scholarly journals SYNTHESIS, CHARACTERISATION, THERMAL ANALYSIS AND DNA CLEAVAGE ACTIVITY OF COPPER PYRAZOLE SCHIFF BASE

2018 ◽  
Vol 5 (1) ◽  
pp. 23-27
Author(s):  
Jayanthi E ◽  
Anusuya M
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Acid Hydrazide ◽  
Single Step ◽  
Cleavage Activity ◽  
Imine Nitrogen ◽  
Dna Cleavage Activity ◽  
Bidentate Chelate ◽  
Ft Ir

Thiophene-2-carboxylic acid hydrazide and 1, 3-diphenyl-1H-pyrazole-4-carboxaldehyde reacted together in 1:1 mole ratio to form Schiff base ligand(L) which was subsequently, reacted with CUCl2.2H2 Oformed complex of the composition (Cu(L)Cl2). The Schiff base ligand and its Cu(II) complex were characterized on the basis of elemental analysis,thermogravimetry, UV-Visible spectroscopy, FT-IR spectroscopy and NMR spectroscopy. IR spectrum of the copper complex shows that the ligand coordinated through imine nitrogen and amide oxygen atom forming a neutral bidentate chelate with the metal centre.The thermal behaviour of thecomplex shows a single step decomposition pattern leaving CuO residues.DNA cleavage activity of the complexshowed the potential of the complex to cleave supercoiled DNA.

scholarly journals SYNTHESIS, CHARACTERISATION, THERMAL ANALYSIS AND DNA CLEAVAGE ACTIVITY OF A NOVELZINC (II) COMPLEX OF PYRAZOLE SCHIFF BASES

2018 ◽  
Vol 5 (2) ◽  
pp. 19-23
Author(s):  
Jayanthi Eswaran
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Acid Hydrazide ◽  
Single Step ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Shiff Base ◽  
Ft Ir

A hydrazone Schiff base Zn(II) metal complex is synthesised from the Shiff base ligand Thiophene-2-carboxylic acid hydrazide and 1, 3-diphenyl-1H-pyrazole-4-carboxaldehyde reacted together in 1:1 mole ratio to obtain Schiff base ligand (HL) which was subsequently, allowed to react with Zn(CH3COO)2.2H2O. The Schiff base ligand and its Zn (II) complex prepared were characterized on the basis of elemental nalysis,thermogravimetry, UV-Visible spectroscopy, FT-IR spectroscopy and NMR spectroscopy. IR spectrum of the zinc complex shows that the ligand (HL) is coordinated to the metal ion in monoanionicbidentate fashion with the 1:2 metal to ligand stoichiometry. The thermal behaviour of thecomplex shows a single step decomposition pattern leaving the respective ZnO residue. The DNA cleavage activity of the complex ismonitored using agarose gel lectrophoresis method which indicates the potential of the complex to cleave supercoiled DNA.

Photocytotoxicity and DNA cleavage activity of l-arg and l-lys Schiff base oxovanadium(iv) complexes having phenanthroline bases

2010 ◽  
Vol 39 (30) ◽  
pp. 7104 ◽  
Author(s):  
Pijus K. Sasmal ◽  
Ritankar Majumdar ◽  
Rajan R. Dighe ◽  
Akhil R. Chakravarty
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Phenanthroline Bases

Syntheses, structures and DNA cleavage activity of NNO-tridentate Schiff base copper complexes

Polyhedron ◽  
2012 ◽  
Vol 45 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Bao-Tsan Ko ◽  
Chia-Chih Chang ◽  
Shu-Ling Lai ◽  
Fun-Jie Lai ◽  
Chu-Chieh Lin
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Copper Complexes ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Tridentate Schiff Base

scholarly journals Syntheses, Characterization, Antimicrobial and DNA Cleavage Activity of Cr(III) Complexes with Coumarin based Schiff Base Ligands

2021 ◽  
Vol 33 (12) ◽  
pp. 2983-2988
Author(s):  
Ramhari Meena ◽  
Anita Kumari ◽  
Naveen Sharma ◽  
Nighat Fahmi
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Biological Activities ◽  
Spectroscopic Techniques ◽  
Molecular Weight Determination ◽  
Central Metal ◽  
Schiff Base Ligands ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

A series of biologically important complexes of chromium(III) have been synthesized by the reaction of 3-formyl-4-chlorocoumarin hydrazinecarbothioamide (L1H) and 3-formyl-4-chlorocoumarin hydrazinecarboxamide (L2H) with CrCl3·6H2O in 1:1 and 1:2 molar ratio. All the complexes have been characterized by elemental analysis, molecular weight determination, melting point, conductivity measurements, electronic, IR, 1H NMR, 13C NMR and EPR spectroscopic techniques and X-ray diffraction. In vitro biological screening effects of the compounds were tested against the pathogenic bacterial and fungal species. Further, free ligands and their metal complexes have been screened for their DNA cleavage activity. A comparative study of the biological activities of the Schiff base ligands and their Cr(III) complexes indicates that the complexes exhibit higher antimicrobial and DNA cleavage activity than the free ligands. Physico-chemical studies and spectral data suggested a hexa-coordinated environment around the central metal ion.

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