
2005 ◽  
Vol 134 (2) ◽  
pp. 567-574 ◽  
Author(s):  
I. Goncharov ◽  
L. Weiner ◽  
Z. Vogel

Author(s):  
Andréa Gisiane Kurek Ferreira ◽  
Helena Biasibetti-Brendler ◽  
Daniele Susana Volkart Sidegum ◽  
Samanta Oliveira Loureiro ◽  
Fabrício Figueiró ◽  
...  

Biomaterials ◽  
2010 ◽  
Vol 31 (24) ◽  
pp. 6201-6206 ◽  
Author(s):  
Ping Wang ◽  
Lei Li ◽  
Cheng Zhang ◽  
Qunfang Lei ◽  
Wenjun Fang

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