scholarly journals Systemic inflammation as a risk factor for cardiovascular disease: review of the literature

2018 ◽  
Vol 9 (1) ◽  
pp. 40-46
Author(s):  
I. M Marusenko ◽  
I. I Polskaya
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Systemic Inflammation ◽  
Genetically Engineered ◽  
Review Of The Literature ◽  
Eular Recommendations ◽  
Cardiovascular Morbidity And Mortality ◽  
Key Factor ◽  
Inflammatory Drugs

The review shows the problem of systemic inflammation as a key factor influencing the cardiovascular morbidity and mortality in patients with autoimmune rheumatic diseases. Represented literature data on the role of inflammation in the pathophysiology of cardiovascular disease in rheumatoid arthritis, its impact on the accelerated development of atherosclerosis. A separate section is devoted to the problem of lipid paradox. Review shows data on the influence of the traditional basic anti-inflammatory drugs and genetically engineered biological agents on the risk of cardiovascular disease in rheumatoid arthritis. Also, EULAR recommendations for assessing the risk of cardiovascular disease in rheumatoid arthritis.

scholarly journals Hydroxychloroquine: Looking into the Future

2017 ◽  
Vol 24 (4) ◽  
pp. 369-375 ◽  
Author(s):  
Saibal Chakravorty ◽  
Indranil Purkait ◽  
Anil Pareek ◽  
Avinash Talware
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Systemic Inflammation ◽  
Cardiovascular Effects ◽  
Lipid Lowering ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

AbstractHydroxychloroquine, an antimalarial agent has also been found to possess antidiabetic action. Onset of type-2 diabetes (T2DM) and cardiovascular disease is now considered to be the outcome of systemic inflammation. Many clinical trials are targeting systemic inflammation to reduce cardiovascular risk. Anti-inflammatory drugs with cardiovascular effects may be valuable therapeutic intervention to reduce massive cardiovascular risk in T2DM. In this review, antidiabetic action and potential cardioprotective role of hydroxychloroquine has been discussed. By virtue of its antidiabetic, lipid lowering, anti-platelet, anticoagulant and anti-inflammatory properties, hydroxychloroquine can be a key therapeutic alternative to manage patients with T2DM.

scholarly journals Safety and efficiency of therapy by gene-engineering-biological preparations of rheumatoid arthritis

2018 ◽  
Vol 9 (3) ◽  
pp. 44-49
Author(s):  
E. A. Strel’tsov
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Randomized Trials ◽  
Web Of Science ◽  
Genetically Engineered ◽  
Systematic Literature Search ◽  
Efficacy And Safety ◽  
Review Of The Literature ◽  
Gene Engineering

In this review of the literature, questions of the efficacy and safety of therapy with genetically engineered biological preparations for rheumatoid arthritis are discussed. The results of randomized trials of recent years are described in detail. Systematic literature search was conducted on the databases Scopus, Web of Science, MedLine, elibrary and others.

scholarly journals The Role of Simvastatin in the Therapeutic Approach of Rheumatoid Arthritis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Lucia Cojocaru ◽  
Andrei Constantin Rusali ◽  
Cristina Şuţa ◽  
Anca Mihaela Rădulescu ◽  
Maria Şuţa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Active Rheumatoid Arthritis ◽  
Therapeutic Potential ◽  
Efficacy And Safety ◽  
Good Safety Profile ◽  
Study Support ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The pleiotropic effects of statins, especially the anti-inflammatory and immunomodulatory ones, indicate that their therapeutic potential might extend beyond cholesterol lowering and cardiovascular disease to other inflammatory disorders such as rheumatoid arthritis. Therefore, we undertook a prospective cohort study to evaluate the efficacy and safety of simvastatin used for inflammation control in patients with rheumatoid arthritis. One hundred patients with active rheumatoid arthritis divided into two equal groups (the study one who received 20 mg/day of simvastatin in addition to prior DMARDs and the control one) were followed up over six months during three study visits. The results of the study support the fact that simvastatin at a dose of 20 mg/day has a low anti-inflammatory effect in patients with rheumatoid arthritis with a good safety profile.

scholarly journals Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: The role of obesity and smoking

2009 ◽  
Vol 204 (1) ◽  
pp. 178-183 ◽  
Author(s):  
Vasileios F. Panoulas ◽  
Antonios Stavropoulos-Kalinoglou ◽  
Giorgos S. Metsios ◽  
Jacqueline P. Smith ◽  
Haralampos J. Milionis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Gene Polymorphism ◽  
Interleukin 6

scholarly journals Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis

2014 ◽  
Vol 74 (6) ◽  
pp. 1118-1123 ◽  
Author(s):  
Inmaculada del Rincón ◽  
Joseph F Polak ◽  
Daniel H O'Leary ◽  
Daniel F Battafarano ◽  
John M Erikson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Systemic Inflammation ◽  
Intima Media Thickness ◽  
Rapid Progression ◽  
Progression Rate ◽  
Atherosclerosis Progression ◽  
Baseline Factors

ObjectiveTo estimate atherosclerosis progression and identify influencing factors in rheumatoid arthritis (RA).MethodsWe used carotid ultrasound to measure intima-media thickness (IMT) in RA patients, and ascertained cardiovascular (CV) risk factors, inflammation markers and medications. A second ultrasound was performed approximately 3 years later. We calculated the progression rate by subtracting the baseline from the follow-up IMT, divided by the time between the two scans. We used logistic regression to identify baseline factors predictive of rapid progression. We tested for interactions of erythrocyte sedimentation rate (ESR) with CV risk factors and medication use.ResultsResults were available for 487 RA patients. The mean (SD) common carotid IMT at baseline was 0.571 mm (0.151). After a mean of 2.8 years, the IMT increased by 0.050 mm (0.055), p≤0.001, a progression rate of 0.018 mm/year (95% CI 0.016 to 0.020). Baseline factors associated with rapid progression included the number of CV risk factors (OR 1.27 per risk factor, 95% CI 1.01 to 1.61), and the ESR (OR 1.12 per 10 mm/h, 95% CI 1.02 to 1.23). The ESR×CV risk factor and ESR×medication product terms were significant, suggesting these variables modify the association between the ESR and IMT progression.ConclusionsSystemic inflammation and CV risk factors were associated with rapid IMT progression. CV risk factors may modify the role of systemic inflammation in determining IMT progression over time. Methotrexate and antitumour necrosis factor agents may influence IMT progression by reducing the effect of the systemic inflammation on the IMT.

scholarly journals THE ROLE OF ANGIOPOIETIN-LIKE PROTEINS IN THE DEVELOPMENT OF RENAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND METABOLIC CHANGES

2020 ◽  
Vol 76 (4) ◽  
pp. 37-41
Author(s):  
V.A. Aleksandrov ◽  
◽  
L.N. Shilova ◽  
A.V. Aleksandrov ◽  
◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Renal Dysfunction ◽  
Estimated Glomerular Filtration Rate ◽  
Average Duration ◽  
Metabolic Changes ◽  
Average Strength ◽  
Two Factors ◽  
Key Factor ◽  
The Relationship

The article is devoted to the assessment of the relationship between the serum concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the development of renal dysfunction in patients with rheumatoid arthritis (RA) with metabolic changes. We examined 158 patients with RA (91,8 % – women and 8,2 % – men) aged 21 to 80 years old with the average duration of diseases – 9 [4–15] years. Negative correlations of average strength between the indices of the estimated glomerular filtration rate (eGFR) according to the 2009 CKD-EPI formula and the level of ANGPTL 3 (r = –0,32, p < 0,001) and ANGPTL 4 (rS = –0,31, p < 0,001) were revealed. It was found that renal dysfunction and the presence of metabolic syndrome (R 2 = 0,33) are the two factors which have a direct effect on the ANGPTL 4 concentration in RA patients’ serum. ANGPTL type 4 should be considered as a key factor linking the development of renal dysfunction and metabolic changes caused by rheumatoid inflammation

scholarly journals Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature

2019 ◽  
Vol 48 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Elena Colombino ◽  
Ilaria Biasato ◽  
Elena Biasibetti ◽  
Alessandra Sereno ◽  
Laura Chiappino ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Veterinary Medicine ◽  
Potential Role ◽  
Review Of The Literature
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