Study of seroprevalence of Hepatitis A and profile of patients in clinically suspected cases of acute viral Hepatitis at a tertiary care hospital

2021 ◽  
Vol 19 (2) ◽  
pp. 32-36
Author(s):  
Pradnya Gaikwad ◽  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

Viral Hepatitis A Infection among Adolescent and Adult Patients in Tertiary Care Hospital

2014 ◽  
Vol 4 ◽  
pp. S10-S11
Author(s):  
Arun Kumar Sharma ◽  
Uma Debi ◽  
Babu Ram Thapa ◽  
Rakesh Kochhar ◽  
Deepak Kumar Bhasin
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Adult Patients ◽  
Care Hospital ◽  
Viral Hepatitis A

scholarly journals CLINICAL PROFILE OF ACUTE VIRAL HEPATITIS PATIENTS AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA- AN OBSERVATIONAL STUDY

2019 ◽  
Vol 6 (6) ◽  
pp. 384-388
Author(s):  
Rajesh Kumar Arya ◽  
Sudhir Kumar Verma ◽  
Vivek Kumar ◽  
Satyendra Kumar Sonkar ◽  
Ajay Kumar ◽  
...  
Keyword(s):  
Observational Study ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Care Hospital ◽  
Northern India

scholarly journals Seroprevalence of Enterically Transmitted Hepatitis Viruses in Patients Attending a Tertiary Care Hospital in Maharashtra, India

2021 ◽  
Vol 10 (30) ◽  
pp. 2310-2313
Author(s):  
Suvarna Vaibhav Sande
Keyword(s):  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Predictive Value ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Care Hospital ◽  
Serum Samples ◽  
Hepatitis Viruses

BACKGROUND Hepatitis A & E viruses are enterically transmitted viruses responsible for acute viral hepatitis in developing countries. Hepatitis A virus (HAV) has worldwide distribution while hepatitis E virus (HEV) is restricted to tropical countries. HAV affects infants and young children while HEV affects older children and young adults. This study was conducted to determine the seroprevalence of HAV and HEV and their co-infection in patients presenting with acute viral hepatitis (AVH). METHODS 200 sera of patients suffering from suspected acute viral hepatitis (AVH) attending tertiary care rural hospital JNMC Sawangi, Wardha were included in the study. Serum samples were tested for IgM anti HAV and IgM anti - HEV for the detection of acute hepatitis A and acute hepatitis E using commercially available ELISA kit & Immunochromatography test (ICT) for comparison of ELISA and ICT. RESULTS The overall seroprevalence of HAV and HEV infection was found to be 19 %. The seroprevalence of HAV infection was found to be 13 %, HEV infection 5 % and HAV - HEV co - infection 1 %. HAV infection in males and females was found to be 16.07 % and 9.09 % respectively & HEV infection was found to be 5.35 % and 4.54 % respectively. In case of detection of HAV IgM, two serum samples were negative by ICT but positive by ELISA & for HEV IgM, one serum sample was negative by ICT but positive by ELISA. The sensitivity, specificity, positive predictive value and negative predictive value of HAV IgM was found to be 96 %, 98.8 %, 92.30 % & 99.43 % and for HEV IgM was found to be 90 %, 99.47 %, 90 % & 99.47 % respectively. CONCLUSIONS It is evident from this study that infection with enteric hepatitis viruses is not infrequent. Findings from this study emphasize the need to establish regular seroepidemiological surveys to keep track of epidemiology of these viruses. Results from rapid tests are comparable to ELISA with additional advantage of ease of interpretation and neither time consuming nor requiring special instruments. KEY WORDS Hepatitis A, Hepatitis E, Seroprevalence

scholarly journals Co-infection of Hepatitis A and Hepatitis E Viruses among the Acute Viral Hepatitis Cases in Tertiary Care Hospital –A Four Years Retrospective Study

2020 ◽  
Vol 14 (3) ◽  
pp. 2047-2051
Author(s):  
Ravindra V. Shinde ◽  
Anjali R. Shinde ◽  
Anjali D. Patil ◽  
S.K. Pawar ◽  
S.T. Mohite ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Care Center ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Care Hospital ◽  
Age Group ◽  
Tertiary Care Centre ◽  
Health Care Center

Acute viral hepatitis(AVH) is caused by Hepatitis A (HAV) and Hepatitis E(HEV). It is major health burden in India. Both the viruses HAV and HEV are primarily transmitted via the faeco-oral course. Study was conducted to determine the seroprevalence of HAV, HEV and rate of co-infection in AVH patients attending rural tertiary care centre. A retrospective laboratory record based study was carried out in rural tertiary health care center located in Western Maharashtra. Laboratory and Medical records of suspected acute viral infection patients were analyzed during study. Study period was June 2014 to July 2018. Commercially available ELISA kits of IgM anti-HAV and IgM anti-HEV were used to analyze serum samples of suspected study participants. Tests were carried out as per the manufacturer’s instructions. A total of 778 acute viral hepatitis cases were included in the study from July 2014 to July 2018 among which 85/778 (10.9 %) detected positive for HAV and 121/778 (15.6%) detected positive for HEV. Co-infection was identified in 6/778(0.8 %). Jaundice, fever fatigue and hepatomegaly were common clinical presentation in HAV, HEV and confection with both viruses in acute viral hepatitis patients. Study indicated low exposure to HAV in childhood bellow 16 years. Co-infection rate was detected high in 16-25 years age group. Vaccination policy against HAV in adolescent age group needed as there is change epidemiological shift of HAV which has been observed in the current study. These data will helps for planning future vaccination strategies, better implementation sanitation program, and safe water supply in this geographic area.

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