A study of etiology, risk factors of non-traumatic small intestinal perforation

2020 ◽  
Vol 17 (1) ◽  
pp. 01-04
Author(s):  
Chamandeep Baljit Singh Kamboj ◽  
Keyword(s):  
Risk Factors ◽  
Intestinal Perforation ◽  
Small Intestinal

Small Intestinal Bacterial Overgrowth Is Associated with Non- Alcoholic Fatty Liver Disease

2016 ◽  
Vol 25 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Andrea Fialho ◽  
Andre Fialho ◽  
Prashanthi Thota ◽  
Arthur J. McCullough ◽  
Bo Shen
Keyword(s):  
Risk Factors ◽  
Fatty Liver Disease ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Study Group ◽  
Alcoholic Fatty Liver ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal ◽  
Alcoholic Fatty Liver Disease

Background: Changes in gut bacteria play a role in type 2 diabetes mellitus (DM) and hepatic steatosis. There is a lack of studies evaluating the frequency and risk factors for non-alcoholic fatty liver disease (NAFLD) in patients tested for small intestinal bacterial overgrowth (SIBO). Aim: To evaluate the frequency of NAFLD and associated risk factors in patients tested for SIBO. Methods: In this case-control study, 372 eligible patients submitted to glucose hydrogen/methane breath test for SIBO who also had an abdominal imaging study were included. Patients were divided into SIBO-positive and SIBO-negative groups. Clinical, demographic and laboratory variables were evaluated in addition to the presence of NAFLD on abdominal imaging. Results: Of the 372 eligible patients, 141 (37.9%) were tested positive for SIBO (study group) and 231 (62.1%) were negative for it (control group). NAFLD occurred in 45.4% (64/141) of the study group compared to 17.3% (40/231) of the control group (p<0.001). Patients in the study group were found to have higher rates of elevated aspartate aminotransferase (AST) (20.6% vs. 11.3%; p=0.034) and alanine aminotransferase (ALT) levels (56.0% vs. 40.7%; p= 0.039), type 2 diabetes (23.4% vs. 13.9%; p=0.041), hypertension (54.6% vs. 40.3%; p=0.046) and metabolic syndrome (78.0% vs. 60.2%; p=0.020). In the multivariate analysis, SIBO (odds ratio [OR]: 1.95; 95% confidence interval [CI]: 1.14-3.31; p=0.014), type 2 DM (OR: 3.04; 95%CI: 1.57-5.90; p=0.001) and obesity (OR: 3.58; 95%CI: 1.70-7.54; p=0.001) remained associated with NAFLD.Conclusion: Patients with SIBO have an increased risk for hepatic steatosis and may benefit from aggressive control of the risk factors for NAFLD including metabolic syndrome. Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CTE: computed tomography enterography; DM: diabetes mellitus; ETOH: ethanol; IL: interleukin; LPS: lipopolysaccharide; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; PPI: proton pump inhibitor; SIBO: small intestinal bacterial overgrowth; TLR-4: toll-like receptor 4; TMAO: trimethylamine-N-oxide (TMAO); TNF-α: tumor necrosis factor alpha.

Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin

2021 ◽  
Author(s):  
Tamara I. Arnautovic ◽  
Jami L. Longo ◽  
Elizabeth J. Trail-Burns ◽  
Richard Tucker ◽  
Martin Keszler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Intestinal Perforation ◽  
Factors Associated ◽  
Spontaneous Intestinal Perforation

scholarly journals Risk factors of symptomatic NSAID-induced small intestinal injury and diaphragm disease

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
M. Ishihara ◽  
N. Ohmiya ◽  
M. Nakamura ◽  
K. Funasaka ◽  
R. Miyahara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intestinal Injury ◽  
Diaphragm Disease ◽  
Small Intestinal Injury ◽  
Small Intestinal

Prevalence of and Risk Factors for Postoperative Ileus after Small Intestinal Surgery in Two Hundred and Thirty-Three Horses

2009 ◽  
Vol 38 (3) ◽  
pp. 368-372 ◽  
Author(s):  
SUSAN J. HOLCOMBE ◽  
KATIE M. RODRIGUEZ ◽  
JENNIFER L. HAUPT ◽  
JAMES O. CAMPBELL ◽  
KRISTIN P. CHANEY ◽  
...  
Keyword(s):  
Risk Factors ◽  
Postoperative Ileus ◽  
Intestinal Surgery ◽  
Small Intestinal
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