A study of prevalence of anti-chlamydia pneumoniae antibodies in adult and paediatric asthmatic patients

2021 ◽  
Vol 17 (3) ◽  
pp. 29-32
Author(s):  
Vaishnavi Madavi ◽  
Keyword(s):  
Chlamydia Pneumoniae ◽  
Asthmatic Patients

Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients

2016 ◽  
Vol 77 (5) ◽  
pp. 382-388 ◽  
Author(s):  
Tamar A. Smith-Norowitz ◽  
Kobkul Chotikanatis ◽  
David P. Erstein ◽  
Jason Perlman ◽  
Yitzchok M. Norowitz ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Chlamydia Pneumoniae ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Asthmatic Patients ◽  
Blood Mononuclear Cells

scholarly journals Antichlamydia IgG Antibody in Adult Asthmatics in Al-Najaf

2020 ◽  
Author(s):  
Iman Jabbar Kadhim Al-Ghizzi ◽  
Israa Khudhair Abbas ◽  
Suaad Muhammed Hassan Rasheed ◽  
Falah Abdulhasan Deli
Keyword(s):  
Chlamydia Pneumoniae ◽  
Inverse Correlation ◽  
Control Group ◽  
Igg Antibody ◽  
Asthmatic Patients ◽  
Test Parameters ◽  
Medical City ◽  
Asthma And Allergy ◽  
The Difference ◽  
And Gender

Infection is presumed to have a rule in the promotion of asthma exacerbations, and in deterioration of the course of the disease, Chlamydia pneumoniae (C. pneumoniae) is claimed to be a possible cause for these two issues. To assess the positivity and the titer of C. pneumoniae IgG antibodies in relation to the state of asthma and its severity. 61 asthmatic patients aged 15-85 years (mean of 47.10±14.887), and 29 apparently healthy, nonasthmatic age and gender-matched volunteers (control group) were assessed as at Asthma and Allergy Clinic in Al-Sader Medical City in AL-Najaf province, Chlamydia Pneumoniae IgG ELISA Kit was used for the detection of IgG antibody to C. Pneumoniae in human serum to detect chronic infection, and Spirometric test was done, and the best results for FEV1 and PEFR were taken. IgG antichlamydial antibodies were positive in 21 (34.4%) of patients compared to 4 (13.8%) of controls, and the difference was significant with OR=3.281, the seropositivity in acute exacerbation was more than in stable asthmatic, 43.8% vs. 24.1% (P=0.029), seropositivity was nonsignificantly more in moderate and severe asthma as compared with mild asthma, a significant inverse correlation between IgG titer and pulmonary function test parameters (FEV1, PEFR) was observed as the FEV1 & PEFR values decrease with increase IgG titer. Chronic C. pneumoniae infection is common in adult asthmatics and correlated with exacerbations & increased severity and disturbed lung function.

scholarly journals Chlamydia pneumoniae Influence on Cytokine Production in Steroid-Resistant and Steroid-Sensitive Asthmatics

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 112
Author(s):  
Dóra Paróczai ◽  
Tímea Mosolygó ◽  
Dávid Kókai ◽  
Valéria Endrész ◽  
Dezső P. Virok ◽  
...  
Keyword(s):  
Chlamydia Pneumoniae ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Inhaled Corticosteroids ◽  
Asthma Management ◽  
Peripheral Blood Mononuclear ◽  
Steroid Resistant ◽  
Asthmatic Patients ◽  
Tnf Α ◽  
Steroid Sensitive

Medications for asthma management consisting of inhaled corticosteroids act by controlling symptoms. However, some patients do not respond to steroid treatment due to immunological factors at the cytokine level. Chlamydia pneumoniae (C. pneumoniae) infection is strongly implicated in asthma pathogenesis, causing altered immune responses. We investigated the association of C. pneumoniae serostatus with the production of certain cytokines by peripheral blood mononuclear cells (PBMCs) of steroid-resistant and -sensitive asthmatic patients. Our most important findings are the following: In the case of C. pneumoniae seropositive patients we detected pronounced spontaneous interleukin (IL)-10 secretion and, in the case of steroid-resistant patients, IL-10 secretion was at a significantly higher level as compared with in-sensitive patients (p < 0.01). Furthermore, steroid-resistant seropositive patients produced a significantly higher level of IL-10 spontaneously and under antigen stimulation as compared with steroid-resistant seronegative individuals (p < 0.05). Concerning spontaneous TNF-α secretion by C. pneumoniae seropositive asthmatics, we observed that steroid-resistant patients produced significantly more of this cytokine than steroid-sensitive patients. In the steroid-resistant patients’ sera, a remarkably high MMP-9 concentration was associated with C. pneumoniae seronegativity. Our study revealed that the differences in the cytokine production in steroid-sensitive and -resistant asthmatic patients can be influenced by their C. pneumoniae serostatus.

Chlamydia pneumoniae infection in asthmatic patients

2007 ◽  
Vol &NA; ◽  
pp. S248-S249
Author(s):  
Dejan Dokic ◽  
Zlatica Goseva ◽  
Elena Trajkovska-Dokic ◽  
Beba Veljanovska ◽  
Dimitar Krkinski
Keyword(s):  
Chlamydia Pneumoniae ◽  
Asthmatic Patients

Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

1986 ◽  
Vol 44 ◽  
pp. 354-355
Author(s):  
Kate W. Sjoerdsma ◽  
W. James Metzger
Keyword(s):  
Allergic Rhinitis ◽  
Bronchoalveolar Lavage ◽  
Allergic Asthma ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin ◽  
Human Eosinophil ◽  
Asthmatic Patients ◽  
Allergic Asthmatic ◽  
History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatic patients

1997 ◽  
Vol 27 (4) ◽  
pp. 396-405 ◽  
Author(s):  
L. M. TERAN ◽  
M. G. CAMPOS ◽  
B. T. BEGISHVILLI ◽  
J.-M. SCHRODER ◽  
R. DJUKANOVIC ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Asthmatic Patients ◽  
Chemotactic Factors

Effekt von Dexamethason auf die Chlamydia pneumoniae-induzierte Mukusexpression in Zellkultur und humaner Atemwegsmukosa

Pneumologie ◽  
2008 ◽  
Vol 62 (S 2) ◽  
Author(s):  
H Hauber ◽  
T Goldmann ◽  
E Vollmer ◽  
B Wollenberg ◽  
J Rupp ◽  
...  
Keyword(s):  
Chlamydia Pneumoniae
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