Assessment of lung function and diffusion capacity among cases with and without microvascular complications of diabetes mellitus - A cross sectional study

2019 ◽  
Vol 10 (1) ◽  
pp. 42-47
Author(s):  
Karthikeyan Ganesan ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Function ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diffusion Capacity ◽  
Complications Of Diabetes ◽  
And Diffusion

scholarly journals Lung: Another Victim of the Silent killer Diabetes- A Cross-sectional Study

2020 ◽  
Author(s):  
Tirthankar Mukherjee ◽  
SR Sneha ◽  
NS Vinayaka
Keyword(s):  
Pulmonary Function ◽  
Normal Values ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diffusion Capacity ◽  
Duration Of Diabetes

Introduction: Diabetes is a multisystem disorder with well known complications involving various organs in the body. The presence of abundant connective tissue and microvasculature raises the possibility that lung may also be affected in diabetes. Aim: To evaluate the pulmonary function parameters in patients with diabetes mellitus and to determine their correlation with glycaemic control, duration of diabetes and other microvascular complications. Materials and Methods: This is a cross-sectional study done between September 2018 and March 2019. A total of 300 type 2 diabetic patients, aged 30-70 years, with duration of diabetes more than 1 year, were included in the study. Thorough history was taken regarding the duration of diabetes and symptoms of the complications. All of them were evaluated for diabetic microangiopathies: nephropathy (by 24 hour urinary protein excretion), retinopathy (by direct ophthalmoscopy) and neuropathy (by clinical examination). Glycosylated Haemoglobin (HbA1c) was measured as an indicator of glycaemic control. Spirometry and single breath diffusion capacity for carbon monoxide were performed on all the subjects. Pulmonary Function Test (PFT) parameters of each subject were compared with the normal values. Unpaired t-test and one-way analysis of variance (ANOVA) were used. Correlation and regression studies were used to find out the strength of association between Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO) and the following: the duration of disease, HbA1c and presence of other microvascular complications. Results: Pulmonary function parameters like Forced Expiratory Volume in first second (FEV1), Forced Vital Capacity (FVC), Peak Expiratory Forced Rate (PEFR) and DLCO were below the normal values in 53% of diabetic patients included in the study. Majority of them had a restrictive ventilation pattern. The diffusion capacity corrected for Alveolar Volume (VA) as measured by DLCO/VA was significantly reduced in those with longer duration of diabetes and in those with other microvascular complications. However, the poor lung functions had no correlation with the HbA1C values. Conclusion: This study demonstrated that lungs are indeed affected in patients with type 2 diabetes. The presence of extrapulmonary microangiopathy and duration of the disease may predict the incidence and the severity of the lung function abnormality.

scholarly journals A cross sectional study to assess knowledge attitude and practices of type 2 diabetes mellitus in urban and rural population of Maharashtra

2019 ◽  
Vol 6 (12) ◽  
pp. 5262
Author(s):  
Swati T. Dahake ◽  
Uzma A. Shaikh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Rural Health ◽  
Rural Population ◽  
Health Centre ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Complications Of Diabetes

Background: Prevalence of type 2 diabetes is increasing globally, more so in developing countries like India due to rapid urbanization. As India ranks first in diabetes prevalence and will continue to do so in 2025, we must prevent the disease by various measures. Therefore, prevention is important aspects. The aim of the study was to assess the knowledge, attitude and practices of patients having type 2 diabetes mellitus.Methods: A cross sectional study was done in the urban and rural health centre among 100 diabetes patients in each. Data were collected regarding their knowledge, attitude and practices about diabetes and associated risk factors. Data was analyzed by SPSS 20 version.Results: Mean age of the study respondents were 50.45 and 52.50 years in urban and rural health centers respectively. We found that most patients are having good knowledge about diabetes mellitus in urban health centre while rural population had low knowledge. Both groups had most subjects with low level of education and low income groups. Very low percent of people know about the complications of diabetes mellitus in both the groups.Conclusions: This study showed that there was good knowledge, attitude and practice in urban and very poor knowledge, attitude and practices in rural about the diabetes which needs to be increased. Life style modification is needed for reducing the complications of diabetes mellitus. 

scholarly journals A Cross-sectional Study to Assess Neutrophil Lymphocyte Ratio as a Predictor of Microvascular Complications in Type 2 Diabetes Mellitus Patients

2021 ◽  
Author(s):  
Sutanay Bhattacharyya ◽  
Neelima Jain ◽  
Himanshu Verma ◽  
Kavish Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Absolute Number ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio

Introduction: Neutrophil Lymphocyte Ratio (NLR) is a novel marker of chronic inflammation that exhibits a balance of two interdependent components of the immune system and can be used to predict microvascular complications in diabetes. Aim: To study the NLR in type 2 diabetes patients and its association with microvascular complications in these patients. Materials and Methods: This was a cross-sectional study conducted over 18 months at Safdarjung Hospital, New Delhi. Eighty patients of type 2 Diabetes Mellitus (DM) were selected for the study. Detailed history was taken including duration of DM, symptoms suggestive of any complications or co-morbidity and treatment history. Physical examination (height and weight) and systemic examination was performed to check for presence of any diabetic complications. NLR was obtained from the complete blood counts by dividing the absolute number of neutrophils to the absolute number of lymphocytes. Data recorded were analysed using Statistical Package for Social Sciences (SPSS) software version 21.0 Logistic regression analysis and Receiver Operating Curve (ROC) curve were used. Results: Total 38.7% (31) of the patients had high NLR, with mean±Standard Deviation (SD) of NLR being 3.29±1.49. There was a statistically significant association between poorly controlled diabetes HbA1C >7%, high-sensitivity C-Reactive Protein (hs-CRP) levels and NLR. NLR was found to be the best predictor of diabetic neuropathy and diabetic nephropathy. NLR was also significantly higher in DM patient having more than one microvascular complication. Conclusion: NLR can be used as a simple parameter to predict presence of diabetic microvascular complications. Thus, an early diagnosis and subsequently targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes related complications.

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