scholarly journals Nebivolol for treatment patients with arterial hypertension

2014 ◽  
Vol 11 (3) ◽  
pp. 83-87
Author(s):  
O M Mikheeva ◽  
I A Komisarenko
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Oxidative Degradation ◽  
Blocking Agent ◽  
Blocking Effect ◽  
Beta Adrenergic ◽  
Adrenergic Blocking

Beta-adrenergic blocking agent is included in the group of primary agentsfor treatment of patients with AH. In the pathogenesis of AH,one of the main causes leading to raisingthe blood pressure isendothelial dysfunction.Correction ofendothelial dysfunctionis AH treatment strategic aim.Nebivololis a cardioselectivethird-generationvasodilatingβ-adrenergic blocking agent, which is in addition toβ-adrenergic blocking effect, can alsoincrease endogenousproduction of NOin the endothelial cellsdue to the decreasing of oxidative degradation. As a result,nebivololprovides positivehemodynamic effects on patients with AH, decreasingperipheral resistanceandblood pressure.

Pindolol: A Potent Beta-Adrenergic Blocking Agent in the Treatment of Hypertension

1978 ◽  
Vol 6 (6) ◽  
pp. 435-440 ◽  
Author(s):  
Nibha Jaroonvesma ◽  
Kawi Charoenlarp
Keyword(s):  
Blood Pressure ◽  
Combined Therapy ◽  
Blocking Agent ◽  
Efficacy And Safety ◽  
Beta Adrenergic ◽  
Hypertensive Patients ◽  
Significant Lowering ◽  
Treatment Of Hypertension ◽  
Adrenergic Blocking

Two groups of twenty-five hypertensive patients each were treated with a beta-adrenergic blocking agent (pindolol), either alone or in combination with classical antihypertensives. In the group under monotherapy a significant lowering of the blood pressure was observed. The effect was, however, not so consistent as in the group under combined therapy. The trial shows the efficacy and safety of pindolol in the treatment of hypertension mainly if applied in combination with a diuretic.

Massive Clonidine Ingestion with Hypertension in a 9-Month-Old Infant

PEDIATRICS ◽  
1983 ◽  
Vol 72 (4) ◽  
pp. 500-502
Author(s):  
Pablo Yagupsky ◽  
Rafael Gorodischer
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Drugs ◽  
Complete Recovery ◽  
Blocking Agent ◽  
Assisted Ventilation ◽  
Antagonistic Effect ◽  
Arterial Blood ◽  
Clonidine Poisoning ◽  
Adrenergic Blockers ◽  
Adrenergic Blocking

The antihypertensive drug clonidine has a double and antagonistic effect on arterial blood pressure. As a result of activation of peripheral α-adrenergic receptors, it causes a transient increase in blood pressure; by a central action it decreases sympathetic tone which results in sustained bradycardia and hypotension. Both central and peripheral effects are experimentally blocked by tolazoline, an α-adrenergic blocking agent. The toxic symptoms seen in clonidine poisoning are usually produced by the central effect. A case of severe clonidine poisoning in a 9-month-old infant is reported. The clinical picture included coma, miosis, apneic spells, bradycardia, and hypertension. Rapid and complete recovery was obtained with supportive treatment that included assisted ventilation. No adrenergic blockers or antihypertensive drugs were given. Use of tolazoline in cases of clonidine overdose in children remains controversial. Supportive measures alone may be adequate for even the most severe cases.

Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats—I

1976 ◽  
Vol 25 (16) ◽  
pp. 1837-1842 ◽  
Author(s):  
Seiji Morita ◽  
Yasuo Irie ◽  
Yuichi Saitoh ◽  
Hideaki Kohri
Keyword(s):  
Blocking Agent ◽  
Metabolic Responses ◽  
Beta Adrenergic ◽  
Adrenergic Blocking

scholarly journals 14C-labelling of a new .BETA.-adrenergic blocking agent (S-596)

RADIOISOTOPES ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 101-103 ◽  
Author(s):  
Akira YOSHITAKE ◽  
Hideyuki GOMI ◽  
Iwao NAKATSUKA
Keyword(s):  
Blocking Agent ◽  
Beta Adrenergic ◽  
14C Labelling ◽  
Adrenergic Blocking
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