Diagnostic Precision of C-Reactive Protein Levels, Neutrophil Count and Total Leukocyte Count in Identifying Acute Appendicitis Clinically

Introduction. Colorectal cancer is the third most common cancer worldwide. The introduction of novel diagnostic and treatment methods has resulted in decreasing mortality rates; however, an increase in morbidity is observed. Severe inflammation plays an important role in many aspects associated with carcinogenesis. Neoplasia and inflammatory response are mutually related. Aim. The aim of the study was to evaluate the association between preoperative serum C-reactive protein levels and total leukocyte count in colorectal cancer patients in comparison with postoperative histopathological findings depending on whether there was neoplastic infiltration of the local adipose tissue or not. Material and methods. The study population included 50 patients with colon cancer. Exclusion criteria were distant metastases, neoadjuvant therapy and a past history of cancer diagnosis. Blood findings were compared with histopathology. Patients were divided into two groups – with and without neoplastic infiltration of fat tissue in histopathology. Results. Serum C-reactive protein levels were evaluated in all patients. The tested indicator was higher in the group with infiltration, but was not statistically significant. Additionally, the WBC count was normal in both groups, but it was lower in the group with infiltration, and the result was statistically significant. Conclusions. C-reactive protein level and total leukocyte count can be a helpful and supportive marker in staging in colorectal cancer patients. Owing to the wide availability and low cost of the above mentioned blood tests, they may be easily performed in daily medical practice. The decrease in the total leukocyte count was proportional with higher cancer stage; therefore, it needs to be further investigated.

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Role of total leukocyte count and C-reactive protein in diagnosis of acute appendicitis

International Surgery Journal ◽

10.18203/2349-2902.isj20180446 ◽

2018 ◽

Vol 5 (3) ◽

pp. 883

Author(s):

Anuradha Dnyanmote ◽

Sagar Ramesh Ambre ◽

Foram Doshi ◽

Snehal Ambre

Keyword(s):

Acute Appendicitis ◽

Sensitivity And Specificity ◽

Leukocyte Count ◽

Total Leukocyte Count ◽

C Reactive Protein ◽

Reactive Protein ◽

Surgical Emergencies ◽

Group A ◽

Negative Appendicectomy ◽

Group B

Background: Acute appendicitis is still one of the most common surgical emergencies. This study was conducted to check the sensitivity and specificity of Total leukocyte count (TLC) and C Reactive Protein (CRP) of acute appendicitis. Aim and objectives were to check the sensitivity and specificity of total leukocyte count in diagnosis of acute appendicitis and to check the sensitivity and specificity of CRP in diagnosis of acute appendicitis. To determine TLC and CRP efficacy in diagnosis of acute appendicitis.Methods: TLC and CRP were calculated in all patients who were planned to undergo appendectomy. Appendectomies were performed independent of results of TLC and CRP levels. For statistical purpose the patients were assigned into 2 groups- Group-A Patients with inflamed/perforated/gangrenous appendix, Group-B patients with Normal appendix. The normal TLC and CRP values, raised TLC, raised CRP, and raised both TLC and CRP values calculated in each of these groups. Sensitivity and Specificity were calculated. The cut off value for TLC was 11x106/L. This value was selected arbitrarily as it corresponds to the elevated TLC. The CRP levels were calculated and cut off value was taken as 1.7mg/dl.Results: Out of 75 cases, 55 were male and 20 were female. Age ranged from 13 to 58 years. CRP was raised in 82.14% of inflamed appendix cases TLC was raised in 76.79% of inflamed appendix cases and both was raised in 92.5% of inflamed appendix cases.Conclusions: TLC and CRP are useful in diagnosis of acute appendicitis. Negative appendicectomy rate can be decreased.

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Utility of Blood Markers in Early Prediction of Bacteraemia in Acute Febrile Paediatric Patients – An Observational Cohort Study in a Tertiary Care Hospital of North India

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/467 ◽

2021 ◽

Vol 8 (28) ◽

pp. 2526-2531

Author(s):

Rabindra Bhunia ◽

Bindu T. Nair ◽

Vandana Negi

Keyword(s):

Tertiary Care Hospital ◽

Leukocyte Count ◽

Tertiary Care ◽

North India ◽

Total Leukocyte Count ◽

Care Hospital ◽

C Reactive Protein ◽

Reactive Protein ◽

Neutrophil Percentage ◽

Observational Cohort

BACKGROUND Bacteraemia is a common cause of children presenting to the paediatric emergency with acute febrile illness. Blood cultures remain the gold standard for detection of bacteraemia but the positivity is low and also takes time to show positive results. A rapid and reliable biomarker like procalcitonin (PCT), C-reactive protein (CRP), total leucocyte count (TLC), and neutrophil-lymphocyte count ratio (NLCR) can be used to identify febrile children with greater risk for bacteraemia or serious bacterial infections. This would be very helpful to start early treatment of bacteraemia with antibiotics. METHODS The study was an observational cohort study conducted in the Department of Paediatrics of a tertiary care hospital in North India in children between age group 6 months to 12 years presenting with fever of > 100.4° F for 2 - 7 days. Blood samples were sent for PCT, CRP, TLC, NLCR and blood cultures. RESULTS The most sensitive biomarker was total leukocyte count (47.36 %) followed by the neutrophil percentage (26.32 %), C-reactive protein (21.05 %), and procalcitonin (15.79 %). The most specific biomarker was procalcitonin (75.14 %) followed by C-reactive protein (58.56 %), neutrophil percentage (22.65 %) and total leukocyte count (11.05 %). The only biomarker that was statistically significant between the bacteraemia and non-bacteraemia group in the present study was total leukocyte count (P – value < 0.05). CONCLUSIONS The sensitivity and specificity of each single biomarker is low and hence these cannot be used singly to predict bacteraemia. There should be a combination of biomarkers with adequate sensitivity and specificity that can be used to create an algorithm to aid in diagnosis and prognostication. KEYWORDS Procalcitonin, C-Reactive Protein, Blood Culture, Acute Febrile Patient

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Total leucocyte count, C-reactive protein and neutrophil count: Diagnostic Aid in acute appendicitis

Saudi Journal of Gastroenterology ◽

10.4103/1319-3767.48969 ◽

2009 ◽

Vol 15 (2) ◽

pp. 117 ◽

Cited By ~ 17

Author(s):

SheikhMuzamil Shafi ◽

Misbha Afsheen ◽

FarooqA Reshi

Keyword(s):

Acute Appendicitis ◽

Neutrophil Count ◽

Leucocyte Count ◽

Total Leucocyte Count ◽

C Reactive Protein ◽

Diagnostic Aid ◽

Reactive Protein

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Comparison of C-reactive protein levels, neutrophil count, and clinical outcomes between low-dose ketamine given at the end of surgery and at induction in laparotomy

Bali Journal of Anesthesiology ◽

10.4103/bjoa.bjoa_248_20 ◽

2021 ◽

Vol 5 (2) ◽

pp. 98

Author(s):

MadeSeptyana Parama Adi ◽

IMade Gede Widnyana ◽

IPutu Pramana Suarjaya ◽

TjokordaGde Agung Senapathi ◽

Christopher Ryalino

Keyword(s):

Clinical Outcomes ◽

Neutrophil Count ◽

Low Dose ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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Serum resistin: A possible link between inflammation, hypertension and coronary artery disease

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.3.274 ◽

2019 ◽

Vol 35 (3) ◽

Cited By ~ 2

Author(s):

Sobia Niaz ◽

Javaria Latif ◽

Shaista Hussain

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Angina Pectoris ◽

Leukocyte Count ◽

Total Leukocyte Count ◽

C Reactive Protein ◽

Hypertensive Patients ◽

Reactive Protein ◽

Artery Disease

Background & Objectives: Inflammation is considered as the main triggering factor in evolution of atherosclerotic pathology of heart and blood vessels. Resistin, an inflammatory cytokine is proved to be a main mediator of initiation and progression of mechanisms leading to atherosclerosis, hypertension and ultimately to coronary artery disease. Our objective was to compare the levels of serum resistin, C-reactive protein and total leucocyte count in subjects of hypertension and coronary artery disease; and to observe the correlation of serum resistin with CRP and TLC in the study participants. Methods: Eighty selected participants were divided into four equal groups including normal healthy participants, newly diagnosed cases of hypertension, stable angina pectoris and myocardial infarction, both with hypertension. The study was conducted in the physiology department of Post Graduate Medical Institute Lahore, during 2013. After consent, history and examination, fasting blood samples of the participants were collected. Serum resistin and C-reactive protein were determined by using standard techniques of enzyme linked immunosorbent assay, while total leukocyte count by automated hematology analyzer. Results: The values of serum resistin, C- reactive protein and total leukocyte count were found significantly raised in patients of hypertension, angina pectoris and myocardial infarction with hypertension as compared to normal participants (p<0.001 for all). Significantly positive correlation of resistin was observed with TLC only in hypertensive patients of myocardial infarction (r = 0.459, n = 20, p = 0.042) while in other study groups correlation between resistin and TLC as well as CRP was non-significant. Conclusion: Serum resistin levels along with CRP and TLC are significantly raised in patients of hypertension and coronary artery disease while resistin levels revealed significantly positive correlation with TLC in hypertensive patients of myocardial infarction. doi: https://doi.org/10.12669/pjms.35.3.274 How to cite this:Niaz S, Latif J, Hussain S. Serum resistin: A possible link between inflammation, hypertension and coronary artery disease. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.274 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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