scholarly journals Influence of endothelial nitric oxide synthase gene intron 4 VNTR polymorphism on serum nitric oxide level among healthy south-Indian population

2021 ◽  
Vol 19 (2) ◽  
pp. 16-21
Author(s):  
G Sasirekha ◽  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide Synthase ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
Nitric Oxide Level ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4

Background: Nitric oxide (endothelium derived relaxing factor) is synthesized from L-arginine by nitric oxide synthases. Endothelial NOS is responsible for most of the nitric oxide produced under physiological conditions. Acting via cGMP NO cause smooth muscle relaxation, prevents platelet aggregation and acts as an anti-inflammatory agent thereby playing a vital role in regulating vascular tone. Various studies have postulated the role of Nitricoxide in vascular disorders like hypertension and atherosclerosis. This study is aimed to find out the influence of endothelial nitric oxide synthase gene intron 4 VNTR polymorphism on Serum nitric oxide level among healthy South-Indian Population. Genotype analysis was done on 282 randomly selected healthy individuals by polymerase chain reaction. Phenotype analysis of eNOS activity was done by measuring serum NOx level. Significantly lower eNOS activity (10.5 versus 18.3, P value is < 0.00001) among ‘a’ alleles when compared to ‘b’ alleles. We have found the presence of eNOS ‘a’ allele is found to decrease serum NOx level. As the distribution of ‘a’allele is lower among the population, a larger study is needed to find the role of eNOS intron4 gene in maintaining serum Nitric oxide level.

Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population

2012 ◽  
Vol 40 (2) ◽  
pp. 1275-1281 ◽  
Author(s):  
Annan Sudarsan Arun Kumar ◽  
Gurusamy Umamaheswaran ◽  
Ramamoorthy Padmapriya ◽  
Jayaraman Balachandar ◽  
Chandrasekaran Adithan
Keyword(s):  
Nitric Oxide ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population

2008 ◽  
Vol 395 (1-2) ◽  
pp. 134-136 ◽  
Author(s):  
Ramu Periaswamy ◽  
Umamaheswaran Gurusamy ◽  
Deepak Gopal Shewade ◽  
Akkarapatty Cherian ◽  
Rathinam Palamalai Swaminathan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide Synthase ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
Specific Association ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Gender Specific ◽  
Glu298asp Polymorphism

scholarly journals Role of Endothelial Nitric Oxide Synthase Gene Polymorphisms in Predicting Aneurysmal Subarachnoid Hemorrhage in South Indian Patients

2008 ◽  
Vol 24 (6) ◽  
pp. 333-339 ◽  
Author(s):  
Linda Koshy ◽  
H. V. Easwer ◽  
N. V. Neetha ◽  
Chandrasekhar Natarajan ◽  
R. N. Bhattacharya ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Subarachnoid Hemorrhage ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
South Indian ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been implicated as predisposing genetic factors that can predict aneurysmal subarachnoid hemorrhage (aSAH), but with controversial results from different populations. Using a case-control study design, we tested the hypothesis whether variants ineNOSgene can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We enrolled 122 patients, along with 224 ethnically matched controls. We screened the intron-4 27-bp VNTR, the promoter T-786C and the exon-7 G894T SNPs in theeNOSgene. We found marked interethnic differences in the genotype distribution ofeNOSvariants when comparing the South Indian population with the reported frequencies from Caucasian and Japanese populations. Genotype distributions in control and patient populations were found to be in Hardy-Weinberg equilibrium. In patients, the allele, genotype and estimated haplotype frequencies did not differ significantly from the controls. Multiple logistic regression indicated hypertension and smoking as risk factors for the disease, however the risk alleles did not have any interaction with these risk factors. Although theeNOSpolymorphisms were not found to be a likely risk factor for aSAH, the role of factors such as ethnicity, gender, smoking and hypertension should be evaluated cautiously to understand the genotype to phenotype conversion.

Endothelial nitric oxide synthase polymorphism and venous thromboembolism: A meta-analysis of 9 studies involving 3993 subjects

2021 ◽  
pp. 026835552110166
Author(s):  
Guangbin Huang ◽  
Xuejun Deng ◽  
Yanan Xu ◽  
Pan Wang ◽  
Tao Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Venous Thromboembolism ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Meta Analysis ◽  
Enos Polymorphism ◽  
The Difference ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Intron 4

Background Endothelial nitric oxide synthase (eNOS) polymorphism may influence the risk of venous thromboembolism (VTE). However, data from published studies with low statistical power are inconclusive. The present meta-analysis aimed to assess the relationship between eNOS polymorphism and the risk of VTE. Method Case-control studies evaluating the association between the eNOS polymorphism and VTE were searched in PubMed, Embase, Web of Science, Google Scholar, Wanfang, Chinese National Knowledge Infrastructure (CNKI), the Chongqing VIP Chinese Science and Technology Periodical Database (VIP), and Chinese Biomedical Literature Database (CBM). Results A total of 1588 cases and 2405 controls from 9 studies were included in the analysis. The results showed that eNOS G894T polymorphism was related to VTE susceptibility and the difference was statistically significant [T vs G: OR = 1.41, 95% CI (1.13, 1.75), P = 0.002; TT + GG vs TG: OR = 0.71, 95% CI (0.60, 0.84), P = 0.000; TT + TG vs GG: OR = 1.45, 95% CI (1.23, 1.70), P = 0.000]. Additionally, eNOS Intron 4 VNTR polymorphism was related to VTE susceptibility and the difference was statistically significant [4b4b vs 4a4a + 4a4b: OR = 2.77, 95% CI (1.01, 7.61), P = 0.048]. Conclusion ENOS G894T and eNOS Intron 4 VNTR polymorphisms were associated with VTE susceptibility, especially in Asian populations. However, multicenter studies with larger samples should be conducted to further clarify this association and verify our findings.

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