scholarly journals A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

2021 ◽  
Vol 19 (2) ◽  
pp. 22-25
Author(s):  
Joel Sabu ◽  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Serum Level ◽  
Cancer Patients ◽  
Serum Levels ◽  
Haematological Parameters ◽  
Oral Carcinogenesis ◽  
Group I ◽  
Iron And Zinc ◽  
Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

ELEMENTAL ANALYSIS OF BLOOD IN ORAL CANCER

2002 ◽  
Vol 12 (01n02) ◽  
pp. 41-46 ◽  
Author(s):  
T. R. RAUTRAY ◽  
V. VIJAYAN ◽  
P. K. HOTA
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Epidemiological Studies ◽  
Spectroscopic Technique ◽  
Control Group ◽  
Carcinogenic Effect ◽  
Carcinogenic Agents ◽  
Oral Cancer Patients ◽  
Oral Malignancies

Fluctuations of the concentration levels of trace elements play an egregious role in enhancing carcinogenic effect in healthy persons and in the pathogenesis of oral malignancies. Epidemiological studies regarding the role of external carcinogenic agents in oral cancer have documented the involvement of certain trace elements either directly or indirectly. An analysis of trace elements like K, Ca, Fe, Cu, Zn, Se And Pb was done in seventeen oral cancer patients having tobacco habits by drawing their whole blood and determining their concentrations using Energy Dispersive X-ray Fluorescence (EDXRF) spectroscopic technique at Institute of Physics. Bhubaneswar, India which is rapid, efficient, multi-elemental and non-destructive in nature and in principle sensitive to all elements from Na to U. Fifteen healthy non-cancerous persons with tobacco habits were also taken as control. The results of the study group when compared with the control group illustrated that K, Cu and Se concentrations were significantly higher in the oral cancer patients as an effect of deleterious tobacco upon their blood whereas the rest of the elements like Ca, Zn, Fe and Pb did not reveal significant changes.

scholarly journals Clinical studies on the serum levels of immunosuppressive acidic protein (IAP) of oral cancer patients

1980 ◽  
Vol 26 (6) ◽  
pp. 1415-1421 ◽  
Author(s):  
Motohiro WATANABE ◽  
Masashi NUMATA ◽  
Naoya TASHIRO ◽  
SUSUMU HAYASHI ◽  
Keiji TAMURA ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Clinical Studies ◽  
Serum Levels ◽  
Acidic Protein ◽  
Immunosuppressive Acidic Protein ◽  
Oral Cancer Patients

scholarly journals Possible role for interleukins as biomarkers for mortality and recurrence in oral cancer

2015 ◽  
Vol 30 (2) ◽  
pp. 262-266 ◽  
Author(s):  
Paolo G. Arduino ◽  
Elisa Menegatti ◽  
Nazario Cappello ◽  
Eugenio Martina ◽  
Nicolò Gardino ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Univariate Analysis ◽  
Cancer Recurrence ◽  
Serum Levels ◽  
Controlled Study ◽  
Oral Cancer Patients ◽  
Healthy Control ◽  
Prospective Controlled Study ◽  
Larger Sample

Background Salivary and serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) have previously been studied in oral cancer with conflicting results. Methods We designed a controlled study to assess the correlation between pretreatment salivary and serum levels of IL-6 and IL-8, and all-cause survival and cancer recurrence in oral cancer patients. Results Fifty-two oral cancer patients and 52 healthy control cases were selected. In univariate analysis, salivary IL-6 and IL-8 seemed to be more expressed in cases (p<0.001 and p = 0.010, respectively). Multivariate analysis showed that higher pretreatment saliva IL-6 levels were significantly associated with better survival (hazard ratio [HR] = 8.62; 95% confidence interval [95% CI], 1.21-62.50; p = 0.031). Conclusions To date, this is the largest prospective controlled study that has analyzed the pretreatment salivary and serum levels of IL-6 and IL-8 in oral cancer patients, suggesting salivary IL-6 as a possible prognostic biomarker. But further validation in a larger sample is still necessary.

scholarly journals A prospective study for Assessment of saliva CA- 125 level in oral cancer patients

2021 ◽  
Vol 15 (7) ◽  
pp. 1922-1925
Author(s):  
Arafat Ahmad ◽  
Usama Bin Ghaffar ◽  
Sanket Dadarao Hiware ◽  
Mohammed Taher Ali ◽  
Samina Wasi
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Stage Iv ◽  
Ca 125 ◽  
Group I ◽  
Whole Saliva ◽  
Oral Cancer Patients ◽  
Poorly Differentiated ◽  
Well Differentiated ◽  
A Prospective Study

Aim: To detect CA- 125 level in saliva of oral cancer patients. Methodology: A total of fifty- six SCC patients and thirty healthy subjects were selected. A non- stimulated whole saliva (5cc) was collected and evaluated for CA- 125 level ELISA. Results: A higher salivary CA 125 level (514.2±132.6 U/mL) was observed in poorly differentiated SCC followed by moderately differentiated (340.6±80.2 U/mL) and minimum values was observed in well differentiated SCC (236.2±76.2 U/mL). The mean± SD CA- 125 level in group I patients was 428.5± 110.2 U/mL and in group II was 132.4± 58.6 U/mL. Higher salivary CA 125 level (520.5±168.4 U/mL) was observed in stage IV and minimum in stage I (165.2±46.2 U/mL) which was statistically significant (P< 0.05). Conclusion: Patients with poorly differentiated SCC, cases of buccal mucosa and stage IV exhibited higher values of salivary CA- 125 level as compared to healthy control. Key words: Oral Cancer, Saliva, Tongue, CA- 125

scholarly journals Correlation between Loss of E-cadherin, Matrix-metalloproteinases and c-Jun expression in Oral Carcinogenesis

2017 ◽  
Vol 3 (1) ◽  
pp. 1-24
Author(s):  
Bhairavi N. Vajaria ◽  
Kinjal R. Patel ◽  
Rasheedunnisa Begum ◽  
Franky D. Shah ◽  
Jayendra B. Patel ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Gelatin Zymography ◽  
Mrna Levels ◽  
Normal Tissues ◽  
Oral Carcinogenesis ◽  
Oral Cancer Patients ◽  
Mrna And Protein Expression ◽  
Oral Precancerous Conditions ◽  
E Cadherin

Background: Earlier invitro studies have observed that loss of E-cadherin is responsible for progression and metastasis of cancer by upregulation of c-Jun protein. There being lack of simultaneous evaluation of matrix metalloproteinase (MMP) -2 and -9, E-cadherin and c-Jun mRNA and protein. Objective: This study aimed to correlate the above-mentioned parameters to evaluate the pathway of oral carcinogenesis. Methods: The study included 100 controls, 50 patients with oral precancerous conditions (OPC) and 100 oral cancer patients. MMPs were evaluated by gelatin zymography, ECAD and CJUN mRNA and protein expression by semi quantitative RT-PCR and western blot respectively. Results: The levels of active and total MMP-2 and MMP-9 were significantly higher in patients with OPC and oral cancer patients as compared to controls. A significant increase in truncated E-cadherin and c-Jun protein was observed in malignant tissues as compared to adjacent normal tissues while CJUN mRNA levels were comparable. Higher values of c-Jun protein and MMPs, and lower values of ECAD mRNA were associated with reduced overall survival. A positive correlation was observed between truncated E-cadherin, MMPs and c-Jun protein. Conclusions: MMPs modulate cell-cell adhesion by increasing truncation of E-cadherin resulting in loss of E-cadherin which is responsible for upregulation of c-Jun protein in oral cancer.

scholarly journals Status of trace elements in saliva of oral precancer and oral cancer patients

2015 ◽  
Vol 11 (1) ◽  
pp. 146 ◽  
Author(s):  
ShishirRam Shetty ◽  
Subhas Babu ◽  
Suchetha Kumari ◽  
Pushparaja Shetty ◽  
Shruthi Hegde ◽  
...  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Oral Precancer ◽  
Oral Cancer Patients

scholarly journals High Expression of KLF10 Is Associated with Favorable Survival in Patients with Oral Squamous Cell Carcinoma

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 17
Author(s):  
Chung-Min Yeh ◽  
Yi-Ju Lee ◽  
Po-Yun Ko ◽  
Yueh-Min Lin ◽  
Wen-Wei Sung
Keyword(s):  
Survival Rate ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Protective Factor ◽  
Female Gender ◽  
Vital Role ◽  
Cancer Stage ◽  
Independent Prognostic Marker ◽  
Oral Cancer Patients ◽  
The Impact

Background and objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan–Meier analysis and the Cox proportional hazard model. Results: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. Conclusions: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.

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