scholarly journals Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia

10.2741/2889 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 2833 ◽  
Author(s):  
Ines, P. Koerner
Keyword(s):  
Cerebral Ischemia ◽  
Inflammatory Response ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase

scholarly journals Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia

Stroke ◽  
2008 ◽  
Vol 39 (7) ◽  
pp. 2073-2078 ◽  
Author(s):  
Wenri Zhang ◽  
Takashi Otsuka ◽  
Nobuo Sugo ◽  
Ardi Ardeshiri ◽  
Yazan K. Alhadid ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Epoxide Hydrolase ◽  
Gene Deletion ◽  
Soluble Epoxide Hydrolase ◽  
Experimental Cerebral Ischemia

scholarly journals Role of Soluble Epoxide Hydrolase in the Sex-Specific Vascular Response to Cerebral Ischemia

2009 ◽  
Vol 29 (8) ◽  
pp. 1475-1481 ◽  
Author(s):  
Wenri Zhang ◽  
Jeffrey J Iliff ◽  
Caitlyn J Campbell ◽  
Ruikang K Wang ◽  
Patricia D Hurn ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Ischemia ◽  
Infarct Size ◽  
Epoxide Hydrolase ◽  
Focal Cerebral Ischemia ◽  
Soluble Epoxide Hydrolase ◽  
Artery Occlusion ◽  
Male Mice ◽  
Key Enzyme

Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen. We determined if the sex difference in blood flow during focal cerebral ischemia is linked to sEH. Soluble epoxide hydrolase expression in brain, hydrolase activity in cerebral vessels, and plasma 14,15-dihydroxyeicosatrienoic acid (14,15-DHET) were determined in male and female wild-type (WT) and sEH knockout (sEHKO) mice. Male, female, and ovariectomized female WT and sEHKO mice were subjected to 2-h middle cerebral artery occlusion (MCAO) and infarct size was measured at 24 h of reperfusion. Laser—Doppler cortical perfusion during MCAO was compared among groups and differences in cortical blood flow rates were confirmed using in vivo quantitative optical microangiography. Cerebrovascular expression and activity of sEH and plasma 14,15-DHET were lower in WT female than male mice, and blood flow during MCAO was higher and infarct size was smaller in WT female compared with male mice. Sex differences in cerebral blood flow and ischemic damage were abolished after ovariectomy and were absent in sEHKO mice. We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia.

scholarly journals Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ranran Tu ◽  
Jillian Armstrong ◽  
Kin Sing Stephen Lee ◽  
Bruce D. Hammock ◽  
Adam Sapirstein ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Epoxide Hydrolase ◽  
Focal Cerebral Ischemia ◽  
Soluble Epoxide Hydrolase

scholarly journals Author Correction: Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ranran Tu ◽  
Jillian Armstrong ◽  
Kin Sing Stephen Lee ◽  
Bruce D. Hammock ◽  
Adam Sapirstein ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Epoxide Hydrolase ◽  
Focal Cerebral Ischemia ◽  
Soluble Epoxide Hydrolase
Sign in / Sign up

Export Citation Format

Share Document