New insights in drug development for the non-small cell lung cancer therapy

10.2741/3067 ◽  
2008 ◽  
Vol Volume (13) ◽  
pp. 5108 ◽  
Author(s):  
Cesare Gridelli
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Drug Development ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Therapy

Histotype in Non-Small Cell Lung Cancer Therapy and Staging: The Emerging Role of an Old and Underrated Factor

2007 ◽  
Vol 3 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Giulio Rossi ◽  
Alessandro Marchioni ◽  
Giuliana Sartori ◽  
Lucia Longo ◽  
Silvia Piccinini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Therapy

scholarly journals Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Syed Hassan Abbas Naqvi ◽  
Syed Hassan Shiraz Naqvi ◽  
Muhammad Yasin Bandukda ◽  
Syed Mumtaz Ali Naqvi
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Present Status ◽  
Small Cell ◽  
Hedgehog Pathway ◽  
Small Cell Lung ◽  
Lung Cancer Therapy

scholarly journals Epidermal growth factor-based cancer vaccine for non-small-cell lung cancer therapy

2003 ◽  
Vol 14 (3) ◽  
pp. 461-466 ◽  
Author(s):  
G. Gonzalez ◽  
T. Crombet ◽  
F. Torres ◽  
M. Catala ◽  
L. Alfonso ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Epidermal Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Therapy ◽  
Epidermal Growth

Designed DNA nanostructure grafted with erlotinib for non-small-cell lung cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (47) ◽  
pp. 23953-23958
Author(s):  
Yuqi Wang ◽  
Jin Cheng ◽  
Di Zhao ◽  
Yan Liu ◽  
Tao Luo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Schematic Representation ◽  
Dna Nanostructure ◽  
Lung Cancer Therapy ◽  
Inhibition Of Tumor Growth

Schematic representation of designed DNA nanostructure grafted with erlotinib and enhanced inhibition of tumor growth for non-small-cell lung cancer (NSCLC).

Development of Gemcitabine Loaded PLGA/Lecithin Nanoparticles for Non-Small Cell Lung Cancer Therapy

2020 ◽  
Vol 17 (7) ◽  
pp. 622-628
Author(s):  
Ozgur Esim ◽  
Cansel K. Ozkan ◽  
Meral Sarper ◽  
Ayhan Savaser ◽  
Yalcin Ozkan
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Plga Nanoparticles ◽  
Small Cell ◽  
Glycol Succinate ◽  
Small Cell Lung ◽  
Cytotoxicity Studies ◽  
Lung Cancer Therapy

Background: Compared to polymeric nanoparticles prepared using non-lipid surfactants, lecithin addition forms larger nanoparticles and exhibits higher drug loading and the stability of nanoparticles can be conferred by adding Vitamin E Polyethylene Glycol Succinate (TPGS) into the formulation. Aim: The aim of this study is to prepare Gemcitabine (Gem) loaded lecithin/PLGA nanoparticles. Moreover, the effect of TPGS and sodium cholate (SK) on the preparation of lecithin/PLGA nanoparticles was compared. Methods: It was found that while PC addition into PLGATPGS nanoparticles formed larger particles (251.3± 6.0 nm for Gem-PLGATPGS NPs and 516,9 ± 3.9 nm for Gem-PLGA-PCTPGS NPs), the particle size of PLGASK nanoparticles was not affected by lecithin addition (p>0.05). Results: In cytotoxicity studies, it was found that the SK-MES-1 cell inhibition rates of Gem-PLGATPGS NPs, Gem-PLGA-PCTPGS NPs, Gem-PLGASK NPs, Gem-PLGA-PCSK NPs were similar with free Gem (p>0.05). In cytotoxicity studies, it was found that the encapsulation into nanoparticles did not change the cytotoxicity of the drug. However, higher cellular uptake has been observed when the lecithin was used in the preparation of PLGA nanoparticles. Conclusion: Compared with free Gem, the Gem-loaded nanoparticles enhanced the uptake of the drug by SK-MES-1 cells which can increase the effect of gemcitabine for non-small cell lung cancer therapy.

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