Effects on nondepolarizing muscle relaxant by different doses of magnesium sulphate to conduct relaxant anaesthesia

2020 ◽  
Vol 13 (1) ◽  
pp. 07-11
Author(s):  
Moona Abdul Kadiru ◽  
◽  
Keerthi Premchandran ◽  
Ravi Kumar ◽  
◽  
...  
Keyword(s):  
Muscle Relaxant ◽  
Magnesium Sulphate ◽  
Nondepolarizing Muscle Relaxant ◽  
Different Doses

The Effect of Small Dose of Nondepolarizing Muscle Relaxant Administered Prior to Succinylcholine on Intubating Condition

1993 ◽  
Vol 26 (1) ◽  
pp. 50
Author(s):  
Jin Seung Lee ◽  
Jang Weon Lee ◽  
Si Young Ok ◽  
Yoo Jae Kim ◽  
Wook Park ◽  
...  
Keyword(s):  
Muscle Relaxant ◽  
Small Dose ◽  
Nondepolarizing Muscle Relaxant

Effect of maintenance bolus on the recovery profile of a short-acting nondepolarizing muscle relaxant

2002 ◽  
Vol 14 (7) ◽  
pp. 500-504
Author(s):  
Xiaoguang Chen ◽  
Jun Tang ◽  
Paul F White ◽  
Ronald H Wender ◽  
Alexander Sloninsky ◽  
...  
Keyword(s):  
Muscle Relaxant ◽  
Short Acting ◽  
Recovery Profile ◽  
Nondepolarizing Muscle Relaxant

scholarly journals Evaluation of Two Different Doses of Pre-Emptive Intravenous Magnesium Sulphate as Post- Operative Adjunct Analgesia after Gynaecological Surgery

2020 ◽  
Vol 15 (2) ◽  
pp. 164-174
Author(s):  
Joanna Ooi Su Min ◽  
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Pain Score ◽  
Magnesium Sulphate ◽  
Gynaecological Surgery ◽  
Patient Controlled Analgesia ◽  
Analgesic Effects ◽  
Intravenous Magnesium ◽  
Group I ◽  
Different Doses

This study compared the analgesic effects of pre-emptive intravenous magnesium sulphate of different dosages in patients undergoing lower abdominal gynaecological surgery. Fifty-six patients with Body Mass Index (BMI) <35 kg/m2 who underwent lower abdominal gynaecological surgery were randomly recruited into two groups. Group I received one ampoule (2.47 g) of magnesium sulphate and Group II received 50 mg/kg magnesium sulphate (based on body weight), pre-operatively. Pain score and patient controlled analgesia (PCA) morphine requirement were compared at 30 minutes, 12 hours and 24 hours post-operatively. The pain score was comparable at all intervals between the two groups (30 minutes, p = 0.450; 12 hours, p = 0.402; and 24 hours, p = 1.000). Post-operative PCA morphine requirement was not statistically significant between the two groups at 30 minutes, 12 hours, and 24 hours (2.7 vs 2.4 mg, p = 0.545; 12.5 vs 9.8 mg, p = 0.154; 7.7 vs 6.4 mg, p = 0.323). The side-effects of magnesium sulphate on blood pressure, heart rate and sedation were not statistically significant between the two groups. In conclusion, the analgesic effects of pre-emptively administered intravenous MgSO4 of 2.47 g (one ampule) was comparable to 50 mg/kg in patients with BMI less than 35 kg/m2 following lower abdominal gynaecological surgery under general anaesthesia with negligible side effects.

EVALUATION OF CENTRALLY ACTING SKELETAL MUSCLE RELAXANT ACTIVITY OF ALCOHOLIC EXTRACTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ROOTS IN ALBINO MICE.

2021 ◽  
pp. 62-64
Author(s):  
Sarita Panigrahy ◽  
Sangeeta Panigrahy
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Withania Somnifera ◽  
Standard Drug ◽  
Alcohol Extract ◽  
Skeletal Muscle Relaxant ◽  
Albino Mice ◽  
Muscle Relaxant Activity ◽  
Off Time ◽  
Different Doses

BACKGROUND:Skeletal muscle relaxants are drugs that are used to relax and diminish tightness in muscles. Many medicinal plants have known to have skeletal muscle relaxant activity. In past studies some Polyherbal formulation containing Ashwagandha as one of the ingredients and its fat extract have shown to have skeletal muscle relaxant activity in experimental animal models. This study is intended to evaluate the skeletal muscle relaxant activity of alcoholic extracts of Withania Somnifera (Ashwagandha) roots in albino mice, as the literature regarding this extract is scarce. METHODOLOGY: Standard drug (diazepam), different doses of Alcohol extract of ashwagandha (50,100, 150 mg/kg) were given orally to mice and muscle relaxant activity was assessed by Rota-rod apparatus. The fall off time from the rotating rod was noted for each group after 1 hour of drug administration. The difference in fall off time among the standard drug and treated mice was taken as an index of muscle relaxation. RESULTS:The test extract at its different doses showed highly signicant reduction in the time spent by the animals on revolving rod in rotarod test when compared to baseline (p < 0.0001) which is highly signicant. On comparison with diazepam, different doses of Alcohol extract showed weak relaxant activity. CONCLUSIONS : The three different doses of Alcoholic extract showed a dose dependent rise in muscle relaxant action. The results are promising for further investigation of efcient skeletal muscle relaxant activity.

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