Microbial Factor as a Participant of the Infectious Inflammatory Process in the Oral Cavity Pathology

2017 ◽  
Vol 2 (3) ◽  
pp. 12-15 ◽  
Author(s):  
E.V. Kotsar ◽  
◽  
O.I. Radchenko ◽  
O.V. Golubka ◽  
A.V. Masalova ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Inflammatory Process

scholarly journals Features of the course and treatment of chronic catarrhal gingivitis in dogs

2020 ◽  
Vol 22 (100) ◽  
pp. 71-77
Author(s):  
N. M. Khomyn ◽  
A. R. Mysak ◽  
S. V. Tsisinska ◽  
V. V. Pritsak ◽  
N. V. Nazaruk ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Mucous Membrane ◽  
Inflammatory Process ◽  
Recovery Period ◽  
Control Group ◽  
Treatment And Prevention ◽  
Before And After ◽  
Medicinal Substances ◽  
Effective Treatment Regimen

Periodontal disease is known to be the most common and serious health problem in dogs today. Despite the rather large arsenal of medicinal substances, the problem of treatment and prevention of periodontal disease remains relevant. Based on this, the purpose of the work was to study the features of chronic catarrhal gingivitis and to develop an effective treatment regimen for dentistically ill dogs. For research, two groups of animals with chronic catarrhal gingivitis were formed in 5 dogs in each (control and experimental), selected on the principle of analogues in terms of age, character and localization of the inflammatory process. Animals of the control and experimental groups were performed tartar removal, irrigation of the oral cavity with water and drying of the mucosa with a sterile gauze swab. Dogs of the control group on the mucous membrane was applied 1 ml of septogel 2 times a day, and the experimental – argumentistin 2 times a day. Before and after the procedures on the mucous membrane was applied a 3 % solution of hydrogen peroxide. It was determined the prevalence of dental disease in dogs, the influence of microflora on the condition of the oral cavity of dogs with chronic catarrhal gingivitis, the clinical condition and the main indices and samples were studied, reflecting the intensity of the inflammatory process in the gums of sick dogs and was developed a method of treatment. The results of researches have shown that the use of argumentistin in the complex treatment of dogs with chronic catarrhal gingivitis helps to reduce the recovery period by 5 days.

scholarly journals Features of the course and treatment of chronic catarrhal gingivitis in dogs

2019 ◽  
Vol 21 (96) ◽  
pp. 53-57
Author(s):  
N. M. Khomyn ◽  
A. R. Mysak ◽  
S. V. Tsisinska ◽  
V. V. Pritsak ◽  
N. V. Nazaruk ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Inflammatory Process ◽  
Recovery Period ◽  
Clinical Signs ◽  
Main Role ◽  
Dental Disease ◽  
Mineral Supplement ◽  
Clinical Indicators ◽  
Dental Plaques ◽  
Gel Composition

Chronic catarrhal gingivitis is a polyetiological disease, in the pathogenesis of which the main role belongs to the microorganisms of the oral cavity of the dog, odontogenic deposition in the form of dental plaques and tartar. These depositions, due to the constant irritation of the gums cause disease, the main clinical signs of which are halitosis, poor feed intake, swelling and bleeding gums. The problem of chronic catarrhal gingivitis treatment is devoted to numerous inverstigations, the priority of which is a comprehensive approach, which includes a step-by-step influence on the etiological and pathogenetic mechanisms of the disease. Therefore, the purpose of the work is to study the features of the course of chronic catarrhal gingivitis and to develop a method for the treatment of dogs with dental disease. The prevalence gingivitis in dogs, the influence of microflora on the condition of the oral cavity in chronic catarrhal gingivitis, was investigated the symptomatology of the disease, was established the value of clinical indicators and dental indices and tests, which reflect the intensity and nature of the inflammatory process in the gums of dogs suffering from chronic catarrhal gingivitis, and a method of treating dental animals was developed. The results of the inverstigations showed that the application by application to the mucous membrane of gums 0.05% solution of chlorhexidine  and a gel composition of 4% chitosan ascorbate with metronidazole, and also feeding once a day for 30 days of the vitamin-mineral supplement “Canvit Biocal Plus” in the complex treatment of dogs with chronic catarrhal gingivitis helps to reduce the recovery period of dogs by 5 days.

scholarly journals ASSESSMENT OF THE DENTAL STATUS OF PREGNANT WOMEN

2020 ◽  
Vol 75 (3) ◽  
pp. 166-169 ◽  
Author(s):  
S.V. Miklyaev ◽  
◽  
I.A. Miklyaeva ◽  
◽  
◽  
...  
Keyword(s):  
Oral Cavity ◽  
Pregnant Women ◽  
Oral Hygiene ◽  
Inflammatory Process ◽  
Dental Status ◽  
Dental Office ◽  
Unborn Baby ◽  
Duration Of Pregnancy

A survey of 86 pregnant women was conducted in order to study the hygienic state of the oral cavity at different stages of pregnancy. It was found that 62 (72,09 %) of pregnant women were motivated to visit the dental office to maintain their own health and the health of the unborn baby, 20 women (23,25 %) were concerned about the safety of their own dental system, 4 women (4,65 %) did not understand the need to visit a dentist. The dental status of pregnant women was assessed based on dental indices: OHI-S, CPITN, PMA, and the H. R. Muhleman gum bleeding index. The dependence of the level of oral hygiene on the duration of pregnancy was revealed, at the same time, the severity of the inflammatory process did not depend on the trimester.

Częstość występowania i różnorodność patologicznych zmian w jamie ustnej u pacjentów leczonych w Zakładzie Chirurgii Stomatologicznej WUM w latach 2012–2017. Badanie retrospektywne

2020 ◽  
Vol 8 (4) ◽  
pp. 93-101
Author(s):  
Konrad Wojtasiński ◽  
Agata Borsukiewicz ◽  
Krzysztof Szcześniak ◽  
Martyna Osiak ◽  
Andrzej Wojtowicz
Keyword(s):  
Oral Cavity ◽  
Inflammatory Process ◽  
Reliable Method ◽  
Malignant Tumors ◽  
Final Diagnosis ◽  
Conservative Approach ◽  
Pathological Changes ◽  
Dental Surgery ◽  
Neoplastic Lesions ◽  
Medical University

Introduction A large number of lesions of various etiopathogenesis may be found in the oral cavity. They range from benign inflammatory-hyperplastic changes to malignant tumors. The following study aims to statistically show the frequency and type of changes depending on the age and sex of patients treated in the Department of Dental Surgery of the Medical University of Warsaw. Material and methods 612 results of histopathological examinations of sections or entire lesions of the oral cavity collected from patients in the years 2012–2017 were analyzed. The results were analyzed in terms of gender, age and the site of tissue collection. Neoplasms and 8 other groups of lesions of the mucosa were distinguished. Results The most common lesion was fibroma (35%), followed by a chronic inflammatory process (15.4%), and salivary gland cysts (11.9%). Papillomas (HPV) accounted for 10.5%, epilemomas 9.64%, tumors 6.54%, cysts and ulcers 4.74% and 4.25%, respectively. Pre-neoplastic lesions were found in 70 cases. These included ulcerations, leukoplakia, changes with metaplasia, dysplasia and pseudo-neoplastic hyperplasia. The most common localization of pathological changes in the oral cavity was related to the gums. Conclusions Many lesions of various etiology may present with a similar clinical manifestation. Therefore, in order to correctly diagnose pathological changes in the oral cavity, it is necessary to conduct a thorough medical history and physical examination, and identify the factors that may have caused the lesion. A particular group of pathological changes of the oral mucosa are ulcers which, despite a conservative approach, do not respond to treatment. In such cases a neoplasm should be suspected and a section of the lesion be obtained for histopathological evaluation which is the only reliable method that allows a final diagnosis.

scholarly journals AN INFLUENCE OF INFLAMMATORY DISEASES OF GASTROINTESTINAL TRACT ON PARODONTIUM IN CHILDREN

2019 ◽  
Vol 19 (4) ◽  
pp. 118-122
Author(s):  
S.S. Bauman ◽  
O.V. Sheshukova
Keyword(s):  
Transcription Factors ◽  
Gastrointestinal Tract ◽  
Oral Cavity ◽  
Inflammatory Mediators ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Nuclear Factor ◽  
Periodontal Tissues ◽  
Transcription Activators ◽  
Main Factor

Diseases of gastrointestinal tract refer to the most widespread patholigical conditions of infancy and constant 25,5-31,3% from general mirbidity. Inflammatory diseases of gastrointestinal tract are often accompined with damage of dentofacial system. Oral cavity is the first element of gastrointestinal tract, so even the smallest changes can have manifestations on oral mucosa, periodontal tissues, teeth of children. Microflora in oral cavity and endogenic and pathogenic factors can give an opportunity to define dental diseases in children with diseases of gastrointestinal tract to diseases of systemic factors of etiology and pathogenesis. The aim is to analyze data about correction between oral cavity disorders with diseases of different regions of gastrointestinal tract in order to determine further developments of possible preventive measures, which will prevent the development of damage. The problem of periodontal tissues in children is one of the main issue for modern dentistry. Scientific investigations proved that initial changes during catarrhal gingivitis without timely treatment causes severe forms of parodontitis. Low level of oral hygiene is the main factor of plaque formation, which has high potential for pathogenic factor and it can seen as the main factor of inflammatory process of periodontal tissues. Transcription factors are factors present in cytoplasm of main cells and during activation they are transported in the nucleus to regulate the manufacturing of Inflammatory mediators. However, there are a lot of Information about inflammatory mediators of periodontal tissues damage, but nowadays the role of transcription factors has not studied yet. Nuclear factor-kappa B(NF-kB) and signal arrangaments and transcription activators 3(STAT3) are two main factors of transcription, involved in chronic Inflammatory diseases. But their significance in periodontal tissues, pathogenesis has not studied. Researches proved, that cytokines are trigger of inflammatory process in periodontal tissues and precusors of patholigical changes. Cytokines are primary line of activation of immune response, determine the efficacy and type of immune reaction on infectious and non-infectious agents, regulate inflammatory immune reactions. Having analyzed different scientific sources, it has been defined, that nuclear factor of transcription NF-kB and its manifestations during periodontal tissues inflammation in children has not practically studied. 

scholarly journals THE CONTENT OF INTERLEUKINS IN ORAL FLUID OF PATIENTS WITH NON-REMOVABLE METAL CERAMIC PROSTHESES

2018 ◽  
pp. 27-31
Author(s):  
Yu. M. Hotsko ◽  
L. Ye. Lapovets
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Inflammatory Process ◽  
Oral Fluid ◽  
Protective Mechanism ◽  
Dental Prostheses ◽  
Tnf Α ◽  
Metal Ceramic ◽  
Anti Inflammatory ◽  
High Level

The dental bridges are often used to replace missing teeth. Currently, the most common are the metal-ceramic structures, which have the high mechanical properties and are aesthetic and functional, because they restore chewing efficiency by 85-100% and provide a high level of adaptation to them. However, in the presence of metallic and combined prostheses in the oral cavity, the pathological changes may occur, taking into account that in the oral cavity, the non-removable dentures are foriegn bodies affecting the tissues and the environment of the oral cavity. The effect of almost all artificial bridges on the tissues of the marginal periodontal disease depends on the level of the location of the bridge margin and the depth of the immersion under the gum. In the presence of such processes, the main factor is the specific antimicrobial protection, which is carried out by immunoglobulins; in the oral cavity, there are present only IgA, IgG, IgM of six classes. Thus, in the prosthetic dentistry one of the important problems is the connection of prosthetic constructions and the state of the oral cavity – homeostasis. The dental prostheses activate the lipid peroxidation and reduce the antioxidant defense factors. On the 7th day after bridge fixation, there is a significant decrease in the level of antioxidant enzymes and immunoglobulins and high concentrations of anti-inflammatory cytokines and interleukins. It is found that on the first stage of dental prosthesis the activity of lysozyme is sharply reduced and then restored very slowly. There is reduced not only non-specific reactivity (lysozyme), but also specific (lgA, IgG, and IgE) affected by dental prostheses, in particular, from acrylic plastics. The clinical data of 46 patients, age between 29 – 73 years old (56% of women, 44% of men), which had the non-removable metal ceramic crowns and bridge prostheses, and the indicators of immune markers in the oral fluid were used. In a determination of IL-1β concentration in the saliva of the tested patients, there was found a significant increase by a factor of 12 in the control parameters, it indicates on the high activity of the monocyte-macrophage lineage cells. In the saliva, the increased content of IL-1β confirms its role in the local inflammatory process and indicates the activation of endothelial cells and connective tissue. In the group of patients, IL-6 salivary content exceeds the level in healthy people by 3.66 times, indicating a protective mechanism that is necessary for the initial phase of inflammation. The IL-6 high level is a prognostic adverse factor, which can indicate the progression of the inflammatory process and the increase of membrane-destructive disorders in the cells. Monocytes and macrophages, activated by periodontopathogenic microbes, produce all cascade of proinflammatory interleukins, causing an imbalance between them. The damage of the periodontal tissue and resorption of the alveolar bone occur. In periodontal disease, the most damaging effect is characteristic for IL-1β and TNF-α. In the saliva of patients, there was detected an increased TNF-α level by 2.89 times compared to control, that has a negative inotropic effect, stimulates apoptosis, and increases vascular wall permeability. In prolonged prosthesis in the saliva of patients, there was found the higher level of IL-4 than in healthy individuals by 1.24 times. IL-4 is an anti-inflammatory cytokine, an activator and chemokinetic factor for phagocytes. The cytokines ensure the consistency and completeness of the immune response. Most of them induce inflammatory reaction and acute phase response of the organism and can exhibit the immunopathological effect on the tissues. At the systemic level, cytokines modulate the key protective reactions of the organism.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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