scholarly journals Assessment of C-reactive Protein, Lipid Profile and Body Mass Index in Type2 Diabetes Mellitus in Sudanese Patients

2021 ◽  
Vol 04 (02) ◽  
Author(s):  
Alhussein Alsayed Mukhtar Garrashy ◽  
Omer Fudal Idris ◽  
Mustafa Salimeen ◽  
Ibrahim Eltirafi
Author(s):  
Ghada A Elfadil ◽  
Abdelgadir Elmugadam ◽  
Rasheeda A Saied ◽  
Salah Omar Hussein

Introduction: An increased Body Mass Index (BMI) has an adverse effect on the socio-economic and healthcare sectors and may influence metabolic status. High sensitivity C-reactive Protein (hs-CRP) is an emerging biomarker. The association between dyslipidaemia and obesity is well established, and has been found to be the risk factors for CVD. Aim: To study the relationship of hs-CRP with BMI, lipid profile and magnesium among obese and overweight non-diabetic non-hypertensive Sudanese women. Materials and Methods: A cross-sectional study was conducted on 90 women in Khartoum state (Sudan), aged between 20 and 43 years, from June to November 2019. The study included three groups of women based on BMI. hs-CRP was measured by using latex immunoturbidimetric method, lipid profile was evaluated using Biosystems colourimetric methods and magnesium by a chemical method. Results were computed using Statistical Package for the Social Sciences (SPSS) version 20.Results: There was significant increase in the mean values of hs-CRP, Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-C), and a significant decrease in the mean values of High Density Lipoprotein Cholesterol (HDL-C) and magnesium in obese and overweight women, when compared to normal body weight women. Pearson’s correlation coefficient revealed a positive correlation between hs-CRP, and BMI, Waist-To-Hip Ratio (WHR), TC, TG, and LDL-C (p-value <0.01). Conclusion: Overweight and obese women have increased hs-CRP and atherogenic lipid profile, suggesting obesity to be a state of chronic inflammation. hs-CRP can be used to assess the risk of obesity-related disorders for early intervention.


2013 ◽  
Vol 20 (2) ◽  
pp. 127-133
Author(s):  
Valeria Mocanu ◽  
Romulus Timar ◽  
Raluca Horhat ◽  
Adina Bucur ◽  
Viorel Şerban

AbstractBackground and aims: C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR). The body mass index (BMI) is an important element, frequently evaluated in patients with diabetes mellitus. The purpose of this study was to determine the relationship between CRP, BMI and existing DR in type 2 diabetes (T2DM) subjects. Material and method: Thirty T2DM patients aged 35-50 were subjected to a general, ophthalmologic and fundus examination. Results: 9 of the 30 patients (30%) didn’t presented changes in the fundus examination. 15 (50%) presented minor retinal changes while 6 (20%) were diagnosed with DR: one case of nonproliferative diabetic retinopathy, 2 cases of preproliferative DR and 3 cases of proliferative DR. In patients with normal fundus examination and minor retinal changes, CRP was positive in the majority of the cases (95.8%). CRP was positive in only one patient in the group with diagnosed DR. BMI was increased in 85.71% of the patients with retinal changes: angiosclerosis or DR and in only 22.22% of the patients without retinal changes. Conclusions: Lower CRP and higher BMI were associated with higher prevalence of DR.


2003 ◽  
Vol 35 (7) ◽  
pp. 1160-1166 ◽  
Author(s):  
ERIC S. RAWSON ◽  
PATTY S. FREEDSON ◽  
STAVROULA K. OSGANIAN ◽  
CHARLES E. MATTHEWS ◽  
GEORGE REED ◽  
...  

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