scholarly journals Proximate composition, minerals contents, functional properties of Mastura variety jackfruit (Artocarpus heterophyllus) seeds and lethal effects of its crude extract on zebrafish (Danio rerio) embryos

Food Research ◽  
2019 ◽  
Vol 3 (5) ◽  
pp. 546-555 ◽  
Author(s):  
S.F. Sy Mohamad ◽  
F. Mohd Said ◽  
M.S. Abdul Munaim ◽  
S. Mohamad ◽  
W.M.A. Wan Sulaiman
Keyword(s):  
Functional Properties ◽  
Danio Rerio ◽  
Crude Extract ◽  
Proximate Composition ◽  
Lethal Effects ◽  
Artocarpus Heterophyllus ◽  
Danio Rerio Embryos

scholarly journals Toxicity and teratogenicity evaluation of hydroethanolic extract of momordica charantia fruit using zebrafish (DANIO RERIO) embryos model

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
Noor Izati Abd Aziz ◽  
Vikneswari Perumal ◽  
Suganya Murugesu ◽  
Qamar Uddin Ahmed ◽  
Bisha Fathamah Uzir ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Crude Extract ◽  
Momordica Charantia ◽  
Spinal Curvature ◽  
Zebrafish Embryos ◽  
Chemical Toxicity ◽  
Active Constituent ◽  
Hydroethanolic Extract ◽  
Danio Rerio Embryos

 The use of zebrafish vertebrate model in vivo analysis of the drug toxicity and efficacy, chemical toxicity, and safety is increasing in recent researches. Momordica charantia Linn (Cucurbitaceae) has been traditionally claimed for its many protective roles. However, the development of toxicity effect may cause morphological abnormalities by using an embryo of zebrafish (Danio Rerio) is unknown. Hence, this study was designed to determine the toxicity and teratogenic effect of hydroethanolic extract of M. charantia fruit using Zebrafish (Danio Rerio) embryos. The crude extract was prepared from the fruit of M. charantia using 80% hydroethanolic solvent. The zebrafish embryos were exposed to serial dilution of crude extract. The active constituent was analyzed using gas chromatography coupled with mass spectrophotometry (GC-MS) Momordica charantia Linn (Cucurbitaceae) has been widely commercialized based on traditional usage as an antidiabetic product. The current study has shown the toxic effects of the M.  charantia fruit extract on the developing zebrafish embryos, and the median lethal concentration (LC50) was calculated to be 725.90 mg/L at 48 hpt. The observed effects are dependent on the time of exposure and concentrations of the extract. At higher concentration, the extract causes some morphological defects such as less pigmentation, dented tail, spinal curvature, oedema, reduced hatchability, and growth retardation, that indicates the presence of toxicant(s). Based on the GC-MS profiling, some of the compounds identified in the hydroethanolic extract, such as propanedioic acid and glutamine, may have caused the teratogenic effects to the embryos. Further research on the M. charantia fruit's metabolites should be carried out prior to any nutraceutical or pharmaceutical application.

Investigation into the sub‐lethal effects of the triazole fungicide triticonazole in zebrafish ( Danio rerio ) embryos/larvae

2019 ◽  
Vol 35 (2) ◽  
pp. 254-267 ◽  
Author(s):  
Christopher L. Souders ◽  
Veronica Perez‐Rodriguez ◽  
Nader El Ahmadie ◽  
Xujia Zhang ◽  
Claire Tischuk ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Lethal Effects ◽  
Triazole Fungicide ◽  
Danio Rerio Embryos

scholarly journals Lethal and Sub-Lethal Effects and Modulation of Gene Expression Induced by T Kinase Inhibitors in Zebrafish (Danio Rerio) Embryos

Toxics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 4
Author(s):  
Tina Elersek ◽  
Matjaž Novak ◽  
Mateja Mlinar ◽  
Igor Virant ◽  
Nika Bahor ◽  
...  
Keyword(s):  
Imatinib Mesylate ◽  
Danio Rerio ◽  
Kinase Inhibitors ◽  
Lethal Effects ◽  
Expression Of Genes ◽  
Embryo Toxicity Test ◽  
Damage Response ◽  
Embryo Toxicity ◽  
Modulation Of Gene Expression ◽  
Danio Rerio Embryos

Tyrosine kinase inhibitors (TKIs) are designed for targeted cancer therapy. The consumption of these drugs during the last 20 years has been constantly rising. In the zebrafish (Danio rerio) embryo toxicity test, we assessed the toxicity of six TKIs: imatinib mesylate, erlotinib, nilotinib, dasatinib, sorafenib and regorafenib. Imatinib mesylate and dasatinib induced lethal effects, while regorafenib, sorfenib and dasatinib caused a significant increase of sub-lethal effects, predominantly oedema, no blood circulation and formation of blood aggregates. The analyses of the changes in the expression of selected genes associated with the hormone system after the exposure to imatinib mesylate, dasatinib and regorafenib demonstrated that all three tested TKIs deregulated the expression of oestrogen receptor esr1, cytochrome P450 aromatase (cypa19b) and hydroxysteroid-dehydrogenase (hsd3b), regorafenib, and also thyroglobulin (tg). The expression of genes involved in the DNA damage response (gadd45 and mcm6) and apoptosis (bcl2) was deregulated only by exposure to regorafenib. The data indicate that common mechanisms, namely antiangiogenic activity and interference with steroidogenesis are involved in the TKI induced sub-lethal effects and potential hormone disrupting activity, respectively. The residues of TKIs may represent an environmental hazard; therefore, further ecotoxicological studies focusing also on the effects of their mixtures are warranted.

Neurulation in the posterior region of zebrafish, Danio rerio embryos

2021 ◽  
Author(s):  
Julia Gladysheva ◽  
Evdokia Evnukova ◽  
Ekaterina Kondakova ◽  
Milana Kulakova ◽  
Vladimir Efremov
Keyword(s):  
Danio Rerio ◽  
Posterior Region ◽  
Danio Rerio Embryos

scholarly journals Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos

Chemosphere ◽  
2021 ◽  
Vol 276 ◽  
pp. 130282
Author(s):  
Johannes Pohl ◽  
Oksana Golovko ◽  
Gunnar Carlsson ◽  
Stefan Örn ◽  
Monika Schmitz ◽  
...  
Keyword(s):  
Network Analysis ◽  
Danio Rerio ◽  
Danio Rerio Embryos

91. Studies on impact of chilling on sox gene expression in zebrafish (Danio rerio) embryos

Cryobiology ◽  
2010 ◽  
Vol 61 (3) ◽  
pp. 389
Author(s):  
K.K. Desai ◽  
E. Spikings ◽  
D.M. Rawson ◽  
T. Zhang
Keyword(s):  
Gene Expression ◽  
Danio Rerio ◽  
Sox Gene ◽  
Danio Rerio Embryos

Short exposure to glyphosate induces locomotor, craniofacial, and bone disorders in zebrafish (Danio rerio) embryos

2021 ◽  
pp. 103700
Author(s):  
Rubén D. Díaz-Martín ◽  
Ana Carvajal-Peraza ◽  
Beatriz Yáñez-Rivera ◽  
Miguel Betancourt-Lozano
Keyword(s):  
Danio Rerio ◽  
Short Exposure ◽  
Bone Disorders ◽  
Danio Rerio Embryos

Effects of the brominated flame retardant, TBCO, on development of zebrafish (Danio rerio) embryos

Chemosphere ◽  
2021 ◽  
Vol 266 ◽  
pp. 129195
Author(s):  
Darren Van Essen ◽  
Chloe Devoy ◽  
Justin Miller ◽  
Paul D. Jones ◽  
Steve Wiseman
Keyword(s):  
Flame Retardant ◽  
Danio Rerio ◽  
Brominated Flame Retardant ◽  
Danio Rerio Embryos

Lethal effects of abamectin on the aquatic organisms Daphnia similis, Chironomus xanthus and Danio rerio

Chemosphere ◽  
2012 ◽  
Vol 86 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Andréa Novelli ◽  
Bruna Horvath Vieira ◽  
Daniela Cordeiro ◽  
Luciana Teresa Dias Cappelini ◽  
Eny Maria Vieira ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Aquatic Organisms ◽  
Lethal Effects ◽  
Daphnia Similis
Sign in / Sign up

Export Citation Format

Share Document