Colorectal carcinomas - Role of p53

2019 ◽  
Vol 11 (3) ◽  
pp. 144-149
Author(s):  
Sindu V ◽  
◽  
Priyadharshini M ◽  
Keyword(s):  
Colorectal Carcinomas

scholarly journals The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207227 ◽  
Author(s):  
Evangelos Koustas ◽  
Athanasios G. Papavassiliou ◽  
Michalis V. Karamouzis
Keyword(s):  
Microsatellite Instability ◽  
Colorectal Carcinomas ◽  
Braf Mutant

scholarly journals Role of Serial Plasma C.E.A. Assays in Detection of Recurrent and Metastatic Colorectal Carcinomas

BMJ ◽  
1974 ◽  
Vol 4 (5941) ◽  
pp. 382-385 ◽  
Author(s):  
A. M. Mackay ◽  
S. Patel ◽  
S. Carter ◽  
U. Stevens ◽  
D. J. R. Laurence ◽  
...  
Keyword(s):  
Colorectal Carcinomas

The Role of hMLH1 Methylation in the Development of Synchronous Sporadic Colorectal Carcinomas

2002 ◽  
Vol 45 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Mark W. A. Norrie ◽  
Nicholas J. Hawkins ◽  
Alison V. Todd ◽  
Alan P. Meagher ◽  
Terence W. OʼConnor ◽  
...  
Keyword(s):  
Colorectal Carcinomas

scholarly journals Upgraded role of autophagy in colorectal carcinomas

2018 ◽  
Vol 10 (11) ◽  
pp. 367-369 ◽  
Author(s):  
Evangelos Koustas ◽  
Panagiotis Sarantis ◽  
Athanassios G Papavassiliou ◽  
Michalis V Karamouzis
Keyword(s):  
Colorectal Carcinomas

The Potential Role of TGFβ1, TGFβ2 and TGFβ3 Protein Expression in Colorectal Carcinomas

2004 ◽  
Vol 180 (4) ◽  
pp. 201-208 ◽  
Author(s):  
Athanassios C. Tsamandas ◽  
Dimitrios Kardamakis ◽  
Panagiota Ravazoula ◽  
Vassiliki Zolota ◽  
Stavroula Salakou ◽  
...  
Keyword(s):  
Protein Expression ◽  
Potential Role ◽  
Colorectal Carcinomas

scholarly journals Human Colorectal Carcinoma Infiltrating B Lymphocytes Are Active Secretors of the Immunoglobulin Isotypes A, G, and M

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 776 ◽  
Author(s):  
Christina Susanne Mullins ◽  
Michael Gock ◽  
Mathias Krohn ◽  
Michael Linnebacher
Keyword(s):  
Mhc Class Ii ◽  
Functional Role ◽  
Ex Vivo ◽  
Tumor Control ◽  
Colorectal Carcinomas ◽  
Histocompatibility Complex ◽  
Immunoglobulin Isotypes ◽  
Human Colorectal Carcinoma ◽  
Tumor Entities

Despite the importance of tumor infiltrating B cells (TiBc) in immunological circuits, their functional role is scarcely investigated. Here, we analyzed immunoglobulin (Ig) secretion of the subtypes IgA, IgG, and IgM of TiBc from freshly resected primary and secondary colorectal carcinomas (CRC) by FluoroSpot (n = 30 CRC) directly ex vivo. High, intermediate, and low secretion was observed in 33%, 37%, and 30% of the tumors for IgA; in 10%, 27%, and 63% for IgG; and in 21%, 36%, and 50% for IgM, respectively. These ex vivo data validate our previous findings: Most TiBc present in the CRC microenvironment are functional since they produce and actively secrete Ig (IgA > IgG > IgM). Of note, the presence of major histocompatibility complex (MHC) class II expressing cells in the tumor micromilieu only correlated with IgG secretion (p = 0.0004). Supporting recent findings in several other tumor entities, TiBc in CRC thus likely can contribute to tumor control in a dual role of sole antigen-presentation and additionally anti-tumoral Ig-production.

scholarly journals TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation

2020 ◽  
Vol 21 (20) ◽  
pp. 7526
Author(s):  
Giacomo Lettini ◽  
Valentina Condelli ◽  
Michele Pietrafesa ◽  
Fabiana Crispo ◽  
Pietro Zoppoli ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cellular Differentiation ◽  
Hct116 Cell ◽  
Reporter Assay ◽  
Colorectal Carcinomas ◽  
Cancer Stemness ◽  
Protein Ubiquitination ◽  
Ligand Receptors ◽  
Multiple Levels

Wnt/β-Catenin signaling is involved in embryonic development, regeneration, and cellular differentiation and is responsible for cancer stemness maintenance. The HSP90 molecular chaperone TRAP1 is upregulated in 60–70% of human colorectal carcinomas (CRCs) and favors stem cells maintenance, modulating the Wnt/β-Catenin pathway and preventing β-Catenin phosphorylation/degradation. The role of TRAP1 in the regulation of Wnt/β-Catenin signaling was further investigated in human CRC cell lines, patient-derived spheroids, and CRC specimens. TRAP1 relevance in the activation of Wnt/β-Catenin signaling was highlighted by a TCF/LEF Cignal Reporter Assay in Wnt-off HEK293T and CRC HCT116 cell lines. Of note, this regulation occurs through the modulation of Wnt ligand receptors LRP5 and LRP6 that are both downregulated in TRAP1-silenced cell lines. However, while LRP5 mRNA is significantly downregulated upon TRAP1 silencing, LRP6 mRNA is unchanged, suggesting independent mechanisms of regulation by TRAP1. Indeed, LRP5 is regulated upon promoter methylation in CRC cell lines and human CRCs, whereas LRP6 is controlled at post-translational level by protein ubiquitination/degradation. Consistently, human CRCs with high TRAP1 expression are characterized by the co-upregulation of active β-Catenin, LRP5 and LRP6. Altogether, these data suggest that Wnt/β-Catenin signaling is modulated at multiple levels by TRAP1.

6103 Expression and role of placenta growth factor (PlGF) on colorectal carcinomas

2009 ◽  
Vol 7 (2) ◽  
pp. 353
Author(s):  
M. Baek ◽  
T. Ahn ◽  
D. Jeong ◽  
S. Cho ◽  
J. Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinomas ◽  
Placenta Growth Factor

scholarly journals Prognostic Role of Nucleophosmin in Colorectal Carcinomas

2014 ◽  
Vol 15 (5) ◽  
pp. 2021-2026 ◽  
Author(s):  
Yu-Feng Yang ◽  
Xi-Ying Zhang ◽  
Mei Yang ◽  
Ze-Hua He ◽  
Ning-Fu Peng ◽  
...  
Keyword(s):  
Colorectal Carcinomas ◽  
Prognostic Role
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