scholarly journals Using meldonium to improve adaptation of patients with hypertension and pre-diabetes to influence of heat

2015 ◽  
Vol 12 (4) ◽  
pp. 46-50
Author(s):  
M D Smirnova ◽  
O N Svirida ◽  
F T Ageev ◽  
T V Fofanova ◽  
M V Vitsenya ◽  
...  

Aim of the study was to evaluate the effect of meldonium the state of cardiovascular system and the quality of life of patients with arterial hypertension (AH) combined with pre-diabetes under the summer heat.Materials and methods. 45 hypertensive patients 51-76 years old with pre-diabetes. randomized to active management (M), which in addition to basic therapy received during the 3 summer months meldonium 1000 mg/day, and a control (C). Body mass index, office blood pressure, blood chemistry, HbA1c, pulse wave velocity (PWV), tissue glycation, visual analogue scale (VAS) were performed.Results. The trend to lower heart rate during the heat of the group M. In September, a trend increase in PWV (ΔPWV=1.7 m/s; p =0.056) in group C. Lipid and carbohydrate metabolism do not change. In both groups the trend to an increase in the level of sodium in the heat, in group M it remained until September. Increase sodium during heat greater in group M (Δ2.0 mmol/l vs 1,0 mmol/1); p =0.05. In group C, tendency to decrease VAS scores from 70 to 55 ( p =0.07) in group M trend to increase from 60 to 70 ( p =0.07), the differences between the groups were significant ( p =0.01). In group M trend continued in September.Conclusion. Meldonium can be used as an adaptogen in the period of summer heat in patients with hypertension in combination with pre-diabetes.

2020 ◽  
Vol 08 (11) ◽  
pp. 5189-5192
Author(s):  
Baghel Singh Manoj ◽  
Mishra Nripendra

In today's era Amvata has emerged as a challenging entity as it comes under the umbrella of Yapya or Kric-chrasadhya (not easy to treat) category which has no permanent cure but quality of life can be improved to a great extent through Ayurveda management as compared to contemporary modern treatment which has yet not found significant remedy along with a lots of side effects Objective-So here a case study has been presented which was conducted in our hospital in which patient was treated with Avasthanusar (Stagewise) multifaceted approach in Ayurvedic management which may be effective in treating the disease. Materials and Methods- patient aged 27 with typical signs and symptoms of Amvata as per classical and modern texts and his VAS Scores (Visual Analogue Scale), RA factor, CRP, Uric acid levels confirmed the diagno-sis. Outcomes – patient showed significant improvement in both objective and subjective parameters. Con-clusion - Avasthanusar (Stagewise) multifaceted approach in Ayurvedic management of Amavata may be effective in treating the disease.


Author(s):  
Javier Benítez ◽  
Nieves Perejón ◽  
Marcelino Arriaza ◽  
Pilar Bellanco

Loneliness has always been associated and reported as a risk factor of malnutrition in the elderly. People over 80 who live alone have deserved this study to detect their situation and potential for action to improve their quality of life. Objectives: To determinate the nutritional status of people over 80 living alone in the area of “La Laguna”, Cádiz. Material and method: In PIAMLA`80 program analyse those parameters and their possible correlations in a group of 342 elderly living alone over 80 years old. Different parameters were measured: Integral Geriatric Evaluation, Barthel, Lawton-Brody, Lobo, Gijon, specific analytical blood chemistry and MNA. Results: In a population of 984 people, were selected 342 initially, but finally the group decreases to 247 people. The mean Barthel was 80.42 points, 5.76 Lawton and Gijon from 11.3 Lobo 26.48. The MNA for the whole population was 24.25/30 detecting only a risk age group in women of 85-95. Correlation between nutrition and the biochemical test values showed positive for haemoglobin (0.19), total protein (0.26), Fe (0.32) and albumin (0.46). Conclusions: In our research we have not detected malnutrition in any age group or gender. The use of nutrition test MNA and its MINI version must be generalized as an accurate, clear, quick and easy tool to use.


2007 ◽  
Vol 8 (3) ◽  
pp. 10 ◽  
Author(s):  
Margaret A Cavalcante ◽  
M Teresa NB Manzoli ◽  
Luna F Braulio ◽  
Yona A Francisco ◽  
Luigi Brollo ◽  
...  

2010 ◽  
Vol 32 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Baris Afsar ◽  
Rengin Elsurer ◽  
Siren Sezer ◽  
Fatma Nurhan Ozdemir

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Lourdes Carhuapoma ◽  
Radhika Avadhani ◽  
Noeleen Ostapkovich ◽  
Karen Lane ◽  
Nichol McBee ◽  
...  

Introduction: Recovery in intracerebral hemorrhage (ICH) is prolonged and unpredictable, resulting in challenges in estimating health-related quality of life (HRQoL). We describe HRQoL and patient disposition for ICH survivors with similar clinical characteristics to ICH patients who had withdrawal of life-sustaining treatment (WoLST). Methods: Using MISTIE III trial data (N = 499), we performed a matched cohort analysis using a published modified severity index (mSI) to compare ICH survivors (N = 379) with WoLST patients (N = 61). We used multivariable logistic regression adjusting for age, Glasgow Coma Score, deep ICH location, stability ICH and intraventricular hemorrhage volume and ≥ 3 comorbidities to create the mSI. After matching survivors with equal mSI to WoLST patients, we compared EuroQoL (EQ) visual analog scale (VAS) scores (US norm 69-76; range 0-100) by mSI quartile and patient disposition. Results: We matched 224 survivors to WoLST patients by mSI (range 0-6.5), with data at all timepoints. Given the large mSI range, EQ VAS scores and patient disposition were evaluated by mSI quartile groups. The median (interquartile range [IQR]) EQ VAS score increase for all mSI groups from day 30 (D30) to 180 (D180) was 20 (0-35.5, p < 0.0001), and 23.5 (5-40, p < 0.0001) for D30 to 365 (D365). The highest percentage of survivors for all mSI groups were home by D365 (G1 55%, G2 88%, G3 84.5%, G4 90%). Median (IQR) EQ VAS scores by mSI quartile, patient disposition and timepoint are reported below. Conclusion: ICH survivors, matching WoLST individuals, in all mSI groups demonstrated improvement in HRQoL over time, and the majority were home by D365. This study challenges current practice of identifying poor outcomes in concert with decision making employing WoLST in ICH. If goals of care are to include return to home and HRQoL, these results strongly suggest that prognostication can be improved. Prospective studies of ICH prognostication and decision making are needed.


2015 ◽  
Vol 6 (10) ◽  
pp. 720-723
Author(s):  
Nandikol P Sunanda ◽  
Master S A ◽  
K Niyati Raj ◽  
G Sushen ◽  
M S Laxshmi

Author(s):  
Tiara Dewi Salindri Pratama ◽  
Nanang Munif Yasin ◽  
Susi Ari Kristina

Medication therapy management (MTM), is a service model aimed at helping general health problems by preventing morbidity and mortality. Hypertension is a non-communicable disease which is a serious health problem which requires long-term therapy.  This study aims to see the effect of MTM on clinical Outcomes and quality of life of patients in hypertensive patients. This type of research is a quasi experimental one group with a pretest-posttest design. Analysis using paired sample t-test and Wilcoxon test with a significance used P <0,05. Respondents were 70 people, 67,1% were women. The characteristics of the majority age are 55-64 years with a percentage of 51,4%, the majority of education level is high school with 42,8%, non-civil servant jobs with a percentage of 45,7%, the length of diagnosis is dominated by 1-10 years (77,1%) and comorbidities diabetes mellitus occurred the most (10,0%). The results showed that the quality of life increased from before getting MTM 54,4 ± 8,9 and after MTM intervention 60,4 ± 6,6 (P value <0,001). Clinical outcome from systolic 159,2 ± 8,9 mmHg and diastolic 103,8 ± 8,0 mmHg before MTM to 144,1 ± 14,4 mmHg for systolic and 89,7 ± 8,8 mmHg for diastolic with p value <0,001 (p <0,05) for systolic blood pressure and p value: 0,016 (p <0,05) after receiving MTM intervention. Medication Therapy Management (MTM) has a significant influence on improving the quality of life and clinical Outcomes of hypertensive patients. The higher the quality of life of patients, blood pressure becomes more controlled.


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