Study of association between chronic liver disease and thyroid function tests at a tertiary hospital

2021 ◽  
Vol 19 (1) ◽  
pp. 01-04
Author(s):  
S Bethiun ◽  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Thyroid Function ◽  
Tertiary Hospital ◽  
Chronic Liver ◽  
Thyroid Function Tests ◽  
Alcoholic Liver Cirrhosis ◽  
Free T4 ◽  
Thyroid Profile

Background: Among the various functions of liver, one function is synthesis of carrier proteins and metabolism of hormones and liver diseases, have been shown to be associated with various endocrinal disturbances. Aim of the study was to evaluate the spectrum of chronic liver disease and association between thyroid profile and severity of liver damage at a tertiary hospital. Material and Methods: Present study was single-center, hospital based, case-control study, conducted in 88 cases of liver cirrhosis/ chronic liver disease and 88 age/sex matched healthy controls (randomly selected from relatives attending OPD with patients) were studied. Thyroid function tests were done and compared among cases and controls. Results: In present study 88 cases of liver cirrhosis/ chronic liver disease and 88 healthy controls were studied. Mean age and gender were comparable in cases and controls and difference was not statistically significant. Most of cases had alcoholic liver cirrhosis (80.7 %), rest had non-alcoholic liver cirrhosis (12.5%) and chronic viral hepatitis (6.8%). As per Child-Pugh Score, most cases were from Child-Pugh B (42%), followed by Child-Pugh C (31.8%) and Child-Pugh A (26.1%). In present study free T3, free T4 and TSH were compared between cases and controls, abnormal values were noted in cases and statistically significant difference was noted. Serum thyroid profile abnormalities were noted as per advancement in Child-Pugh Score Classes and difference was statistically significant for free T3 and free T4. Conclusion: Thyroid function test abnormalities in circulating thyroid hormone concentrations were noted in patients liver cirrhosis as compared to healthy subjects and severe abnormalities were associated with advanced Child Pugh score.

scholarly journals Thyroid function tests in chronic liver disease: evidence for multiple abnormalities despite clinical euthyroidism.

Gut ◽  
1983 ◽  
Vol 24 (7) ◽  
pp. 631-636 ◽  
Author(s):  
M Borzio ◽  
R Caldara ◽  
F Borzio ◽  
V Piepoli ◽  
P Rampini ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Thyroid Function ◽  
Chronic Liver ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
Multiple Abnormalities

PREVALENCE OF THYROID DYSFUNCTION IN CHRONIC LIVER DISEASE

2021 ◽  
pp. 9-11
Author(s):  
Yash Desai ◽  
Shahid Haideri ◽  
Abhijit Basu ◽  
Prabhat Singh ◽  
Taniya Upadhyaya
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Tertiary Care ◽  
Chronic Liver ◽  
Function Evaluation ◽  
Thyroid Function Tests ◽  
Care Hospital ◽  
Disease Present

Introduction: Chronic Liver Disease affects most of the organs in the human body. Various studies have been done regarding chronic liver disease, but not many studies are done on the assessment of thyroid function in chronic liver disease. Present study thus aimed at assessing the thyroid functions in chronic liver disease patients. Materials & Methods: A hospital based cross-sectional study was conducted at a tertiary care hospital Study included 52 patients presenting with Chronic liver disease fullling the study criteria using purposive conservative sampling. Detailed examination was done for all cases including thyroid function tests. All analysis was carried out by using SPSS software version 21. Overall prevalence of thyroid dysfunction among chronic liver disease patients was 36.5%. A Results: signicant positive correlation was observed between severity of chronic liver disease and TSH levels (r-0.60) while an inverse correlation was observed with T3 and T4 levels (p<0.01). A signicant association was observed between presence of thyroid dysfunction among chronic liver disease patients who had hepatic encephalopathy (66.7% vs 32.6%; p<0.05). Also, a signicant association was observed with severity of chronic liver disease. Present study observed Conclusion: that derangement in thyroid prole is common in patients with cirrhosis of liver. A statistically signicant change was observed in serum T3 and T4 levels that tend to fall with progressive severity of chronic liver disease irrespective of aetiology. Thus all cirrhotic patients should undergo thyroid function evaluation as these patients are denitely associated with development of thyroid dysfunction.

scholarly journals Results of liver and spleen endoscopic ultrasonographic elastography predict portal hypertension secondary to chronic liver disease

2020 ◽  
Vol 08 (11) ◽  
pp. E1623-E1632
Author(s):  
Carlos Robles-Medranda ◽  
Roberto Oleas ◽  
Miguel Puga-Tejada ◽  
Manuel Valero ◽  
Raquel Del Valle ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Predictive Value ◽  
Strain Ratio ◽  
Chronic Liver ◽  
Spleen Stiffness ◽  
Eus Elastography ◽  
Sensitivity Specificity

Abstract Background and study aims Assessment of endoscopic ultrasonography (EUS)-elastography of the liver and spleen may identify patients with portal hypertension secondary to chronic liver disease. We aimed to evaluate use of EUS-elastography of the liver and spleen in identification of portal hypertension in patients with chronic liver disease. Patients and methods This was a single-center, diagnostic cohort study. Consecutive patients with liver cirrhosis and portal hypertension underwent EUS-elastography of the liver and spleen. Patients without a history of liver disease were enrolled as controls. The primary outcome was diagnostic yield of liver and spleen stiffness measurement via EUS-elastography in prediction of portal hypertension secondary to chronic liver cirrhosis. Cutoff values were defined through Youden’s index. Overall accuracy was calculated for parameters with an area under the receiver operating characteristic (AUROC) curve ≥ 80 %. Results Among the 61 patients included, 32 had cirrhosis of the liver. Liver and spleen stiffness was measured by the strain ratio and strain histogram, with sensitivity/(1 − specificity) AUROC values ≥ 80 %. For identification of patients with cirrhosis and portal hypertension, the liver strain ratio (SR) had a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 84.3 %, 82.8 %, 84.4 %, and 82.8 %, respectively; the liver strain histogram (SH) had values of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively. EUS elastography of the spleen via the SR reached a sensitivity, specificity, PPV, and NPV of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively, whereas the values of SH were 56.3 %, 89.7 %, 85.7 %, and 65.0 %, respectively. Conclusion Endoscopic ultrasonographic elastography of the liver and spleen is useful for diagnosis of portal hypertension in patients with cirrhosis.

THYROID FUNCTION AND THYROID REGULATION IN EUTHYROID MEN WITH CHRONIC LIVER DISEASE: EVIDENCE OF MULTIPLE ABNORMALITIES

1977 ◽  
Vol 7 (6) ◽  
pp. 453-461 ◽  
Author(s):  
J. R. B. GREEN ◽  
E. J. SNITCHER ◽  
N. A. G. MOWAT ◽  
R. P. EKINS ◽  
LESLEY H. REES ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Thyroid Function ◽  
Chronic Liver ◽  
Multiple Abnormalities

scholarly journals Burden of Liver Cirrhosis in Portugal between 2010 and 2017

2020 ◽  
pp. 1-9
Author(s):  
João Manuel Silva ◽  
Mário Jorge Silva ◽  
Filipe Calinas ◽  
Paulo Jorge Nogueira
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Liver Disease ◽  
Hospital Admissions ◽  
Chronic Liver ◽  
Years Of Life Lost ◽  
Hepatitis C Virus Infection

<b><i>Introduction:</i></b> Liver cirrhosis is a prevalent disease in Portugal. Recent changes in alcohol consumption, as well as the wide use of direct-acting antivirals for hepatitis C since 2015, may be contributing to changes in the national burden of liver cirrhosis in the last few years. <b><i>Objectives:</i></b> We aim to characterize the burden of cirrhosis in Portugal between 2010 and 2017. <b><i>Patients and Methods:</i></b> We analyzed all hospital admission episodes due to cirrhosis in Portugal Mainland between 2010 and 2017, registered in the national Diagnosis-Related Group database, according to etiology of cirrhosis. We also analyzed data on mortality and potential years of life lost from liver cirrhosis and chronic liver disease, retrieved from Statistics Portugal (National Institute for Statistics). <b><i>Results:</i></b> Between 2010 and 2017, a total of 51,438 admissions for liver cirrhosis occurred in Portugal. The annual number of admissions decreased (<i>p</i> = 0.044) during the analyzed period. The most frequent cause of cirrhosis was alcoholic liver disease, present in 78.9% of all admissions (<i>n</i> = 40,595), followed by chronic hepatitis C virus infection, present in 11.3% (<i>n</i> = 5,823). A male predominance was identified in the admissions for every analyzed cause of cirrhosis. Annual admissions for alcoholic cirrhosis remained stable (<i>p</i> = 0.075) during the 8-year period. The same stable tendency was observed in the number of admissions for cirrhosis caused by hepatitis C virus (<i>p</i> = 0.861) and alcohol plus hepatitis C virus infection (<i>p</i> = 0.082), although these admissions for hepatitis C-related cirrhosis increased until 2014–2015 and steadily decreased thereafter. Annual deaths due to liver cirrhosis and chronic liver disease decreased from 1,357 in 2010 to 1,038 in 2017 (<i>p</i> = 0.002). The number of potential years of life lost decreased as well in the period (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> The burden of cirrhosis, evaluated by hospital admissions, mortality, and potential years of life lost, decreased in Portugal between 2010 and 2017.

scholarly journals Chronic liver disease promotes lesions of the colorectal adenoma‐carcinoma sequence, independent of liver cirrhosis

2019 ◽  
Vol 7 (5) ◽  
pp. 662-672 ◽  
Author(s):  
Amelie S. Troschel ◽  
Alexander Miks ◽  
Fabian M. Troschel ◽  
Anna Hüsing-Kabar ◽  
Miriam Maschmeier ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Colorectal Adenoma ◽  
Chronic Liver

Liver cirrhosis: Child-Pugh grading of cases seen in Nigeria

2005 ◽  
Vol 35 (3) ◽  
pp. 169-171 ◽  
Author(s):  
D A Ndububa ◽  
O S Ojo ◽  
A O Aladegbaiye ◽  
R A Adebayo ◽  
V A Adetiloye ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Diagnostic Procedures ◽  
Chronic Liver ◽  
Surgical Interventions ◽  
B Virus ◽  
Time Of Presentation

Child-Pugh grading is an important determinant of treatment options, surgical interventions and prognosis in chronic liver disease. Sixty-four liver cirrhosis patients (49 men, 15 women) seen at Ile-Ife, Nigeria were graded according to the Child-Pugh parameters. Only one (1.6%) was in Class A, while 21 (32.8%) and 42 (65.6%) were in Classes B and C, respectively. Thirty-four either had coagulopathy or were already in encephalopathy at the time of presentation. Hepatitis B virus-associated disease was present in 64% of the patients. Most Nigerian cirrhosis patients present with very advanced disease; they are thus poor-risk candidates for diagnostic procedures and surgery. Efforts should be intensified at making the diagnosis at a much earlier stage and universal immunization with the hepatitis B vaccine should be commenced to reduce the incidence of HBV-related chronic liver disease in Nigeria.

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