scholarly journals Evaluation of the effectiveness of using platelet rich fibrin (PRF) as a sole grafting material and membrane in augmentation of dehiscence and fenestration defects encountered during dental implant surgery

2019 ◽  
Vol 31 (2) ◽  
pp. 44-51
Author(s):  
Ahmed M. Abbas ◽  
Salwan Y. Bede ◽  
Shefaa H. Alnumay
Keyword(s):  
Bone Regeneration ◽  
Primary Stability ◽  
Prospective Clinical Study ◽  
Graft Material ◽  
Implant Stability ◽  
Platelet Rich Fibrin ◽  
Significant Difference ◽  
The Mean ◽  
Dental Implant Surgery ◽  
Secondary Stability

Background: Bone regeneration in dehiscence and fenestration defect can be improved with the use of platelet rich fibrin (PRF) that provides a scaffold for new bone regeneration. This study was conducted to assess the effectiveness of PRF as a graft material and membrane in dehiscence and fenestration defects. Materials and Methods: This prospective clinical study included patients who received dental implants that demonstrated peri-implant defects which were augmented using Leukocyte- PRF (L-PRF) or Advanced-PRF (A-PRF). Twenty four weeks postoperatively the defect resolution and the density of regenerated bone were assessed by CBCT and re-entry surgery. The assessment also included measurement of primary and secondary implant stability using Periotest® M, success rate and complication rate of the installed implants. Results: The mean overall intraoperative defect size was 29.44 (± 14.1) mm2, postoperatively it became 2.07 (± 3.6) mm2 with a statistically significant difference (p= < 0.0001). There was no significant difference between L-PRF and A-PRF. Defect resolution ranged from 80% to 100% with a mean of 95.7% (± 6.7%). Defects that showed complete resolution were significantly smaller in size (21.2± 7 mm2) than those that showed partial resolution (44.4± 11 mm2). The overall mean primary stability recorded was 2.9 (± 1.6) Periotest values (PTV) and overall mean secondary stability was -0.22 (±1.4) (P<0.0001).The overall mean HU of the newly formed peri-implant bone was 385.7 (± 77.4). Conclusions: PRF as the sole graft material for peri-implant defects results in complete defect resolution in small to moderate defects, larger defects may require the addition of bone substitute to achieve complete defect resolution.

scholarly journals Effects of Platelet-Rich Fibrin on Hard Tissue Healing: A Histomorphometric Crossover Trial in Sheep

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1695
Author(s):  
Esra Ondur ◽  
Nilufer Bolukbasi Balcioglu ◽  
Merva Soluk Tekkesin ◽  
Ozlem Guzel ◽  
Selim Ersanli
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Graft Material ◽  
Hard Tissue ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Significant Difference ◽  
Time Point

Bone defects lead to aesthetic and functional losses, causing dental rehabilitation to be more difficult. The objective of this work is to histologically assess the hard tissue healing of bone defects filled with platelet-rich fibrin (PRF) alone or as an adjuvant for mixing with and covering anorganic bovine bone (ABB), compared to ABB covered with a resorbable collagen membrane (CM). This study was designed as a crossover animal study. Four 5-mm tibia defects, 5 mm apart from each other, were surgically created on the tibias of 6 sheep. The defects were randomly filled with ABB + CM; PRF alone; ABB+PRF; or were left empty. The animals were euthanized on days 10, 20, and 40 post-operatively. No group showed any signs of bone necrosis. Inflammation was observed in 2 control and 3 test defects with no statistically significant difference between groups at each time point. The ABB + CM and ABB + PRF groups experienced the highest bone regeneration ratios. No differences between the empty-defect and PRF groups were observed in regard to bone regeneration. No statistical difference was observed between the ABB+PRF and ABB + CM groups in regard to bone regeneration and the amount of residual graft material at each time point. The use of PRF should be preferred due to its autogenous origin, low cost, and ease of use.

scholarly journals The Effect of Recipient Jaw and Implant Dimensions on Pre- and Post- Loading Dental Implant Stability: A Prospective Clinical Study

2021 ◽  
Vol 33 (4) ◽  
pp. 31-37
Author(s):  
Dhuha A Al-Assaf ◽  
Salwan Y Bede
Keyword(s):  
Dental Implant ◽  
Primary Stability ◽  
Prospective Clinical Study ◽  
Implant Stability ◽  
Significant Difference ◽  
Rest Time ◽  
Age Range ◽  
Implant Length ◽  
Functional Loading

Background: Implant stability is a mandatory factor for dental implant (DI) osseointegration and long-term success. The aim of this study was to evaluate the effect of implant length, diameter, and recipient jaw on the pre- and post-functional loading stability. Materials and methods: This study included 17 healthy patients with an age range of 24-61 years. Twenty-two DI were inserted into healed extraction sockets to replace missing tooth/ teeth in premolar and molar regions in upper and lower jaws. Implant stability was measured for each implant and was recorded as implant stability quotient (ISQ) immediately (ISQ0), and at 8 (ISQ8) and 12 (ISQ12) weeks postoperatively, as well as post-functional loading (ISQPFL). The pattern of implant stability changes throughout the study period and its correlation with the recipient jaw and the DI dimensions were evaluated. Results: There was a significant difference in ISQ values throughout the study. DI stability in the maxilla was significantly higher than that in mandible for the ISQ0, with no significant effect for the rest time points. The effect of implant diameter was significant with DI of 4.1mm diameter being more stable. While for the length, there was no significant difference regarding its effect on ISQ values through-out the study period. Conclusions: DI inserted in the maxilla demonstrated better primary stability with no effect of recipient jaw on secondary stability and after functional loading, also DI with wider diameter had better stability throughout the study whereas DI length showed no significant effect on stability

scholarly journals Is gingival biotype a critical determinant of secondary stability of orthodontic mini-implants – A prospective clinical study using resonance frequency analysis

2020 ◽  
Vol 10 ◽  
pp. 245-252
Author(s):  
Sayali Prashant Pradhan ◽  
Supriya Nambiar ◽  
Shravan Shetty ◽  
Siddarth Shetty ◽  
Nidhin Philip Jose
Keyword(s):  
Resonance Frequency ◽  
Frequency Analysis ◽  
Prospective Clinical Study ◽  
Longitudinal Assessment ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Mini Implants ◽  
Significant Difference ◽  
Gingival Biotype ◽  
Secondary Stability

Objectives: The objectives of the study were to determine the association of gingival biotype and secondary stability of orthodontic mini-implants using resonance frequency analysis. Materials and Methods: Twenty patients, each receiving two mini-implants, were divided into two groups; thick and thin gingival biotype based on the thickness of gingiva before mini-implant placement. Implant stability was assessed at the time of placement; at the 1st, 2nd, 3rd, and 4th month by resonance frequency analysis. Peri-implant soft-tissue conditions were also examined at each month till 4 months interval using periodontal indices. Results: Thick and thin gingival biotype groups showed statistically different implant stability quotient (ISQ). Mini-implants showing signs of failure consistently displayed lesser ISQ. Statistically significant difference was observed in the scores of peri-implant indices of failure and no failure group of mini-implants. Conclusion: Mini-implants in thin gingival biotype are more susceptible to failure and peri-implantitis compared to thick gingival biotype. Longitudinal assessment of mini-implant stability may help predict failure so as to avoid long duration and cost of orthodontic treatment.

scholarly journals Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

2020 ◽  
Vol 10 (6) ◽  
pp. 1939 ◽  
Author(s):  
Moon Hwan Jung ◽  
Jeong Hun Lee ◽  
Puneet Wadhwa ◽  
Heng Bo Jiang ◽  
Hyon Seok Jang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Regeneration Capacity ◽  
Histomorphometric Analysis ◽  
Implant Stability ◽  
Micro Computed Tomography ◽  
Platelet Rich Fibrin ◽  
New Zealand White Rabbits ◽  
Bone To Implant Contact ◽  
The Mean

Tooth biomaterial may be useful in bone regeneration for restoring peri-implant defects in vivo. The aim of this study was to compare bone regeneration capacity in peri-implant defects augmented with autogenous tooth biomaterial combined with platelet-rich fibrin (PRF), tooth biomaterial alone, or PRF alone. Two monocortical defects were generated on each tibia of 10 New Zealand white rabbits (n = 10 per group) with a trephine bur, and the dental implant was installed into the defects. In experimental groups 1, 2, and 3, the peri-implant defects were filled with tooth biomaterial and platelet-rich fibrin (PRF), tooth biomaterial only, and PRF only, respectively and the control was left empty. Micro computed tomography (CT), implant stability, and histomorphometric analysis were conducted eight weeks after operation. The mean regenerated bone areas were 53.87 ± 7.60%, 51.56 ± 6.45%, and 18.45 ± 1.34% in experimental groups 1, 2, and 3, respectively, and 11.57 ± 1.12% in the control. Mean bone-to-implant contact values were 43.67 ± 2.50%, 41.07 ± 2.59%, and 21.45 ± 1.25% in experimental groups 1, 2, and 3, respectively, and 16.57 ± 2.83% in the control. Tooth biomaterial enriched with platelet-rich fibrin (PRF) and tooth biomaterial alone showed more enhanced regeneration than PRF alone in our study.

Influence of implant design, length, diameter, and anatomic region on implant stability: a randomized clinical trial

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
André Moreira ◽  
◽  
José Rosa ◽  
Filipe Freitas ◽  
Helena Francisco ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Primary Stability ◽  
Implant Design ◽  
Implant Stability ◽  
Anterior Maxilla ◽  
Implant Stability Quotient ◽  
Relevant Effect ◽  
Posterior Maxilla ◽  
Significant Difference ◽  
Secondary Stability

Objectives: To evaluate the influence of implant geometry and anatomical region on implant stability. Methods: A randomized controlled clinical trial was conducted on 45 patients, in whom a total of 79 implants were placed: 40 MIS C1 Implants and 39 MIS Seven Implants. The implant stability quotient was measured using resonance frequency analysis immediately after implant placement and 8 weeks later with an Osstell Mentor device. Results: 76 implants were analyzed. The implant stability quotient was statistically significantly higher for secondary stability than primary stability (68.7±8,6 vs. 65.2±10.3, respectively, p=0.023). Considering primary stability, no statistical differences were found between the implant lengths 8.0 mm, 10.0 mm, 11.0 mm, and 11.5 mm (67.9±7.6, 63.9±10, 57.2±11.1, and 66.4±11.3, respectively, p=0.312). The same was observed for secondary stability (68.4±9.4, 67.9±9.3, 74.7±1.5, and 69.2±7.9, respectively, p=0.504). Also, there were no statistically significant differences between the implant diameters 3.75 mm and 4.20 mm concerning primary stability (64.3±8.7 and 66.1±11.7 respectively, p=0.445) or secondary stability (68.8±8.2 and 68.7±9.1 respectively, p=0.930). Regarding implant design, a statistically significant difference was found only for secondary stability, favoring MIS Seven implants (p=0.048). The intraoral location was statistically significant for both primary and secondary stability, as these were higher on the anterior maxilla than the posterior maxilla and mandible (p<0.05). Conclusions: The diameter and length of the implants studied did not influence their stability. Implant design may influence secondary stability, whereas intraoral location has a relevant effect on primary and secondary stability.

scholarly journals Influence of implant design, length, diameter, and anatomic region on implant stability: a randomized clinical trial

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
André Moreira ◽  
◽  
José Rosa ◽  
Filipe Freitas ◽  
Helena Francisco ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Primary Stability ◽  
Implant Design ◽  
Implant Stability ◽  
Anterior Maxilla ◽  
Implant Stability Quotient ◽  
Relevant Effect ◽  
Posterior Maxilla ◽  
Significant Difference ◽  
Secondary Stability

Objectives: To evaluate the influence of implant geometry and anatomical region on implant stability. Methods: A randomized controlled clinical trial was conducted on 45 patients, in whom a total of 79 implants were placed: 40 MIS C1 Implants and 39 MIS Seven Implants. The implant stability quotient was measured using resonance frequency analysis immediately after implant placement and 8 weeks later with an Osstell Mentor device. Results: 76 implants were analyzed. The implant stability quotient was statistically significantly higher for secondary stability than primary stability (68.7±8,6 vs. 65.2±10.3, respectively, p=0.023). Considering primary stability, no statistical differences were found between the implant lengths 8.0 mm, 10.0 mm, 11.0 mm, and 11.5 mm (67.9±7.6, 63.9±10, 57.2±11.1, and 66.4±11.3, respectively, p=0.312). The same was observed for secondary stability (68.4±9.4, 67.9±9.3, 74.7±1.5, and 69.2±7.9, respectively, p=0.504). Also, there were no statistically significant differences between the implant diameters 3.75 mm and 4.20 mm concerning primary stability (64.3±8.7 and 66.1±11.7 respectively, p=0.445) or secondary stability (68.8±8.2 and 68.7±9.1 respectively, p=0.930). Regarding implant design, a statistically significant difference was found only for secondary stability, favoring MIS Seven implants (p=0.048). The intraoral location was statistically significant for both primary and secondary stability, as these were higher on the anterior maxilla than the posterior maxilla and mandible (p<0.05). Conclusions: The diameter and length of the implants studied did not influence their stability. Implant design may influence secondary stability, whereas intraoral location has a relevant effect on primary and secondary stability.

scholarly journals Correlation between Primary, Secondary Stability, Bone Density, Percentage of Vital Bone Formation and Implant Size

2021 ◽  
Vol 18 (13) ◽  
pp. 6994
Author(s):  
Vasilena Ivanova ◽  
Ivan Chenchev ◽  
Stefan Zlatev ◽  
Eitan Mijiritsky
Keyword(s):  
Bone Density ◽  
Bone Formation ◽  
Linear Correlation ◽  
Bone Biopsy ◽  
Primary Stability ◽  
Implant Stability ◽  
Socket Preservation ◽  
Implant Placement ◽  
Significant Difference ◽  
Secondary Stability

Background: This study aims to evaluate whether there is a correlation between implant stability, bone density, vital bone formation and implant diameter and length. Methods: Ninety patients were enrolled in this study. They underwent a socket preservation procedure with allograft or PRF and after 4 months, a total of 90 implants were placed. CBCT scans were assigned prior to implant placement in order to assess the bone density. During the surgical re-entry, a bone biopsy was harvested with a trephine drill. Immediately after implant insertion, the primary stability was measured. The secondary stability was measured 4 months after implant placement. Results: Primary stability showed a significant positive linear correlation with bone density (r = 0.471, p < 0.001) as well as with percentage of new bone formation (r = 0.567, p < 0.001). An average significant association of secondary stability with bone density (rs = 0.498, p < 0.001) and percentage of newly formed bone (r = 0.477, p < 0.001) was revealed. The mean values of primary stability in all three implant sizes, regarding the diameter of the implants, were similar (narrow 67.75; standard 66.78; wide 71.21) with no significant difference (p = 0.262). The same tendency was observed for secondary stability (narrow 73.83; standard 75.25; wide 74.93), with no significant difference (p = 0.277). Conclusions: The study revealed a high correlation between primary and secondary implant stability, and bone density, as well as with the percentage of vital bone formation. Implant length and diameter revealed no linear correlation with the implant stability.

scholarly journals Effectiveness of Silicon Platelet-Rich Fibrin and Autologous Bone on Bone Regeneration in Rabbit Calvarian Defects: A Radiological and Histological Study

2021 ◽  
Vol 11 (9) ◽  
pp. 4074
Author(s):  
Argimiro Hernández-Suarez ◽  
María Rizo-Gorrita ◽  
Dubraska Suárez-Vega ◽  
Gladys Velazco ◽  
Ivan Rodriguez Gelfenstein ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Oral Surgery ◽  
Histological Study ◽  
Study Groups ◽  
Control Group ◽  
Graft Material ◽  
Platelet Rich Fibrin ◽  
Computed Microtomography ◽  
Autologous Bone ◽  
Group 2

Repairing bone defects in oral surgery often requires the use of bone regeneration techniques. Silicon is an element that has been employed as regeneration material in several studies. In our study, silicon was combined with autologous bone and platelet-rich fibrin (PRF) membranes to analyse the behaviour of this element in bone regeneration. Four circumferential defects were created in the cranial vault of five New Zealand rabbits. The following elements were applied to the regeneration of the defects: (P): PRF; (S): silicon and (B): autologous bone, with the following distribution of study groups: Group 1 (PSB); Group 2 (PS); Group 3 (SB) and Group 4 (CONTROL): unregenerate group. The animals were sacrificed after 3 weeks. Computed microtomography studies (μ-CT) were carried out, as well as histomorphometric ones. The ANOVA statistical test was used with a Bonferroni post-hoc test to compare the results (p ≤ 0.05). Radiologically, groups PSB and SB were better as far as quantity and percentage of healthy bone observed, but not significantly compared to the control group. The PS group was significantly worse. The histological test revealed that the PSB group was the one to present the largest area, percentage and perimeter of mineralised bone. On evaluating the forming bone (osteoid), no difference was observed across the groups with the exception of the bone perimeter, where the SB group was significantly better. The bone height variable showed no significant differences. In conclusion we can state that the combination of PRF, autologous bone and silicon provides good results at 3 weeks whilst the PS group shows the worst results. This highlights the importance of autologous bone forming part of the graft material in order for the bone to mineralise.

Developing Stability of Posterior Mandibular Implants Placed With Osteotome Expansion Technique Compared With Conventional Drilling Techniques

2017 ◽  
Vol 43 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Yen-Ting Lin ◽  
Adrienne Hong ◽  
Ying-Chin Peng ◽  
Hsiang-Hsi Hong
Keyword(s):  
Bone Density ◽  
Surgical Techniques ◽  
Primary Stability ◽  
Conventional Technique ◽  
Implant Stability ◽  
Implant Stability Quotient ◽  
Expansion Technique ◽  
The Stability ◽  
Conventional Drilling ◽  
Secondary Stability

Clinical decisions regarding the stability and osseointegration of mandibular implants positioned using the bone expansion techniques are conflicting and limited. The objective was to evaluate the stability of implants placed using 2 surgical techniques, selected according to the initial width of the mandibular posterior edentulous ridge, with D3 bone density, during a 12-week period. Fifty-eight implants in 33 patients were evaluated. Thirty-two implants in 24 patients were positioned using the osteotome expansion technique, and 26 fixtures in 17 patients were installed using the conventional drilling technique. The implant stability quotient values were recorded at weeks 0, 1, 2, 3, 4, 6, 8, 10, and 12 postsurgery and evaluated using analysis of variance, independent, and paired t tests. Calibrated according to the stability reading of a 3.3-mm diameter implant, the osteotome expansion group was associated with a lower bone density than the conventional group (64.96 ± 6.25 vs 68.98 ± 5.06, P = .011). The osteotome expansion group achieved a comparable primary stability (ISQb-0, P = .124) and greater increases in secondary stability (ISQb-12, P = .07) than did the conventional technique. A D3 quality ridge with mild horizontal deficiency is expandable by using the osteotome expansion technique. Although the 2 groups presented similar implant stability quotient readings during the study period, the osteotome expansion technique showed significant improvement in secondary stability. The healing patterns for these techniques are therefore inconsistent.

Evaluation of the Effect of Platelet-Rich Fibrin on Wound Healing at Split-Thickness Skin Graft Donor Sites: A Randomized, Placebo-Controlled, Triple-Blind Study

2020 ◽  
pp. 153473461990043 ◽  
Author(s):  
Mojtaba Vaheb ◽  
Maryam Karrabi ◽  
Mahtab Khajeh ◽  
Alireza Asadi ◽  
Ehsan Shahrestanaki ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Outcome Evaluation ◽  
Control Group ◽  
Platelet Rich Fibrin ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Split-thickness skin grafting (STSG) is widely used to heal wounds resulting from trauma, burns, and chronic wounds. This study aimed to determine the true effect of platelet-rich fibrin (PRF) on patients with burn wounds requiring STSG during treatment of donor wounds. This randomized, triple-blind clinical trial was conducted on patients who referred to the burn ward of Vasei Hospital of Sabzevar, Iran, from May 2017 to May 2018. The donor site was randomly divided into 2 groups: PRF and control (Vaseline petrolatum gauze) using Vaseline gauze. In the intervention group, the PRF gel was applied to the wound and covered with Vaseline gauze and wet dressing. Conversely, only Vaseline gauze and wet dressing were applied to the control group. Outcome evaluation was conducted using paired t test and Wilcoxon signed rank-sum test, as appropriate, on days 8 and 15. The mean age of the patients was 33.10 ± 2.60 years, and 51.50% were male. The mean wound healing time in the PRF and control groups was 11.80 ± 3.51 and 16.30 ± 4.32 days, respectively ( P < .001). The PRF group showed significantly higher wound healing rates than the control group at 8 and 15 days dressing ( P < .001 and P < .001, respectively). Moreover, the mean wound healing for all wound healing indices diagnosed by 2 specialists in PRF was higher than control group on days 8 and 15 ( P < .001). We found a statistically significant difference on days 8 and 15 regarding the mean pain levels between the 2 groups ( P < .001). The findings showed that PRF can significantly increase the time and rate of donor wound healing compared with conventional treatment and also reduce the severity of pain.

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