scholarly journals SYNTHESIS OF ISOXAZOLO AND PYRAZOLINO ANNELATED CARBAZOLES FROM 2-(3'-(2'-CHLORO) QUINOLIDINE)-1-OXO-1, 2, 3, 4-TETRAHYDROCARBAZOLE AND 2-CHLORO-3-FORMYLQUINOLINE

2015 ◽  
Vol 2 (1) ◽  
pp. 29-31
Author(s):  
Sangeetha V
Keyword(s):  
Hydrazine Hydrate ◽  
Aldol Condensation ◽  
Hydroxylamine Hydrochloride ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

1-Oxo-1,2,3,4-tetrahydrocarbazole (1) on mixed aldol condensation with 2-chloro-3-formylquinoline (2) ielded 2-(3'-(2'-chloro)quinolidine)-1-oxo-1,2,3,4-tetrahydrocarbazole (3), which was further treated with hydroxylamine hydrochloride and hydrazine hydrate in separate reactions to afford 4,5-dihydro-3-3'-(2'-chloro) quinoline -isoxazolo [3,4-a]carbazole (4) and 3'-(2'-chloro)- quinoline- 3,3a,4,5- tetrahydro- 2Hpyrazolino [3,4-a]carbazole (5). The prepared compounds were elaluated for their invitro antibacterial and antifungal activities against certain pathogenic fungal and bacterial strains.

scholarly journals In VitroPhytochemical, Antibacterial, and Antifungal Activities of Leaf, Stem, and Root Extracts ofAdiantum capillus veneris

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Muhammad Saqib Ishaq ◽  
Muhammad Medrar Hussain ◽  
Muhammad Siddique Afridi ◽  
Ghadir Ali ◽  
Mahrukh Khattak ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Antimicrobial Activities ◽  
Phytochemical Analysis ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
Fungal Strains ◽  
Antibacterial And Antifungal Activities ◽  
Adiantum Capillus Veneris ◽  
Ethanol Extracts ◽  
Antibacterial And Antifungal

Adiantum capillus venerisis a medicinally essential plant used for the treatment of diverse infectious diseases. The study of phytochemical and antimicrobial activities of the plant extracts against multidrug-resistant (MDR) bacteria and medically important fungi is of immense significance. Extracts from the leaves, stems, and roots ofAdiantum capillus veneriswere extracted with water, methanol, ethanol, ethyl acetate, and hexane and screened for their antimicrobial activity against ten MDR bacterial strains and five fungal strains isolated from clinical and water samples. Ash, moisture, and extractive values were determined according to standard protocols. FTIR (Fourier transform infrared Spectroscopy) studies were performed on different phytochemicals isolated from the extracts ofAdiantum capillus Veneris. Phytochemical analysis showed the presence of flavonoids, alkaloids, tannins, saponins, cardiac glycosides, terpenoids, steroids, and reducing sugars. Water, methanol, and ethanol extracts of leaves, stems, and roots showed significant antibacterial and antifungal activities against most of the MDR bacterial and fungal strains. This study concluded that extracts ofAdiantum capillus venerishave valuable phytochemicals and significant activities against most of the MDR bacterial strains and medically important fungal strains.

Infrared, 1H-NMR Spectral Studies of some Methyl 6-O-Myristoyl-α-D-Glucopyranoside Derivatives: Assessment of Antimicrobial Effects

2015 ◽  
Vol 58 ◽  
pp. 122-136 ◽  
Author(s):  
Sarkar M.A. Kawsar ◽  
Khaleda Mymona ◽  
Refat Asma ◽  
Mohammad A. Manchur ◽  
Yasuhiro Koide ◽  
...  
Keyword(s):  
Pathogenic Fungi ◽  
Spectral Studies ◽  
Bacterial Strains ◽  
Substitution Product ◽  
Antifungal Activities ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Fungal Phytopathogens ◽  
Antibacterial And Antifungal

This study was carried out to regioselective myristoylation of methyl α-D-glucopyranoside (1) using the direct acylation method gave the corresponding methyl 6-O-myristoyl-α-D-glucopyranoside (2) in fair yield. A number of 2,3,4-tri-O-acyl derivatives (3-15) of this 6-O-substitution product using a wide variety of acylating agents were also prepared in order to obtain newer derivatives of synthetic and biological importance. The reaction conditions are reasonably simple and yields were very good. The structures of the title compounds (2-15) were established by using analytical, physicochemical techniques and spectroscopic data (IR and 1H-NMR). All the synthesized compounds were employed as test chemicals for in vitro antimicrobial functionality test against Gram-positive Bacillus subtilis, Staphylococcus aureus, Gram-negative Escherichia coli, Pseudomonas aeruginosa bacteria and plant pathogenic fungi Aspergillus niger and Candida albicans. For comparative studies, antimicrobial activity of standard antibiotics, Ampicillin and Nystatin were also carried out against these microorganisms. The study revealed that the tested samples exhibited moderate to good antibacterial and antifungal activities. It was also observed that the test substances were more effective against fungal phytopathogens than those of the human bacterial strains. Encouragingly, a number of tested chemicals showed nearest antibacterial and antifungal activities with the standard antibiotics employed.

scholarly journals Comprehensive Evaluation of the Antibacterial and Antifungal Activities of Carlina acaulis L. Essential Oil and Its Nanoemulsion

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1451
Author(s):  
Antonio Rosato ◽  
Alexia Barbarossa ◽  
Ahmed M. Mustafa ◽  
Giulia Bonacucina ◽  
Diego Romano Perinelli ◽  
...  
Keyword(s):  
Essential Oil ◽  
Comprehensive Evaluation ◽  
Antimicrobial Properties ◽  
Homogenization Method ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
Fungal Strains ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
New Compounds

Plants are considered to be an excellent source of new compounds with antibiotic activity. Carlina acaulis L. is a medicinal plant whose essential oil (EO) is mainly characterized by the polyacetylene carlina oxide, which has antimicrobial properties. The aim of this study was to evaluate the antimicrobial and antifungal activities of C. acaulis EO, carlina oxide, and nanoemulsion (NE) containing the EO. The EO was obtained through plant roots hydrodistillation, and carlina oxide was purified from it through silica gel column chromatography. The NE containing C. acaulis EO was prepared with the high-pressure homogenization method, and the minimum inhibitory concentration (MIC) was determined against several bacterial and fungal strains for all the C. acaulis-derived products. The latter resulted in activity active versus all the screened Gram-positive bacterial strains and also on all the fungal strains with low MIC values. For yeast, the EO and carlina oxide showed good MIC values. The EO-NE demonstrated a better activity than the pure EO on all the tested bacterial and fungal strains. The results suggest that C. acaulis-derived products could be potential candidates for the development of natural antibacterial and antifungal agents.

Sequential multicomponent catalytic synthesis of pyrrole-3-carboxaldehydes: evaluation of antibacterial and antifungal activities along with docking studies

2020 ◽  
Vol 44 (38) ◽  
pp. 16329-16339
Author(s):  
Nisar A. Mir ◽  
Panduga Ramaraju ◽  
Satheeshvarma Vanaparthi ◽  
Sachin Choudhary ◽  
Rajnish P. Singh ◽  
...  
Keyword(s):  
Docking Studies ◽  
Catalytic Synthesis ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

A sequential multicomponent method is developed to access highly substituted N-arylpyrrole-3-carbaldehydes and tested for antibacterial and antifungal activities against bacterial strains.

scholarly journals Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Antibacterial and Antifungal Activities

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
A. Bushra Begum ◽  
Noor Fatima Khanum ◽  
V. Lakshmi Ranganatha ◽  
T. Prashanth ◽  
Mohammed Al-Ghorbani ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Human Beings ◽  
Bacterial Strains ◽  
Chemical Methods ◽  
Subtle Change ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Paratyphi B ◽  
Antibacterial And Antifungal ◽  
Microbiological Assays

Microorganisms are closely associated with the health and welfare of human beings. Whereas some microorganisms are beneficial, others are detrimental. Bacterial infections often produce inflammation and pains and in some instances, infections result in high mortality. Any subtle change in the drug molecule, which may not be detected by chemical methods, can be revealed by a change in the antimicrobial activity and hence microbiological assays are very useful. A series of substituted hydroxy benzophenones and benzophenone-N-ethyl morpholine ethers were screened for their antibacterial and antifungal activities. Antibacterial activity againstS. aureus,E. aerogenes,M. luteus,K. pneumonia, andS. typhimurium,S. paratyphi-BandP. vulgarisbacterial strains and antifungal activity againstC. albicans,B. cinerea,M. pachydermatis,C. kruseifungal strains were carried out. The bioassays indicated that most of the synthesized compounds showed potential antibacterial and antifungal agents.

scholarly journals Synthesis and antimicrobial evaluation of some 1-(4-arylthiazol-2-yl)-1′-(aryl/heteroaryl)-3,3′-dimethyl-[4,5′-bi-1H-pyrazol]-5-ols

2017 ◽  
Vol 82 (2) ◽  
pp. 127-139 ◽  
Author(s):  
Satbir Mor ◽  
Rajni Mohil ◽  
Savita Nagoria ◽  
Ashwani Kumar
Keyword(s):  
Antibacterial Activities ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
Docking Simulations ◽  
Antibacterial And Antifungal Activities ◽  
Dehydroacetic Acid ◽  
Antimicrobial Evaluation ◽  
High Yields ◽  
Antibacterial And Antifungal

A series of sixteen 1-(4-arylthiazol-2-yl)-1?-(aryl/heteroaryl)-3,3?-dimethyl-[ 4,5?-bi-1H-pyrazol]-5-ols (7a?p) was synthesized starting from dehydroacetic acid (DHA, 1) via the stepwise formation of thiosemicarbazone (2), 3-(1-(2-(4-arylthiazol-2-yl)hydrazono)ethyl)-4-hydroxy-6-methyl-2H-pyran- -2-ones (4a?d) and 1-(1-(4-arylthiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol- -4-yl)butane-1,3-diones (5a?d) in high yields. The in vitro antibacterial and antifungal activities of the synthesized bipyrazoles 7a?p were investigated against two Gram-positive bacterial strains, viz. Bacillus subtilis (MTCC 441) and Staphylococcus aureus (MTCC 7443), one Gram-negative bacterial strain, viz. Escherichia coli (MTCC 42), and two fungal strains, viz. Candida albicans (MTCC 183) and Aspergillus niger (MTCC 282). The compounds 7a and 7e were found to exhibit better inhibitory activity against A. niger than the reference fluconazole. Moreover, the antifungal activities of the title compounds were more prolific than their antibacterial activities. Furthermore, in order to study binding interactions, docking simulations of compounds 7a, 7m and 7o were performed into the active site of S. aureus 1,4-dihydroxy-2-naphthoyl- -CoA synthase. Keywords: bipyrazoles; antibacterial; antifungal; docking simulations.

scholarly journals Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one

2010 ◽  
Vol 7 (2) ◽  
pp. 383-390 ◽  
Author(s):  
B. Lakshminarayanan ◽  
V. Rajamanickam ◽  
T. Subburaju ◽  
L. A. Pradeep Rajkumar
Keyword(s):  
Antimicrobial Activity ◽  
Sodium Hydroxide ◽  
Hydrazine Hydrate ◽  
Water Bath ◽  
Plate Method ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Amino Compounds ◽  
Antibacterial And Antifungal

The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

scholarly journals Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Muhammad Abdul Qadir ◽  
Mahmood Ahmed ◽  
Hina Aslam ◽  
Sadia Waseem ◽  
Muhammad Imtiaz Shafiq
Keyword(s):  
Spectral Analysis ◽  
New Products ◽  
Biological Evaluation ◽  
Bacterial Strains ◽  
Antifungal Activities ◽  
E Coli ◽  
Antibacterial And Antifungal Activities ◽  
Ft Ir ◽  
Antibacterial And Antifungal

New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS,1HNMR, and13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely,S. aureus, B. subtilis, andE. coli, and fungi, namely,A. flavus, A. parasiticus, andA.sp. The antibacterial and antifungal activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds3b,9a, and9bhave most potent activity againstS. aureus, A. flavus, and A. parasiticus, respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 μg/mL. In contrast, all the compounds were totally inactive against theA.sp. except10band15bto show activity to some extent.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential Oil from Flowers of Eryngium triquetrum (Apiaceae) Collected Wild in Sicily

2016 ◽  
Vol 11 (7) ◽  
pp. 1934578X1601100
Author(s):  
Simona Casiglia ◽  
Maurizio Bruno ◽  
Sergio Rosselli ◽  
Felice Senatore
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Art Works ◽  
Main Components ◽  
Antibacterial And Antifungal ◽  
Historical Art

The chemical composition of the essential oil from flowers of Eringium triquetrum Vahl. collected in Sicily was evaluated by GC and GC-MS. The main components were pulegone (50.6%), piperitenone (30.5%) and menthone (7.0%). Comparison of this oil with other studied oils of Eringium species is discussed. The oil showed good antibacterial and antifungal activities against some microorganisms that infest historical art works.

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