scholarly journals Technical Appendix: Non-Group and Uninsured Population Database

2020 ◽  
Author(s):  
Keyword(s):  
Population Database ◽  
Uninsured Population

scholarly journals Two Approaches for a Genetic Analysis of Pompe Disease: A Literature Review of Patients with Pompe Disease and Analysis Based on Genomic Data from the General Population

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 601
Author(s):  
Kyung-Sun Park
Keyword(s):  
General Population ◽  
Pompe Disease ◽  
Genomic Data ◽  
Japanese Patients ◽  
Population Database ◽  
Genome Database ◽  
Genetic Database ◽  
Pathogenic Variants ◽  
Reference Genome Database ◽  
Real Patients

In this study, two different approaches were applied in the analysis of the GAA gene. One was analyzed based on patients with Pompe disease, and the other was analyzed based on GAA genomic data from unaffected carriers in a general population genetic database. For this, GAA variants in Korean and Japanese patients reported in previous studies and in patients reported in the Pompe disease GAA variant database were analyzed as a model. In addition, GAA variants in the Korean Reference Genome Database (KRGDB), the Japanese Multi Omics Reference Panel (jMorp), and the Genome Aggregation Database (gnomAD) were analyzed. Overall, approximately 50% of the pathogenic or likely pathogenic variants (PLPVs) found in unaffected carriers were also found in real patients with Pompe disease (Koreans, 57.1%; Japanese, 46.2%). In addition, there was a moderate positive correlation (Spearman’s correlation coefficient of 0.45–0.69) between the proportion of certain PLPVs in patients and the minor allele frequency of their variants in a general population database. Based on the analysis of general population databases, the total carrier frequency for Pompe disease in Koreans and Japanese was estimated to be 1.7% and 0.7%, respectively, and the predicted genetic prevalence was 1:13,657 and 1:78,013, respectively.

scholarly journals Clinical validity of a population database definition of remission in patients with major depression

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Antoni Sicras-Mainar ◽  
Milagrosa Blanca-Tamayo ◽  
Laura Gutiérrez-Nicuesa ◽  
Jordi Salvatella-Pasant ◽  
Ruth Navarro-Artieda
Keyword(s):  
Major Depression ◽  
Clinical Validity ◽  
Population Database ◽  
Definition Of

Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database

2006 ◽  
Vol 152 (2) ◽  
pp. 305-311 ◽  
Author(s):  
Benjamin D. Horne ◽  
Nicola J. Camp ◽  
Joseph B. Muhlestein ◽  
Lisa A. Cannon-Albright
Keyword(s):  
Heart Diseases ◽  
Population Database ◽  
Coronary Heart Diseases ◽  
Extended Pedigrees

scholarly journals EPID-11. THE CONTRIBUTION OF THE rs55705857 G ALLELE TO FAMILIAL CANCER RISK USING THE UTAH POPULATION DATABASE

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi57-vi57
Author(s):  
Sarah Hummel ◽  
Wendy Kohlmann ◽  
Thomas Kollmeyer ◽  
Robert Jenkins ◽  
Joshua Sonnen ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Familial Cancer ◽  
Population Database ◽  
Familial Cancer Risk

scholarly journals S67 Mortality in copd patients following community acquired pneumonia: a population database analysis of linked healthcare records

Thorax ◽  
2016 ◽  
Vol 71 (Suppl 3) ◽  
pp. A40.1-A40
Author(s):  
N Williams ◽  
NA Coombs ◽  
M Johnson ◽  
L Josephs ◽  
LA Rigge ◽  
...  
Keyword(s):  
Community Acquired Pneumonia ◽  
Database Analysis ◽  
Population Database ◽  
Copd Patients

Forensic genetic data of 6 Y-STR loci: An expanded Korean population database

2012 ◽  
Vol 6 (1) ◽  
pp. e35-e36 ◽  
Author(s):  
Soon Hee Kim ◽  
Seung Beom Hong ◽  
Kyoung Don Kwak ◽  
Eun Jung Lee ◽  
Jong Jin Kim ◽  
...  
Keyword(s):  
Genetic Data ◽  
Korean Population ◽  
Population Database ◽  
Str Loci ◽  
Forensic Genetic

Patterns of use and trends in the use of medications for the control of COPD in a cohort of Colombian patients, 2017-2019 v1

2021 ◽  
Author(s):  
Jorge Machado Alba
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Inhaled Corticosteroids ◽  
Chronic Obstructive ◽  
Population Database ◽  
Obstructive Pulmonary Disease ◽  
Prescription Patterns ◽  
Short Acting ◽  
Patterns Of Use ◽  
Long Acting

Introduction: Chronic obstructive pulmonary disease (COPD) affects approximately 174 million people worldwide.The objective was to determine the trends of the use of medications for COPD in a group of Colombian patients. Methods: This was a retrospective study on prescription patterns of bronchodilators and other medications used in COPD from a population database with follow-up at 12 and 24 months. Patients older than 18 years of age of any sex who had COPD between 2017 and 2019 were included. Sociodemographic variables, medications, treatment schedules for COPD, comorbidities, comedications, and the specialty of the prescriber were considered. Results: A total of 9,476 people with a diagnosis of COPD were evaluated. They had a mean age of 75.9 ± 10.7 years, 50.1% were men, and 86.8% were prescribed by a general practitioner. At the beginning of the follow-up, on average, they received 1.6 medications/patient, mainly short-acting antimuscarinics (3784; 39.9%), followed by short-acting β-agonists (2997, 31.6%) and inhaled corticosteroids (ICS) (2239, 23.6%), but 5083 (53.6%) patients received a long-acting bronchodilator. At the beginning of the follow-up, 645 (6.8%) patients were put on triple therapy with antimuscarinics, β-agonists, and ICS, and at 12 months, this rose to 1388 (20.6%). A total of 57.9% had comorbidities, most often hypertension (44.4%). Conclusions: This group of patients with COPD treated in Colombia frequently received short-acting bronchodilators and ICS, but a growing proportion are undergoing controlled therapy with long-acting bronchodilators, a situation that can improve the indicators of morbidity, exacerbations, and hospitalization.

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