A cell-based system for hepatitis B virus replication: significance of clinically enhanced viral replication in relation to deletions in viral core promoter

10.2741/1674 ◽  
2005 ◽  
Vol 10 (1-3) ◽  
pp. 2001 ◽  
Author(s):  
Hong, Pan
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Virus Replication ◽  
Core Promoter ◽  
Viral Core ◽  
B Virus ◽  
A Cell

Presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss

2007 ◽  
Vol 39 (3) ◽  
pp. 199-204 ◽  
Author(s):  
R. Bridget Ferns ◽  
Nikolai V. Naoumov ◽  
Richard J. Gilson ◽  
Richard S. Tedder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Core Promoter ◽  
Virus Core ◽  
B Virus ◽  
Hbeag Loss ◽  
Promoter Mutations

scholarly journals X-gene Product Antagonizes the p53-mediated Inhibition of Hepatitis B Virus Replication through Regulation of the Pregenomic/Core Promoter

1995 ◽  
Vol 270 (52) ◽  
pp. 31405-31412 ◽  
Author(s):  
Hyunsook Lee ◽  
Young-Ho Lee ◽  
Yun-Sil Huh ◽  
Hongmo Moon ◽  
Yungdae Yun
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Product ◽  
Virus Replication ◽  
Core Promoter ◽  
B Virus ◽  
X Gene

scholarly journals Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus Carriers

1999 ◽  
Vol 179 (4) ◽  
pp. 775-782 ◽  
Author(s):  
Magnus Lindh ◽  
Charles Hannoun ◽  
Amar P. Dhillon ◽  
Gunnar Norkrans ◽  
Peter Horal
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Liver Damage ◽  
Core Promoter ◽  
East Asian ◽  
B Virus ◽  
Promoter Mutations

scholarly journals Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins

2006 ◽  
Vol 87 (7) ◽  
pp. 1883-1891 ◽  
Author(s):  
Sook-Young Sohn ◽  
Sun-Bum Kim ◽  
Joon Kim ◽  
Byung-Yoon Ahn
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Rna Binding ◽  
Core Protein ◽  
Ectopic Expression ◽  
Viral Core ◽  
Amino Terminal ◽  
B Virus ◽  
Carboxyl Terminal

The hepatitis B virus core protein consists of an amino-terminal capsid-assembly domain and a carboxyl-terminal RNA-binding domain. By using the yeast two-hybrid system, two Hsp40/DnaJ chaperone-family proteins, Hdj1 and hTid1, that interact with the carboxyl-terminal region (aa 94–185) of the core protein were identified. Hdj1 is the prototype member of the family and hTid1 is the human homologue of the Drosophila tumour-suppressor protein Tid56. Binding of the viral core protein with the Hsp40 proteins was confirmed by affinity chromatography and immunoprecipitation of transiently expressed proteins. Moreover, in a sucrose gradient, the precursor form of hTid1 co-sedimented with capsid-like particles composed of the full-length core protein. Unlike the general perception of the role of the cellular chaperone proteins in assisting viral protein folding and thus enhancing virus replication, ectopic expression of Hdj1 and hTid1 suppressed replication of HBV in transfected human hepatoma cells. Conversely, RNA interference-mediated knock-down of hTid1 resulted in increased HBV replication. It was found that both Hsp40 proteins specifically accelerated degradation of the viral core and HBx proteins. Our results suggest that the cellular chaperones, through destabilization of viral proteins, exert inhibitory functions on virus replication and hence may play suppressive roles in hepatocellular carcinoma.

scholarly journals Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

2021 ◽  
Author(s):  
Peter AC. Wing ◽  
Peter Jianrui Liu ◽  
James M. Harris ◽  
Andrea Magri ◽  
Thomas Michler ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Hypoxia Inducible Factors ◽  
B Virus
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