Structural characterization, photophysical and BSA binding interaction studies of 4,4'-bis(benzimidazolyl)-2,2'-bipyridine

2016 ◽  
Vol 57 (8) ◽  
pp. 1649
Author(s):  
K. Swarnalatha ◽  
P. Rathnamala ◽  
A.A. Babu ◽  
N. Bhuvanesh
Keyword(s):  
Crystal Structure ◽  
Bovine Serum Albumin ◽  
Structural Characterization ◽  
Photophysical Properties ◽  
Fluorescence Technique ◽  
Binding Interaction ◽  
X Ray ◽  
Bsa Binding ◽  
Interaction Studies ◽  
Ft Ir

The title compound is synthesized from the precursors 1,2-diaminobenzene and 2,2'-bipyridine-4,4'-dicarboxylic acid (dcbpy) and characterized using ESI-Mass, 1H NMR, FT-IR and single crystal X-ray analysis. We are the first to report the crystal structure of the 4,4'-bis(benzimidazolyl)-2,2'-bipyridine (bimbpy) ligand. The photophysical properties of the compound in dimethyl sulfoxide and in the aqueous medium are studied. The interaction studies of bimbpy with bovine serum albumin (BSA) were performed with the fluorescence technique and it strongly binds with BSA.

scholarly journals Molecular Docking and Extended Spectroscopy to Binding Characterizations: Etoposide a Glycoside of Podophyllotoxin with Bovine Serum Albumin

2021 ◽  
Vol 12 (1) ◽  
pp. 264-278
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Molecular Docking ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Discovery Process ◽  
Binding Interaction ◽  
Bsa Binding ◽  
Ft Ir

A significant soluble protein, specifically bovine serum albumin (BSA) plays an efficient role in drug delivery, and etoposide (ETS) is used to cure various cancers. Binding interaction between ETS and BSA examined by 3D, emission, synchronous fluorescence’s, UV–vis, FT–IR, and CD spectroscopy’s in the association of computational at pH 7.40 with 293, 301 and 309 K. Formed complex between ETS and BSA dominates van der Waals and bonding of hydrogen’s at sub-domain IIIA. Strong binding of ETS-BSA leads to altering BSA’s structural and conformations statically. Energy transfer reveals ETS-BSA distance. Apart from this, ETS-BSA binding is affected by Mg2+, Cu2+, Fe2+, Ca2+, and Co2+ ions. This study may help in the drug development and discovery process.

Structural Systematics of Rare Earth Complexes. VII. Crystal Structure of Bis(2,2'/6',2␛-Terpyridinium) Octaaquaterbium(III) Heptachloride Hydrate

1994 ◽  
Vol 47 (2) ◽  
pp. 391 ◽  
Author(s):  
CJ Kepert ◽  
BW Skeleton ◽  
AH White
Keyword(s):  
Crystal Structure ◽  
Rare Earth ◽  
Single Crystal ◽  
Structural Characterization ◽  
Title Compound ◽  
Room Temperature ◽  
Chloride Ions ◽  
Full Matrix ◽  
X Ray

The room-temperature single-crystal X-ray structural characterization of the title compound (tpyH2)2[Tb(OH2)8]Cl7.~2⅓H2O is recorded. Crystals are triclinic, Pī , a 17.063(5), b 16.243(3), c 7.878(3) Ǻ, α 84.78(2), β 84.39(3), γ 87.81(2)°, Z = 2 formula units; 3167 'observed' diffractometer reflections were refined by full-matrix least-squares procedures to a residual of 0.057. Notable features of interest of the compound are the 'chelation' of chloride ions by the terpyridinium cations , and the existence of a free [Tb(OH2)8]2+ cation in the presence of an abundance of chloride ions.

Nitroxide radicals appended to phthalonitriles: synthesis, structural characterization and photophysical properties

2021 ◽  
Vol 77 (3) ◽  
pp. 137-143
Author(s):  
Ismail Fidan ◽  
Emel Onal ◽  
Catherine Hirel
Keyword(s):  
Magnetic Measurements ◽  
Photophysical Properties ◽  
Nucleophilic Aromatic Substitution ◽  
Structural Studies ◽  
Aromatic Substitution ◽  
Nitronyl Nitroxide ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microwave Assisted ◽  
Ft Ir

The syntheses of 4-[4-(4,4,5,5-tetramethyl-2-imidazoline-3-oxide-1-oxyl-2-yl)phenoxy]phthalonitrile (3, C21H19N4O3) and 4-[4-(4,4,5,5-tetramethyl-2-imidazoline-1-oxyl-2-yl)phenoxy]phthalonitrile (4) were carried out by microwave-assisted nucleophilic aromatic substitution of 4-nitrophthalonitrile (2) by the pre-formed 2-(4-hydroxyphenyl)-4,4,5,5-tetramethyl-2-imidazoline-3-oxide-1-oxyl (1). Compounds 3 and 4 were characterized unambiguously by a rich array of analyses, such as melting point, FT–IR, MALDI–TOF MS, elemental analysis, UV–Vis, CV, EPR, magnetic measurements and single-crystal X-ray diffraction. Structural studies demonstrate that the C—H...X and C—X...π (X = O and N) interactions in the radical nitronyl nitroxide groups play an important role in the assembly of the crystal structures. Moreover, cyclic voltammetry analyses show that the phthalonitrile substituent retains the redox properties of the Ullman radicals.

A family of Ru(ii) complexes built on a novel sexipyridine building block: synthesis, photophysical properties and the rare structural characterization of a triruthenium species

2015 ◽  
Vol 44 (25) ◽  
pp. 11551-11561 ◽  
Author(s):  
Baptiste Laramée-Milette ◽  
Félix Lussier ◽  
Ilaria Ciofini ◽  
Garry S. Hanan
Keyword(s):  
Structural Characterization ◽  
Building Block ◽  
Photophysical Properties ◽  
X Ray

A new sexipyridine ligand and its Ru(ii) family of complexes is described along with its characterization by electrochemical and photophysical methods as well as a rare X-ray analysis of a triruthenium polypyridine complex.

Synthesis, Crystal Structure, Spectroscopic and Thermal Properties of a Novel Mixed Ligand Copper(II) Complex with 5,5-Dimethylhydantoin and Benzylamine

2006 ◽  
Vol 61 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Murat Taş ◽  
Serkan Soylu ◽  
Hümeyra Batı
Keyword(s):  
Crystal Structure ◽  
Thermal Analyses ◽  
Crystal Data ◽  
Monoclinic System ◽  
Magnetic Susceptibility Data ◽  
X Ray ◽  
Susceptibility Data ◽  
Ft Ir ◽  
Complex Features ◽  
Water Ligands

AbstractThe crystal structure of the newly synthesized complex, trans-aqua-bis(benzylamino)-bis(5,5-dimethylhydantoinato) copper(II) was determined by X-Ray single crystal data. The thermal analyses, FT-IR and magnetic susceptibility data are also presented. The complex crystallizes in the monoclinic system, space group C2. The complex features a distorted square pyramidal [CuN4O] coordination with 5,5-dimethylhydantoinato, benzylamine and water ligands. The 5,5-dimethylhydantoinato anion is bonded to the copper(II) ion via its deprotonated N atom in the 3-position.

Molecular and Crystal Structure of Two Cyclobuten-3,4-dione Derivatives: The Dithallium Salt of 1,2-Dicyanimino-(TI2CMCB) and the 1,2-Diiodocyclobuten-3,4-dione (I2CB)

1989 ◽  
Vol 44 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Bruno Lunelli ◽  
Magda Monari
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Crystal And Molecular Structure ◽  
Molecular And Crystal Structure ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calorimetric Measurements ◽  
Ft Ir

Abstract The crystal and molecular structure of the dithallium salt of the 1,2-dicyanim inocyclobuten-3,4-dione dianion and of 1,2-diiodocyclobuten-3,4-dione, determined by X-ray diffraction, are reported and discussed. Results of FT-IR and calorimetric measurements are also presented.

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