scholarly journals A Battery Powered on-Chip Peristaltic Pump for Lab-On-A-Chip Applications

2021 ◽  
Vol 5 (4) ◽  
pp. 201-205
Author(s):  
Sinan GÜÇLÜER
Keyword(s):  
Lab On A Chip ◽  
Peristaltic Pump ◽  
On Chip

scholarly journals 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
John-Alexander Preuss ◽  
Janina Bahnemann ◽  
Alexander Heisterkamp ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Cells ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Manipulation ◽  
Hydrodynamic Focusing ◽  
Trapping Region ◽  
Dual Beam ◽  
3D Printed ◽  
On Chip

Abstract3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

On-Chip Platinum Micro-Heater with Platinum Temperature Sensor for a Fully Integrated Disposable PCR Module

2010 ◽  
Vol 93-94 ◽  
pp. 129-132 ◽  
Author(s):  
W. Sripumkhai ◽  
A. Lekwichai ◽  
Win Bunjongpru ◽  
S. Porntheeraphat ◽  
B. Tunhoo ◽  
...  
Keyword(s):  
Thermal Cycling ◽  
Temperature Sensor ◽  
Lab On A Chip ◽  
Conventional Pcr ◽  
Fully Integrated ◽  
On Chip

The on-chip platinum micro-heater prototypes for thermal cycling equipped with platinum temperature sensor are fabricated. The device has been designed, fabricated and characterized to explore the feasibility of the micro-heater for a fully integrated disposable lab-on-a-chip with the PCR module. The on-chip micro-heater demonstrates that the temperature transitions are shorter by comparison with the conventional PCR temperature routines.

Size-tunable droplet microfluidic system using an on-chip microfluidic peristaltic pump

2021 ◽  
pp. 113332
Author(s):  
Tuo Ma ◽  
Yousu Wang ◽  
Shixin Sun ◽  
Tingrui Pan ◽  
Baoqing Li ◽  
...  
Keyword(s):  
Microfluidic System ◽  
Peristaltic Pump ◽  
On Chip

scholarly journals Miniaturization of fluorescence sensing in optofluidic devices

2020 ◽  
Vol 24 (9) ◽  
Author(s):  
Daniel Măriuţa ◽  
Stéphane Colin ◽  
Christine Barrot-Lattes ◽  
Stéphane Le Calvé ◽  
Jan G. Korvink ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Time Data ◽  
Fluorescence Sensing ◽  
Successful Development ◽  
Total Analysis System ◽  
Total Analysis ◽  
Integration Strategies ◽  
Analysis System ◽  
On Chip ◽  
Industrial Sensing

Abstract Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

scholarly journals Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump

Lab on a Chip ◽  
2017 ◽  
Vol 17 (22) ◽  
pp. 3796-3803 ◽  
Author(s):  
Jessica F. Liu ◽  
Sagar Yadavali ◽  
Andrew Tsourkas ◽  
David Issadore
Keyword(s):  
Small Volume ◽  
Peristaltic Pump ◽  
Chip Flow ◽  
Peristaltic Micropump ◽  
On Chip

A novel magnetically-driven peristaltic pump can be used to drive cyclic on-chip flow for small volume (50 μL) diafiltration.

scholarly journals Development of an automated on-chip bead-based ELISA platform

2015 ◽  
Vol 7 (19) ◽  
pp. 8472-8477 ◽  
Author(s):  
Jennifer Campbell ◽  
Nira R. Pollock ◽  
Andre Sharon ◽  
Alexis F. Sauer-Budge
Keyword(s):  
Immunosorbent Assay ◽  
Lab On A Chip ◽  
Enzyme Linked Immunosorbent Assay ◽  
Liquid Samples ◽  
On Chip

We present a lab-on-a-chip and associated instrument for heterogeneous enzyme-linked immunosorbent assay (ELISA)-based detection of proteins from liquid samples.

Development of an Automatic Electrokinetically-Controlled Microfluidic Immunoassay for the Detection of Helicobacter Pylori

2005 ◽  
Author(s):  
Yali Gao ◽  
Guoqing Hu ◽  
Frank Y. H. Lin ◽  
Philip M. Sherman ◽  
Dongqing Li
Keyword(s):  
Helicobacter Pylori ◽  
Detection Limit ◽  
Experimental Studies ◽  
Lab On A Chip ◽  
Protein Antigens ◽  
Immunoassay Technique ◽  
Microfluidic Immunoassay ◽  
Colorimetric Immunoassay ◽  
On Chip ◽  
H Pylori

A novel automatic electrokinetically-controlled immunoassay lab-on-a-chip was developed in this paper. The microchip was made of poly(dimethylsiloxane) (PDMS)/glass using photolithography and replica molding. The immunoassay technique using anti-Helicobacter pylori antibody was applied to detect H. pylori protein antigens. Rhodamine-labeled secondary antibody was employed for signal generation. Experiments were first conducted on a straight microchannel to prove the feasibility of an electrokinetically-driven immunoassay. The detection limit for the coating antigen was found to be 1 ng/μL. Automatic electrokinetically-controlled immunoassay experiments were further carried out on a microchannel network. Numerical simulation and experimental studies were combined for the first time to demonstrate an integrated, electrokinetically-controlled immunoassay lab-on-a-chip. The electrokinetically driven, time-dependent reagent delivery processes were simulated using finite element method (FEM). Fully automatic on-chip experiments were accomplished by sequentially changing the applied electric field. It was found that the lab-on-a-chip can realize much shorter assay time, reduced reagent consumptions and automation while the detection limit is better than the conventional colorimetric immunoassay.

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