scholarly journals Genetic aspects of obesity and metabolic syndrome in people occupationally exposed to arsenic and certain heavy metals

2020 ◽  
Vol 22 (1-2) ◽  
pp. 29-32
Author(s):  
Tomasz Matys ◽  
Anna Szymańska-Chabowska ◽  
Rafał Poręba ◽  
Grzegorz Mazur ◽  
Paweł Gać
2021 ◽  
Vol 273 ◽  
pp. 116480 ◽  
Author(s):  
Ping Xu ◽  
Aiping Liu ◽  
Fengna Li ◽  
Alexey A. Tinkov ◽  
Longjian Liu ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2666 ◽  
Author(s):  
Wei-Lun Wen ◽  
Chih-Wen Wang ◽  
Da-Wei Wu ◽  
Szu-Chia Chen ◽  
Chih-Hsing Hung ◽  
...  

Previous studies have revealed associations between heavy metals and extensive health problems. However, the association between heavy metals and metabolic problems remains poorly defined. This study aims to investigate relationships between heavy metals and metabolic syndrome (MetS), lipid accumulation product (LAP), visceral adiposity index (VAI), and anthropometric indices, including body roundness index (BRI), conicity index (CI), body adiposity index (BAI), and abdominal volume index (AVI). We conducted a health survey of people living in southern Taiwan. Six heavy metals were measured: lead (Pb) in blood and nickel (Ni), chromium (Cr), manganese (Mn), arsenic (As), and copper (Cu) in urine. A total of 2444 participants (976 men and 1468 women) were enrolled. MetS was defined according to the Adult Treatment Panel III for Asians. Multivariable analysis showed that participants with high urine Ni (log per 1 μg/L; odds ratio (OR): 1.193; 95% confidence interval (CI): 1.019 to 1.397; p = 0.028) and high urine Cu (log per 1 μg/dL; OR: 3.317; 95% CI: 2.254 to 4.883; p < 0.001) concentrations were significantly associated with MetS. There was a significant trend of a stepwise increase in blood Pb and urine Ni, As, and Cu according to the number of MetS components (from 0 to 5, a linear p ≤ 0.002 for trend). For the determinants of indices, urine Cu was positively correlated with LAP, BRI, CI, and VAI; blood Pb was positively correlated with BRI, BAI, and AVI; urine Ni was positively correlated with LAP. High urine Cu and urine Ni levels were significantly associated with MetS, and there was a significant trend for stepwise increases in blood Pb and urine Ni, As, and Cu, accompanied by an increasing number of MetS components. Furthermore, several indices were positively correlated with urine Cu, urine Ni, and blood Pb.


2015 ◽  
Vol 12 (4) ◽  
pp. 3944-3961 ◽  
Author(s):  
Iwona Rotter ◽  
Danuta Kosik-Bogacka ◽  
Barbara Dołęgowska ◽  
Krzysztof Safranow ◽  
Anna Lubkowska ◽  
...  

1984 ◽  
Vol 35 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Guy Huel ◽  
Richard B. Everson ◽  
Isabelle Menger

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S147-S148
Author(s):  
I S Bocsan ◽  
M I Brumboiu ◽  
M Vlad ◽  
C Roman ◽  
M Ponta ◽  
...  

2007 ◽  
Vol 23 (3) ◽  
pp. 161-165 ◽  
Author(s):  
O.E. Orisakwe ◽  
E. Nwachukwu ◽  
H.B. Osadolor ◽  
O.J. Afonne ◽  
C.E. Okocha

Lead, cadmium, nickel and other industrial metals used as part of paint varnishes have been reported to have adverse health implications. An evaluation study on some toxicological effects of occupational exposure to paint, among 25 occupationally exposed artisans and 25 students (control) of Ichi Technical College, Ichi Ekwusigo Local Government Area, Anambra State, Nigeria was carried out. Heavy metals were analysed by atomic absorption spectrophotometry and standard assay procedures were employed for biochemical parameters. The biochemical indices used include serum electrolytes urea, creatinine, alanine (ALT) and aspartate aminotransferases (AST), alkaline phosphatase (ALP), conjugated and total bilirubin. Others include blood lead, serum cadmium and nickel. Our results showed that occupational exposure of humans to paints increased the blood lead (39 ± 4 μg/dL), serum cadmium (13 ± 1 μg/dL) and nickel (63 ± 1 μg/dL), when compared with non-paint factory workers (PFW) lead (17 ± 4 μg/dL), serum cadmium (9 ± μg/dL) and nickel (25 ± 44 μg/dL), significantly at P < 0.05 lower values were observed for serum sodium (138.96 ± 0.58mmol/L), bicarbonate (26.88 ± 0.39 mmol/L), urea (3.15 ± 0.13 mmol/L) and creatinine (80.48 ± 1.04 μmol/L) for paints factory workers when compared with non-paint factory workers, sodium (139.84 ±0.62mmol/L), bicarbonate (26.20 ±0.22mmol/L), urea (3.44 ± 0.11 mmol/L) and creatinine (80.40 ± 1.55 μmol/L); at P > 0.05. The activities of AST (10.36 ± 0.58 μ/L), ALT(8.76 ± 0.47 μ/L) and ALP (47.12 ± 3.33 μ/L) in PFW were slightly elevated compared with non-PFW. Our result indicates that occupational exposure of humans to heavy metals in paints may have long term deleterious effects on liver and renal functions. In conclusion, it should be noted that occupational exposure to cadmium or lead among PFW, may compromise the liver and renal functions in man. Toxicology and Industrial Health 2007; 23: 161—165.


2017 ◽  
Vol 10 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Aziza Abdel Azim Saad ◽  
Mohamed Abdel Mohsen ◽  
Said M. Kandil ◽  
Ezzat M. Hassan ◽  
Magda Abdel Ghani Megahed ◽  
...  

2019 ◽  
Vol 7 (6) ◽  
pp. 184
Author(s):  
Okonkwo Francis Obiora ◽  
Benjamin Danladi ◽  
Bege Jonathan ◽  
Uzonu Ikenna Ugonna ◽  
John Barnabas Nvau ◽  
...  

Author(s):  
Yun Shim ◽  
Jung Ock ◽  
Yoon-Ji Kim ◽  
Youngki Kim ◽  
Se Kim ◽  
...  

The incidence of metabolic syndrome (MetS), which causes heart disease and stroke, has increased significantly worldwide. Although many studies have revealed the relationship between heavy metals (cadmium, mercury, and lead), the sum of metabolites of di(2-ethylhexyl) phthalate (DEHP), and MetS, the results remain inconsistent. No study has reported the association between various volatile organic compounds (VOCs) and phthalate metabolites with MetS. This cross-sectional study of a representative sample of adult South Koreans aimed to evaluate the relationship between heavy metals, VOC metabolites, phthalate metabolites, bisphenol A and MetS after adjusting for demographic variables. Data from the Korean National Environmental Health Survey II (2012–2014) (n = 5251) were used in the analysis. Multiple logistic regression analysis was performed for MetS with log-transformed hazardous material quartiles after covariate adjustment. Urine muconic acid (MuA) and mono- (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) levels were significantly associated with MetS after adjusting for confounders (odds ratio: 1.34 and 1.39, respectively). Urine MuA and MEHHP levels were significantly associated with MetS. Because of the rarity of this study, which investigated the relationship between each VOC and phthalate metabolite with MetS and the strict definition of all indirect measures of MetS components, further research is needed.


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