scholarly journals Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

10.2741/1535 ◽  
2005 ◽  
Vol 10 (1-3) ◽  
pp. 379 ◽  
Author(s):  
Cheng, Dong
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Flow Conditions ◽  
Dynamic Flow ◽  
Tumor Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions

Biochimie ◽  
2009 ◽  
Vol 91 (8) ◽  
pp. 1045-1052 ◽  
Author(s):  
Marcia R. Cominetti ◽  
Ana Carolina B.M. Martin ◽  
Juliana U. Ribeiro ◽  
Ibtissem Djaafri ◽  
Françoise Fauvel-Lafève ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Collagen I ◽  
Flow Conditions ◽  
Dynamic Flow ◽  
Tumor Cell Adhesion ◽  
Disintegrin Domain

scholarly journals Physical confinement alters tumor cell adhesion and migration phenotypes

2012 ◽  
Vol 26 (10) ◽  
pp. 4045-4056 ◽  
Author(s):  
Eric M. Balzer ◽  
Ziqiu Tong ◽  
Colin D. Paul ◽  
Wei‐Chien Hung ◽  
Kimberly M. Stroka ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration

2010 ◽  
Vol 127 (9) ◽  
pp. 1999-2008 ◽  
Author(s):  
Zhengwen An ◽  
Katalin Dobra ◽  
John G. Lock ◽  
Staffan Strömblad ◽  
Anders Hjerpe ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Malignant Mesothelioma ◽  
Tumor Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor

1999 ◽  
Vol 104 (9) ◽  
pp. 1213-1221 ◽  
Author(s):  
Edgar G. Fischer ◽  
Matthias Riewald ◽  
Hui-Yu Huang ◽  
Yohei Miyagi ◽  
Yoshinobu Kubota ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals Physical Biology in Cancer. 4. Physical cues guide tumor cell adhesion and migration

2014 ◽  
Vol 306 (2) ◽  
pp. C98-C109 ◽  
Author(s):  
Kimberly M. Stroka ◽  
Konstantinos Konstantopoulos
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Secondary Site ◽  
Tumor Cell Adhesion ◽  
Metastatic Cascade ◽  
Physical Cues ◽  
Cell Adhesion And Migration ◽  
And Migration

As tumor cells metastasize from the primary tumor location to a distant secondary site, they encounter an array of biologically and physically heterogeneous microenvironments. While it is well established that biochemical signals guide all stages of the metastatic cascade, mounting evidence indicates that physical cues also direct tumor cell behavior, including adhesion and migration phenotypes. Physical cues acting on tumor cells in vivo include extracellular matrix mechanical properties, dimensionality, and topography, as well as interstitial flow, hydrodynamic shear stresses, and local forces due to neighboring cells. State-of-the-art technologies have recently enabled us and other researchers to engineer cell microenvironments that mimic specific physical properties of the cellular milieu. Through integration of these engineering strategies, along with physics, molecular biology, and imaging techniques, we have acquired new insights into tumor cell adhesion and migration mechanisms. In this review, we focus on the extravasation and invasion stages of the metastatic cascade. We first discuss the physical role of the endothelium during tumor cell extravasation and invasion and how contractility of endothelial and tumor cells contributes to the ability of tumor cells to exit the vasculature. Next, we examine how matrix dimensionality and stiffness coregulate tumor cell adhesion and migration beyond the vasculature. Finally, we summarize how tumor cells translate and respond to physical cues through mechanotransduction. Because of the critical role of tumor cell mechanotransduction at various stages of the metastatic cascade, targeting signaling pathways involved in tumor cell mechanosensing of physical stimuli may prove to be an effective therapeutic strategy for cancer patients.

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

scholarly journals Specific Syndecan-1 Domains Regulate Mesenchymal Tumor Cell Adhesion, Motility and Migration

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e14816 ◽  
Author(s):  
Fang Zong ◽  
Eleni Fthenou ◽  
Filip Mundt ◽  
Tünde Szatmári ◽  
Ilona Kovalszky ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Mesenchymal Tumor ◽  
Tumor Cell Adhesion ◽  
And Migration

scholarly journals ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer

2020 ◽  
Author(s):  
Yu-Chen Cai ◽  
Hang Yang ◽  
Ke-Feng Wang ◽  
Tan-Huan Chen ◽  
Wen-Qi Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Tumor Cell Adhesion ◽  
Tumor Tissues ◽  
Cell Adhesion And Migration ◽  
And Migration

Abstract Background: Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with TNBC could help guide treatment. Extensive evidence demonstrates that angiopoietin-like 4 (ANGPTL4) is involved in the regulation of cancer growth, metastasis and angiogenesis. Therefore, its role in TNBC is of interest.Methods: We tested the ANGPTL4 expression level in tumor tissues by immunohistochemistry (IHC) and detected its association with the clinical features of TNBC patients. Next, the effects and mechanisms of ANGPTL4 on TNBC cell migration and adhesion were investigated.Results: We found that ANGPTL4 overexpression was associated with favorable outcomes in TNBC patients. ANGPTL4 upregulation inhibited cell adhesion, migration and invasion in vitro. Further analyses demonstrated that the possible mechanism might involve suppression of TNBC progression by interacting with extracellular matrix-related genes.Conclusions: The present findings demonstrated that enhancement of ANGPTL4 expression might inversely correlate with TNBC progression. ANGPTL4 is a promising marker of TNBC and should be evaluated in further studies. Trial registration: Retrospectively registered.

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