scholarly journals Hypolipidemic action of Rutin on Triton WR-1339 induced hyperlipidemia in rats

2021 ◽  
Author(s):  
Livingston NR ◽  
Aathira Ravindran Nair ◽  
Swarnabala Senthilpandian ◽  
Vijay Ravi
Keyword(s):  
Hypolipidemic Action ◽  
Triton Wr 1339

The hypolipidemic action of a diet supplemented withp,p’-methoxyl-diphenyl diselenide is not directly related to its antioxidant property

2016 ◽  
Vol 94 (6) ◽  
pp. 662-668 ◽  
Author(s):  
Carla Elena Sartori Oliveira ◽  
Simone Pinton ◽  
Juliana Trevisan da Rocha ◽  
Bibiana Mozzaquatro Gai ◽  
Cristina Wayne Nogueira
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Antioxidant Property ◽  
Atherogenic Index ◽  
Hypolipidemic Effect ◽  
Diphenyl Diselenide ◽  
Hypolipidemic Action ◽  
Triton Wr 1339 ◽  
Rule Out

The present study investigated whether a p,p’-methoxyl-diphenyl diselenide (MeOPhSe)2-supplemented diet causes toxicity in rats. A second aim of this study was to determine whether a 10 ppm (MeOPhSe)2-supplemented diet has hypolipidemic effect on Triton WR-1339-induced hyperlipidemia in rats. To rule out the antioxidant property of (MeOPhSe)2in its hypolipidemic action, parameters of oxidative stress were carried out. Wistar rats were fed with 3, 10, or 30 ppm of (MeOPhSe)2-supplemented diet for 30 days. None of (MeOPhSe)2-supplemented diets caused alteration in general parameters of toxicity and lipid profile of rats. The hypolipidemic effect of 10 ppm of (MeOPhSe)2-supplemented diet on rats treated with Triton WR-1339 (400 mg/kg, intraperitoneal) was investigated. The (MeOPhSe)2-supplemented diet partially protected against the levels of total cholesterol (TC) and non-HDL-C and reduced the atherogenic index (AI) increased by Triton WR-1339 in rats. A positive correlation between TC and triglyceride levels (r = 0.679) and non-HDL-C levels (r = 0.929) and AI (r = 0.889) was demonstrated. Triton WR-1339 altered parameters of oxidative stress in livers of rats but (MeOPhSe)2-supplemented diet did not protect against these alterations. The results demonstrated that the hypolipidemic action of (MeOPhSe)2-supplemented diet is not directly related to its antioxidant property and devoid of systemic toxicity in rats at the parameters analyzed.

scholarly journals Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice

2014 ◽  
Vol 1 ◽  
pp. 200-208 ◽  
Author(s):  
Micheli Stéfani Zarzecki ◽  
Stífani M. Araujo ◽  
Vandreza C. Bortolotto ◽  
Mariane Trindade de Paula ◽  
Cristiano Ricardo Jesse ◽  
...  
Keyword(s):  
Hypolipidemic Action ◽  
Triton Wr 1339

L’extrait phénolique de l’enveloppe charnue d’amande (Prunus amygdalus L.) restaure le métabolisme lipidique chez la souris hyperlipidémique et prévient l’oxydation des lipoprotéines plasmatiques

2019 ◽  
Author(s):  
M. Harnafi ◽  
I. Touiss ◽  
S. Khatib ◽  
O. Bekkouch ◽  
M. Rouis ◽  
...  
Keyword(s):  
Prunus Amygdalus ◽  
Maladies Cardiovasculaires ◽  
Triton Wr 1339 ◽  
Profil Lipidique

Ce travail a été conçu pour étudier l’effet d’un extrait riche en polyphénols de l’enveloppe charnue de l’amande douce sur le profil lipidique plasmatique chez la souris rendue hyperlipidémique par le Triton WR-1339 ainsi que sur la prévention de l’oxydation des lipoprotéines plasmatiques en comparaison avec le fénofibrate et l’hydroxyanisole butylé. On note que l’extrait phénolique réduit significativement le cholestérol total plasmatique de 58 % (p < 0,001) et les triglycérides de 62 % (p < 0,001). Par ailleurs, cet extrait réduit significativement le taux élevé du cholestérol-LDL de 61 % (p < 0,05) et augmente le cholestérol-HDL de 71 % (p < 0,05). Un tel extrait abaisse aussi significativement la valeur de l’indice d’athérogénicité de −72 % (p < 0,01) et celle du rapport LDL/ HDL de 55 % (p < 0,05). En outre, cet extrait possède un effet antiradical 2,2-diphényl-1-picrylhydrazyl dosedépendant avec une CI50 = 18,8 ± 0,55 μg/ml et inhibe significativement l’oxydation du plasma riche en lipoprotéines (CI50 = 13,8 ± 0,57 μg/ml). Nos résultats montrent que l’extrait est riche en polyphénols à caractère polaire (polyphénols totaux : 342,63 ± 3,44 mg/g, tannins : 144,67 ± 6,83 mg/g, flavonoïdes : 20,66 ± 0,92 mg/g) qui pourraient améliorer le métabolisme lipidique et prévenir l’oxydation des lipoprotéines et ainsi avoir un effet bénéfique dans la prévention de l’athérosclérose et des maladies cardiovasculaires qui en résultent.

Regulation of lipoprotein lipase activity in cardiac myocytes from control and diabetic rat hearts by plasma lipids

1992 ◽  
Vol 70 (9) ◽  
pp. 1271-1279 ◽  
Author(s):  
Brian Rodrigues ◽  
Janice E. A. Braun ◽  
Michael Spooner ◽  
David L. Severson
Keyword(s):  
Lipoprotein Lipase ◽  
Cardiac Myocytes ◽  
Lipase Activity ◽  
Plasma Lipids ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Lipoprotein Lipase Activity ◽  
Triton Wr 1339 ◽  
Plasma Triacylglycerol

The objective of this investigation was to test the hypothesis that the diabetes-induced reduction in lipoprotein lipase activity in cardiac myocytes may be due to hypertriglyceridemia. Administration of 4-aminopyrazolopyrimidine (50 mg/kg) to control rats for 24 h reduced plasma triacylglycerol levels and increased the heparin-induced release of lipoprotein lipase into the incubation medium of cardiac myocytes. The acute (3–5 days) induction of diabetes by streptozotocin (100 mg/kg) produced hypertriglyceridemia and reduced heparin-releasable lipoprotein lipase activity in cardiac myocytes. Treatment of diabetic rats with 4-aminopyrazolopyrimidine resulted in a fall in plasma triacylglycerol content and increased heparin-releasable lipoprotein lipase activity. Administration of Triton WR-1339 also resulted in hypertriglyceridemia, but the heparin-induced release of lipoprotein lipase from control cardiac myocytes was not reduced in the absence of lipolysis of triacylglycerol-rich lipoproteins. Treatment with Triton WR-1339 did, however, increase the heparin-induced release of lipoprotein lipase from diabetic cardiac myocytes. Preparation of cardiac myocytes with 0.9 mM oleic acid resulted in a decrease in both total cellular and heparin-releasable lipoprotein lipase activities. These results suggest that the diabetes-induced reduction in heart lipoprotein lipase activity may, at least in part, be due to an inhibitory effect of free fatty acids, derived either from lipoprotein degradation or from adipose tissue lipolysis, on lipoprotein lipase activity in (and (or) release from) cardiac myocytes.Key words: diabetes, plasma triacylglycerols, cardiac myocytes, lipoprotein lipase.

The Fate of Chylomicrons in Rats Treated with Triton WR-1339

1965 ◽  
Vol 16 (1) ◽  
pp. 135-140
Author(s):  
W. TAFT MOORE ◽  
HERBERT C. TIDWELL ◽  
JAMES C. MCPHERSON
Keyword(s):  
Triton Wr 1339

scholarly journals HYPOLIPIDEMIC THERAPY IN PATIENTS AFTER HEART TRANSPLANTATION: STATINS

2016 ◽  
Vol 18 (2) ◽  
pp. 171-176
Author(s):  
A. О. Shevchenko
Keyword(s):  
Acute Rejection ◽  
Heart Transplantation ◽  
Statin Therapy ◽  
Standard Therapy ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Allograft Vasculopathy ◽  
Hypolipidemic Action ◽  
Long Term Prognosis

Statins should be used as a part of standard therapy in patients after heart transplantation. The effectiveness of statins is associated not only with their hypolipidemic action, but also with their immunomodulatory and antineoplastic properties. Statin therapy initiated early after heart transplantation improves the shortand long-term prognosis and outcomes, leading to a reduction in the incidence of cardiac allograft vasculopathy, acute rejection, and cancer. 

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