scholarly journals Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor like features and metaplastic bone formation

2020 ◽  
Vol 13 (2) ◽  
pp. 107-109
Author(s):  
Hena S odha ◽  
◽  
Meena Daveshwar ◽  
Pankti Macwan ◽  
Kinjal Patel ◽  
...  
Keyword(s):  
Bone Formation ◽  
Inflammatory Myofibroblastic Tumor ◽  
Dedifferentiated Liposarcoma ◽  
Metaplastic Bone

Dedifferentiated Liposarcoma With Meningothelial-Like Whorls: Five Additional Cases and Review of the Literature

2020 ◽  
Vol 28 (7) ◽  
pp. 749-758
Author(s):  
Muhammad Usman Tariq ◽  
Naila Kayani ◽  
Tariq Moatter ◽  
Nasir Ud Din
Keyword(s):  
Bone Formation ◽  
Gene Amplification ◽  
Early Stage ◽  
Smooth Muscle Actin ◽  
Follicular Dendritic Cell ◽  
Dedifferentiated Liposarcoma ◽  
Hybridization Technique ◽  
Mdm2 Gene ◽  
Metaplastic Bone ◽  
Immunohistochemical Stains

Background. Diagnosis of dedifferentiated liposarcoma (DDL) can sometimes be challenging due to a wide variety of histological features. “Meningothelial-like” whorl is an uncommon histological feature of DDL, which is also observed in neural tumors and follicular dendritic cell sarcoma. This feature is frequently associated with metaplastic bone formation. We conducted this study to describe the clinicopathological features of DDL with meningothelial-like whorls that would aid in establishing accurate diagnosis. Material and Methods. Microscopic glass slides of 5 cases of DDL with meningothelial-like whorls, diagnosed between January 2010 and December 2019, were reviewed. Results. Paratesticular region was the most common site. Whorls occupied 10% to 75% of tumor area and ranged in size from <0.1 cm to >2 cm. In 1 case, these whorls coalesced to form large areas of dedifferentiation. The cells forming whorls were spindle to epithelioid shaped and lacked significant nuclear pleomorphism and increased mitoses. Metaplastic bone formation was observed in 4 cases and cartilage formation in 3 cases. p16 and α-smooth muscle actin (α-SMA) immunohistochemical stains were positive in 2 cases, when performed. MDM2 gene amplification was observed in all cases by fluorescence in situ hybridization technique. These tumors showed aggressive behavior, similar to that of DDL without meningothelial-like whorls. Two patients died, 1 developed recurrence, 1 presented as recurrent tumor, and 1 developed metastasis. Conclusion. Meningothelial-like whorls in DDL most likely represent an early stage of dedifferentiation. Presence of well-differentiated liposarcoma areas, metaplastic bone formation, positive expressions for p16 and α-SMA immunohistochemical stains, and MDM2 gene amplification are useful diagnostic clues. These tumors have the potential to behave aggressively.

Cytogenetic and molecular genetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation

2006 ◽  
Vol 171 (2) ◽  
pp. 126-129
Author(s):  
Ricardo S. Macarenco ◽  
Michele Erickson-Johnson ◽  
Xiaoke Wang ◽  
Robert B. Jenkins ◽  
Antonio G. Nascimento ◽  
...  
Keyword(s):  
Bone Formation ◽  
Molecular Genetic ◽  
Dedifferentiated Liposarcoma ◽  
Metaplastic Bone

scholarly journals PRIMARY DEDIFFERENTIATED LIPOSARCOMA WITH METAPLASTIC BONE FORMATION

2004 ◽  
Vol 65 (7) ◽  
pp. 1966-1969 ◽  
Author(s):  
Takahiro HIRATSUKA ◽  
Takashi NISHIZAKI ◽  
Shinji YAMAMURA ◽  
Yasutomo OJIMA ◽  
Yoshihisa SAKAGUCHI ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dedifferentiated Liposarcoma ◽  
Metaplastic Bone

Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation

2005 ◽  
Vol 46 (5) ◽  
pp. 594-596 ◽  
Author(s):  
T Matsumoto ◽  
M Fukunaga ◽  
H Fujii ◽  
A Arakawa ◽  
S Yamasaki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dedifferentiated Liposarcoma ◽  
Metaplastic Bone

Dedifferentiated liposarcoma with peculiar meningothelial-like whorling and metaplastic bone formation

2009 ◽  
Vol 13 (4) ◽  
pp. 278-284 ◽  
Author(s):  
Joon Seon Song ◽  
Jerad M. Gardner ◽  
William P. Tarrant ◽  
Steven Shen ◽  
Alberto G. Ayala ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dedifferentiated Liposarcoma ◽  
Metaplastic Bone

Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation

2007 ◽  
Vol 172 (2) ◽  
pp. 147-150 ◽  
Author(s):  
Ricardo S. Macarenco ◽  
Michele Erickson-Johnson ◽  
Xiaoke Wang ◽  
Robert B. Jenkins ◽  
Antonio G. Nascimento ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dedifferentiated Liposarcoma ◽  
Molecular Cytogenetic ◽  
Metaplastic Bone

scholarly journals METAPLASTIC BONE FORMATION IN THE LUNG

1973 ◽  
Vol 118 (2) ◽  
pp. 344-346 ◽  
Author(s):  
ALAN N. JACOBS ◽  
HAROLD R. NEITZSCHMAN ◽  
CHARLES M. NICE
Keyword(s):  
Bone Formation ◽  
Metaplastic Bone

scholarly journals RENAL CELL CARCINOMA WITH OSSEOUS METAPLASIA OCCURRING IN A CONTRACTED KIDNEY - A RARE CASE REPORT

2013 ◽  
Vol 03 (04) ◽  
pp. 137-138
Author(s):  
Harish S. Permi
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Bone Formation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Good Prognosis ◽  
Osseous Metaplasia ◽  
Tumor Spread ◽  
Metaplastic Bone

AbstractOsseous metaplasia is a rare histologic feature associated with renal cell carcinoma, occurring in a contracted kidney is still rarer. Metaplastic bone formation within the renal tumor gives an appearance similar to that of calcification. It is difficult to distinguish between bone formation and calcification on the basis of radiological imaging alone. Prognostic significance of metaplastic bone formation in renal cell carcinoma is not clear, however some report suggest good prognosis as a result of limitation of tumor spread by bone formation. This case report highlights the occurrence of renal cell carcinoma with osseous metaplasia in a contracted kidney.

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