Role of folate receptor genes in reproduction and related cancers

10.2741/1815 ◽  
2006 ◽  
Vol 11 (1) ◽  
pp. 506 ◽  
Author(s):  
Hala Elnakat
Keyword(s):  
Folate Receptor

Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells

2021 ◽  
Author(s):  
Hongwei Chu ◽  
Changqing Wu ◽  
Qun Zhao ◽  
Rui Sun ◽  
Kuo Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Folate Receptor ◽  
Mass Spectrometry Analysis ◽  
Label Free ◽  
Spectrometry Analysis ◽  
Underlying Mechanisms ◽  
Related Proteins ◽  
Hcc Cells

Abstract Sorafenib is commonly used to treat advanced human hepatocellular carcinoma (HCC). However, clinical efficacy has been limited by drug resistance. In this study, we used label-free quantitative proteomic analysis to systematically investigate the underlying mechanisms of sorafenib resistance in HCC cells. A total of 1709 proteins were confidently quantified. Among them, 89 were differentially expressed, and highly enriched in the processes of cell-cell adhesion, negative regulation of apoptosis, response to drug and metabolic processes involving in sorafenib resistance. Notably, folate receptor α (FOLR1) was found to be significantly upregulated in resistant HCC cells. In addition, in-vitro studies showed that overexpression of FOLR1 decreased the sensitivity of HCC cells to sorafenib, whereas siRNA-directed knockdown of FOLR1 increased the sensitivity of HCC cells to sorafenib. Immunoprecipitation-mass spectrometry analysis suggested a strong link between FOLR1 and autophagy related proteins. Further biological experiments found that FOLR1-related sorafenib resistance was accompanied by the activation of autophagy, whereas inhibition of autophagy significantly reduced FOLR1-induced cell resistance. These results suggest the driving role of FOLR1 in HCC resistance to sorafenib, which may be exerted through FOLR1-induced autophagy. Therefore, this study may provide new insights into understanding the mechanism of sorafenib resistance.

The role of nanomaterials on the cancer cells sensing based on folate receptor: Analytical approach

2020 ◽  
Vol 125 ◽  
pp. 115834 ◽  
Author(s):  
Jafar Soleymani ◽  
Mohammad Hasanzadeh ◽  
Nasrin shadjou ◽  
Mohammad Hossein Somi ◽  
Abolghasem Jouyban
Keyword(s):  
Cancer Cells ◽  
Analytical Approach ◽  
Folate Receptor

Role of Individual N-Linked Glycosylation Sites in the Function and Intracellular Transport of the Human α Folate Receptor

1998 ◽  
Vol 351 (2) ◽  
pp. 227-235 ◽  
Author(s):  
Susan J. Roberts ◽  
Maria Petropavlovskaja ◽  
Koong-Nah Chung ◽  
Clement B. Knight ◽  
Patrick C. Elwood
Keyword(s):  
Intracellular Transport ◽  
Folate Receptor ◽  
Glycosylation Sites

The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate

2009 ◽  
Vol 22 (5) ◽  
pp. 588-600 ◽  
Author(s):  
Luís Sánchez-del-Campo ◽  
María F. Montenegro ◽  
Juan Cabezas-Herrera ◽  
José Neptuno Rodríguez-López
Keyword(s):  
Folate Receptor ◽  
Critical Role

Role of the membrane-associated folate binding protein (folate receptor) in methotrexate transport by human KB cells

1989 ◽  
Vol 274 (2) ◽  
pp. 327-337 ◽  
Author(s):  
John C. Deutsch ◽  
Patrick C. Elwood ◽  
Raul M. Portillo ◽  
Michelle G. Macey ◽  
J.Fred Kolhouse
Keyword(s):  
Binding Protein ◽  
Folate Receptor ◽  
Kb Cells ◽  
Folate Binding Protein

The role of folate receptor autoantibodies in preterm birth

Nutrition ◽  
2015 ◽  
Vol 31 (10) ◽  
pp. 1224-1227 ◽  
Author(s):  
Hanh D. Vo ◽  
Jeffrey M. Sequeira ◽  
Edward V. Quadros ◽  
Steven M. Schwarz ◽  
Agnes R. Perenyi
Keyword(s):  
Preterm Birth ◽  
Folate Receptor
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