scholarly journals Biosynthesis, occurrence and characterization of gla-containing proteins with a potential importance for cardiovascular diseases

1989 ◽  
Author(s):  
L.E.M. de Haarlem
2018 ◽  
Vol 161 ◽  
pp. 133-143 ◽  
Author(s):  
Muhammad Adam ◽  
Shu Lih Oh ◽  
Vidya K Sudarshan ◽  
Joel EW Koh ◽  
Yuki Hagiwara ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Luiza Gabriela de Araújo Fonseca ◽  
Illia Nadinne Dantas Florentino Lima ◽  
Lucien Peroni Gualdi

2014 ◽  
Vol 168 (5) ◽  
pp. 759-762
Author(s):  
Chandran Ka ◽  
Jian-Min Chen ◽  
Isabelle Gourlaouen ◽  
Sylvia Quemener ◽  
Christophe Ronsin ◽  
...  
Keyword(s):  

Author(s):  
Filipa Carneiro ◽  
Ana E. Silva ◽  
Senhorinha F. C. F. Teixeira ◽  
Jose´ C. F. Teixeira ◽  
Pedro A. M. Lobarinhas ◽  
...  

The characterization of blood flow is important to establish links between the hemodynamics and the occurrence of cardiovascular diseases. This study describes the development of a 3-D computational model able to predict the blood flow along the abdominal aorta, including the renal and iliac branches. Upstream branches in the abdominal aorta lead to more complex flow patterns downstream, intensifying reverse and asymmetric flow patterns. The focus is on the occurrence of reverse flow and the perturbations in blood flow patterns originated by the branches. Results show regions of recirculation in the walls of the abdominal aorta, renal and iliac branches. It is concluded that, the renal branches induces perturbations in blood flow and result in asymmetric velocity profiles.


Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 843 ◽  
Author(s):  
Alice Mallia ◽  
Erica Gianazza ◽  
Beatrice Zoanni ◽  
Maura Brioschi ◽  
Silvia Stella Barbieri ◽  
...  

Extracellular vesicles (EVs) are lipid-bound vesicles released from cells under physiological and pathological conditions. Basing on biogenesis, dimension, content and route of secretion, they can be classified into exosomes, microvesicles (MVs) and apoptotic bodies. EVs have a key role as bioactive mediators in intercellular communication, but they are also involved in other physiological processes like immune response, blood coagulation, and tissue repair. The interest in studying EVs has increased over the years due to their involvement in several diseases, such as cardiovascular diseases (CVDs), and their potential role as biomarkers in diagnosis, therapy, and in drug delivery system development. Nowadays, the improvement of mass spectrometry (MS)-based techniques allows the characterization of the EV protein composition to deeply understand their role in several diseases. In this review, a critical overview is provided on the EV’s origin and physical properties, as well as their emerging functional role in both physiological and disease conditions, focusing attention on the role of exosomes in CVDs. The most important cardiac exosome proteomic studies will be discussed giving a qualitative and quantitative characterization of the exosomal proteins that could be used in future as new potential diagnostic markers or targets for specific therapies.


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