scholarly journals Characterisation of streptozotocin induced diabetes mellitus in Wistar albino rats - A histological and haematological perspective

2020 ◽  
Vol 13 (2) ◽  
pp. 33-36
Author(s):  
Rajesh R ◽  
◽  
Sreekala V ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Albino Rats ◽  
Streptozotocin Induced Diabetes ◽  
Wistar Albino Rats

scholarly journals The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

2017 ◽  
Vol 95 (11) ◽  
pp. 1343-1350
Author(s):  
Aleksandra Vranic ◽  
Stefan Simovic ◽  
Petar Ristic ◽  
Tamara Nikolic ◽  
Isidora Stojic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systolic Function ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Albino Rats ◽  
Acute Administration ◽  
Rat Hearts ◽  
Patients With Diabetes ◽  
Streptozotocin Induced Diabetes ◽  
Wistar Albino Rats

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.

scholarly journals Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats

2015 ◽  
Vol 35 (4) ◽  
pp. 1326-1334 ◽  
Author(s):  
Saritha Marella ◽  
Dilip Rajasekhar Maddirela ◽  
Kameswara Rao Badri ◽  
Malaka Venkateshwarulu Jyothi Kumar ◽  
Apparao Chippada
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Protective Effects ◽  
Tissue Lipid ◽  
Lipid Levels ◽  
Liver And Kidney ◽  
Streptozotocin Induced Diabetes ◽  
Wistar Albino Rats

Background: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic “Mcy protein” isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. Materials and Methods: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. Results: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats. Conclusion: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.

scholarly journals Amelioration of Cell Phone and Wi Fi induced Pancreatic Damage and Hyperglycemia (Diabetes Mellitus) with Pomegranate and Vit E in Rats

2021 ◽  
pp. 204-215
Author(s):  
Hadiya Sibghatullah ◽  
Sibghatullah Muhammad Ali Sangi ◽  
Elsamoual Ibrahim Ahmedani ◽  
Ali Alqahtani ◽  
Abdulhakim Bawadekji ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ionizing Radiation ◽  
Cell Phone ◽  
Histopathological Examination ◽  
Cell Damage ◽  
Cell Phones ◽  
Albino Rats ◽  
Pancreatic Cell ◽  
Rat Pancreas ◽  
Wistar Albino Rats

Background: Type 2 Diabetes Mellitus has become a global concern. To date numerous studies have been conducted but little literature is available to explain the effects of mobile phone radiation on pancreas, where from Insulin is secreted. In Some studies, effects of ionizing radiation have been examined and established the relationship between cell phone exposure and cell damage. Objectives: Objectives of study were to observe the effects of mobile phones, connected with WiFi on the pancreas. Methods: 40 male Wistar Albino rats were exposed tomobile phones connected with Wi-Fi for eight weeks. Results: The histopathological examination of the rat pancreas revealed that, exposure of rats to cell phones and Wi-Fi causes significant damage to the rat pancreas. Conclusion: The ionizing radiation emitted from cell phones and WiFi causes increase in oxidative stress leading to inflammation and pancreatic cell death that may affect glucose homeostasis.

scholarly journals Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes

2016 ◽  
Vol 19 (6) ◽  
pp. 464-470 ◽  
Author(s):  
Amel Mahmoud Soliman ◽  
Ayman Saber Mohamed ◽  
Mohamed-Assem Said Marie
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Diabetic Complication ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Wistar Albino Rats

Background. The main complication of diabetes mellitus is diabetic nephropathy in both types, which is a main reason for renal failure. Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progression of diabetic complication in kidney.Materials and methods. Thirty-six male Wistar albino rats were divided into two main groups, type 1 diabetes mellitus and type 2 diabetes mellitus. Both groups divided into control, diabetic and echinochrome subgroups. Type 1 diabetes was induced by single dose of streptozotocin (60 mg/kg, i.p), while type 2 was induced by high fat diet for 4 weeks before the injection with streptozotocin (30 mg/kg, i.p). The treated groups were administrated by echinochrome (1mg/kg body weight in 10% DMSO) daily for 4 weeks.Results. Echinochrome groups showed reduction in the concentrations of glucose, malondialdehyde, urea, uric acid and creatinine. While it caused general increase in glutathione-S-transferase, superoxide dismutase, catalase, glutathione reduced, nitric oxide and creatinine clearance. The histopathological investigation showed clear improvement in the kidney architecture.Conclusion. Administration of echinochrome improves renal function and ameliorates renal histopathological changes possibly by improvement of glucose metabolism and inhibition of lipid peroxidation process.

scholarly journals Effect of Pedalium murex Dry Seed Extract on Testicular Dysfunction in Streptozocin Induced Diabetes Mellitus in Wistar Albino Rats

2017 ◽  
Vol 10 (3) ◽  
pp. 1507-1515 ◽  
Author(s):  
Panigrahy Ankita ◽  
Behera Jayanti Prava ◽  
Priyadarshi Kunal ◽  
Maharana Chandra Sekhar
Keyword(s):  
Diabetes Mellitus ◽  
Seed Extract ◽  
Albino Rats ◽  
Testicular Dysfunction ◽  
Pedalium Murex ◽  
Wistar Albino Rats

scholarly journals Antidiabetic effect of 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon on Alloxan induced rats

2020 ◽  
Vol 11 (4) ◽  
pp. 7425-7428
Author(s):  
Vurimi Bhopal Chandra ◽  
Kudagi B L ◽  
Madhavulu Buchineni ◽  
Pathapati Rama Mohan ◽  
Anjani Devi Nelavala
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Average Weight ◽  
Free Access ◽  
High Blood Glucose ◽  
Sugar Levels ◽  
Wistar Albino Rats

Diabetes Mellitus is known as a syndrome, a collection of disorders with high blood glucose level & glucose intolerance as its feature, either because of insulin deficiency or insulin impairment or both. Diabetes Mellitus, based on insulin, is broadly classified into two types. Type one indicates the distraction of pancreatic β - cells that leads to diabetes mellitus, in which insulin is necessary to prevent ketoacidosis, coma, death. Type two diabetes is characterized by disorders of insulin resistance & secretion. Male Wistar albino rats with an average weight of 180-250 g were used in this study. With a 12 hours’ light and dark period, they were kept under normal conditions (room temperature 24-27oC and humidity 60-65 %). The free access of drinking water & pellet diet to male Wistar albino rats was allowed, as per the CPCSEA guidelines. Anti-diabetic activity of Compound 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon, male Wistar albino rats were divided into four different groups. 1ml of blood samples were collected directly into anticoagulant bottles from the tail vein & later plasma was collected after centrifugation. Blood sugar levels were determined by spectrophotometer. There was a significant decrease in blood sugar levels in Alloxan + Glibenclamide and Alloxan + Compound groups on compared to control. The present self-funded study concludes that antidiabetic activity of 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon in Alloxan induced diabetic rats significantly shows decreed blood sugar levels when compared to the control group.

scholarly journals The effect of Leaf Salam Extracts (Syzygium polyanthum) in diabetes mellitus therapy on wistar albino rats

2019 ◽  
Vol 1246 ◽  
pp. 012034
Author(s):  
Nita Parisa ◽  
Nia Savitri Tamzil ◽  
Debby Handayati Harahap ◽  
Gita Dwi Prasasty ◽  
Rachmat Hidayat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Albino Rats ◽  
Wistar Albino Rats
Sign in / Sign up

Export Citation Format

Share Document